Xian Ling Pi Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Xian Ling Pi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Xian Ling Pi is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Xian Ling Pi Herb Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Xian Ling Pi by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Xian Ling Pi by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Xian Ling Pi by Hawaii Pharm
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — Horny Goat Weed.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
- For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Xian Ling Pi, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 184025360 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | Off market |
| Date entered into DSLD | May 24, 2023 |
| DSLD ID | 293171 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Xian Ling Pi by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Xian Ling Pi Herb Extract, Dry | 983 mg | -- |
Other ingredients: Ethyl Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2015
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water, up to 4 times per day.
Storage
Store in a cool dry place.
Precautions
Caution: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. Do not use if seal is broken or missing. May have contraindications. Can cause side effects and adverse reactions.
Keep out of reach of children.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
For reorder simply scan this QR-code or visit: www.hawaiipharm.com
Formula
(Epimedium brevicornum)
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature Doesn't contain artificial colors, flavors, or preservatives
Not tested on animals
Made in USA, Hawaii in an FDA registered facility.
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
USA Made in United States of America
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Xian Ling Pi by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Xian Ling Pi by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Xian Ling Pi Herb Extract, Dry
Interacts with963 drugs
Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...
Xian Ling Pi Herb Extract, Dry monograph & interactionsOther (inactive) ingredients: Ethyl Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Xian Ling Pi by Hawaii Pharm Drug Interactions
Xian Ling Pi contains a single active ingredient, and it has known interactions with 963 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Xian Ling Pi?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Xian Ling Pi interact with 963 drugs. Click any drug to see the details.
1 of the 1 ingredient in Xian Ling Pi interact with drugs. Each result below shows which ingredient is responsible. Xian Ling Pi Herb Extract, Dry
Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
How Aspirin, Caffeine, Dover's Pwd interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
How Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interactionAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
How Aspirin, Caffeine, Orphenadrine interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 2b6 (cyp2b6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
How Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interactionAspirin, CarisoprodolSoma Compound
How Aspirin, Carisoprodol interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
How Aspirin, Citric Acid, Sodium Bicarbonate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 2b6 (cyp2b6) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
How Aspirin, Dipyridamole interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Xian Ling Pi — through 1 ingredient. Tap an ingredient for the detail:
Xian Ling Pi Herb Extract, DryCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Xian Ling Pi Herb Extract, Dry + Aspirin, Pentazocine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Xian Ling Pi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Xian Ling Pi Herb Extract, Dry
Anticoagulant/Antiplatelet Drugs
Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.
Antihypertensive Drugs
Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.
Brand information
Manufacturer and brand details for Xian Ling Pi, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 1-808-385-6076
- Web Address
- www.hawaiipharm.com
Xian Ling Pi by Hawaii Pharm: Common Questions
Does Xian Ling Pi by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Xian Ling Pi is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Xian Ling Pi’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Xian Ling Pi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Horny Goat Weed 11 references
- Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
- Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
- De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
- Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
- Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
- Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
- Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
- Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
- Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
- Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC