Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Siberian Cocklebur Non-Alcohol Ingredients & Drug Interactions

by Hawaii Pharm

Siberian Cocklebur Non-Alcohol label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Siberian Cocklebur Non-Alcohol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Siberian Cocklebur Non-Alcohol is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for nasal congestion and sinus problems, allergic rhinitis (hay fever), headache.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Siberian Cocklebur Fruit Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Siberian Cocklebur Non-Alcohol by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Siberian Cocklebur Non-Alcohol by Hawaii Pharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Siberian Cocklebur Non-Alcohol by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Siberian Cocklebur Fruit Extract in dry form. The liquid also holds glycerin and water as inactive ingredients to deliver it.

Siberian cocklebur is a plant extract that's been used traditionally, but it comes with serious safety concerns. The fruit itself contains toxic compounds and has caused poisoning in people who consumed it.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Siberian Cocklebur product and its label doesn't state a use — see Siberian Cocklebur's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness ratings for Siberian cocklebur in our data, so we can't tell you what it's meant to help with or how well it works. That said, the safety profile is severe enough that any potential benefit may not be worth the risk.

The evidence, ingredient by ingredient Siberian Cocklebur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Siberian cocklebur is generally regarded as unsafe for use. The fruit can cause serious poisoning and has triggered a range of harmful effects: abdominal pain, nausea, vomiting, severe low blood sugar, liver damage (elevated liver enzymes), increased bleeding risk, dizziness, trouble breathing, fever, and heart problems.

Within hours to a few hours after taking it, palpitations and abnormal heart rhythms can start. In severe cases, people have developed metabolic acidosis (dangerously acidic blood) and required hospitalization; some deaths have occurred.

Do not use this product during pregnancy or while breastfeeding. The safety data advises against it because of potential toxicity and lack of reliable safety evidence.

Side effects, ingredient by ingredient Siberian Cocklebur

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Siberian Cocklebur.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 663 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Do not take this product if you take antidiabetes drugs (insulin, glimepiride, glyburide, and others), hepatotoxic drugs (liver-damaging medications), or nephrotoxic drugs (kidney-damaging medications). All three categories carry Major interaction severity.

Check your medications with the tool on this page before even considering this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

We can't recommend this product. The safety concerns and Major interactions with blood sugar, liver, and kidney medications are too serious.

If you're considering it for a specific condition, talk with your pharmacist or doctor first—there are likely safer alternatives.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Siberian Cocklebur Non-Alcohol, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253649126
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332074
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Siberian Cocklebur Non-Alcohol by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253649126
IngredientAmount% DV
Siberian Cocklebur Fruit Extract, Dry1156 mg--

Other ingredients: Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications. Keep out of the reach of children!

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR code to get more info or reorder

Formula

Xanthium strumarium

Formulation

Only natural ingredients Identity and purity is laboratory verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives C2H5OH Alcohol free

Made in USA, Hawaii

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Siberian Cocklebur Non-Alcohol by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Siberian Cocklebur Non-Alcohol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Siberian Cocklebur Non-Alcohol by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Siberian Cocklebur Fruit Extract, Dry

Interacts with
662 drugs
1156 mg per serving

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. H...

Siberian Cocklebur Fruit Extract, Dry monograph & interactions

Other (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Siberian Cocklebur Non-Alcohol by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Siberian Cocklebur Non-Alcohol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
662Drugs
662 Major

Ingredients driving the most interactions

Siberian Cocklebur Fruit Extract, Dry 662

Individual Drug Interactions

The ingredients in Siberian Cocklebur Non-Alcohol interact with 662 drugs. Click any drug to see the details.

1 of the 1 ingredient in Siberian Cocklebur Non-Alcohol interact with drugs. Each result below shows which ingredient is responsible. Siberian Cocklebur Fruit Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Siberian Cocklebur Non-Alcohol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Siberian Cocklebur Fruit Extract, Dry3 drug types · 662 drugs

Antidiabetes Drugs

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans. Hypoglycemia occurs soon after consumption and worsens with time in most cases. Do not use Siberian cocklebur in people taking medications that also lower blood glucose.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Likely Evidence B
Hepatotoxic Drugs

Siberian cocklebur can adversely affect the liver. It has been linked to many cases of hepatotoxicity and some cases of liver failure. Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo).

Likelihood Likely Evidence B
Nephrotoxic Drugs

Siberian cocklebur can adversely affect the kidney. Theoretically, combining Siberian cocklebur with potentially nephrotoxic drugs might have additive harmful effects on kidney function.
Some potentially nephrotoxic drugs include cyclosporine (Neoral, Sandimmune); aminoglycosides including amikacin (Amikin), gentamicin (Garamycin, Gentak, others), and tobramycin (Nebcin, others); nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, Nuprin, others), indomethacin (Indocin), naproxen (Aleve, Anaprox, Naprelan, Naprosyn), piroxicam (Feldene); and numerous others.

Likelihood Likely Evidence B
Siberian Cocklebur Fruit Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Siberian Cocklebur Non-Alcohol, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St STE 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-542-9244
Web Address
Hawaiipharm.com
Pharmacist Counseling Corner

Siberian Cocklebur Non-Alcohol by Hawaii Pharm: Common Questions

Does Siberian Cocklebur Non-Alcohol by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Siberian Cocklebur Non-Alcohol has a known interaction with 662 medications, including 662 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Siberian Cocklebur Non-Alcohol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Siberian cocklebur used for?
We don't have effectiveness data on file for this ingredient, so we can't tell you what condition it's meant to treat or whether it works.
Is it safe to take while I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy and while breastfeeding because of potential toxicity and lack of safety evidence.
What are the side effects?
Siberian cocklebur can cause abdominal pain, nausea, vomiting, severe low blood sugar, liver damage, increased bleeding, dizziness, trouble breathing, fever, and heart problems including palpitations and irregular heartbeat. These can start within hours of taking it.
Why is there a warning about liver and kidney damage?
Siberian cocklebur itself can harm your liver and kidneys. If you take it with drugs that also damage those organs, the damage could be worse—that's why those are Major interactions.
Can I take this if I'm on blood sugar medication?
No. Siberian cocklebur causes severe low blood sugar on its own, and combining it with diabetes medications could trigger a dangerous drop. This is a Major interaction.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Siberian Cocklebur Non-Alcohol is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Siberian Cocklebur Non-Alcohol label
Go deeper

The Full Monographs Behind Siberian Cocklebur Non-Alcohol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Siberian Cocklebur

Interacts with 662 drugs

Siberian cocklebur is a fruit used in traditional Chinese and other Asian herbal medicine, mainly for nasal congestion, sinus issues, and allergies. Human evidence is very limited, and the p...

Read the full Siberian Cocklebur monograph →
Sources

Sources & How We Checked

Siberian Cocklebur Non-Alcohol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Siberian Cocklebur 4 references
  1. Wu, M. L., Wang, C. P., and Deng, J. F. Fatal hepatic failure due to fructus xanthii in a child. Abstracts of the 2005 North American Congress of Clinical Toxicology Annual Meeting. Clin Toxicol 2005;43:639. DOI
  2. Gurley ES, Rahman M, Hossain MJ, et al. Fatal outbreak from consuming Xanthium strumarium seedlings during time of food scarcity in northeastern Bangladesh. PLoS One 2010 Mar 18;5(3):e9756. PubMed
  3. Turgut M, Alhan CC, Gurgoze M, et al. Carboxyatractyloside poisoning in humans. Ann Trop Paediatr 2005;25(2):125-34. PubMed
  4. Karabiber H, Almis H, Selimoglu MA, Yakinci C, Yilmaz S. Xanthium strumarium poisoning requiring liver transplantation. J Pediatr Gastroenterol Nutr. 2014;58(1):e6-9.

See these in context on the Siberian Cocklebur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team