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Dietary supplement

Yi Yi Ren Ingredients & Drug Interactions

by Hawaii Pharm

Yi Yi Ren label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yi Yi Ren against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Yi Yi Ren is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for digestive support, skin health and smoothness, mild swelling or water retention.Based on those ingredients, 128 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coix lacryma-jobi Seed Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Yi Yi Ren by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Yi Yi Ren by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Yi Yi Ren by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Yi Yi Ren is a liquid extract containing one active ingredient: Coix lacryma-jobi seed extract, commonly called Job's tears. It also contains alcohol, water, and glycerin as inactive ingredients to preserve and deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Job's Tears product and its label doesn't state a use — see Job's Tears's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Job's tears in treating high cholesterol (hyperlipidemia) is not established in the data we hold. We list insufficient reliable evidence to rate its usefulness for this purpose.

If you're considering it for cholesterol, talk with your pharmacist or doctor about what the current research actually shows.

The evidence, ingredient by ingredient Job's Tears

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Job's tears is generally well tolerated when used as a cooked food, though concentrated supplement evidence is limited. The safety data we hold advise against use in pregnancy, and there isn't enough reliable data on lactation.

If you're pregnant, breastfeeding, or planning to be, talk with your doctor or pharmacist before using this product. No adverse effects are documented in the data we hold, but this doesn't mean none can occur—especially since concentrated supplement evidence is limited compared to the cooked food form.

Side effects, ingredient by ingredient Job's Tears

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Job's Tears.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 128 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Yi Yi Ren, double-check with your pharmacist if you take antidiabetes drugs (insulin, glimepiride, glyburide, pioglitazone, rosiglitazone), theophylline, dextromethorphan cough suppressants, the muscle relaxer chlorzoxazone, or diltiazem heart medication. All carry Moderate-severity interactions with Job's tears extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Yi Yi Ren might appeal to someone interested in Job's tears as a supplement, but if you take diabetes medications, heart drugs, or a cough suppressant, you'll need to check with your pharmacist first. Anyone pregnant or breastfeeding should talk with their doctor before starting.

The biggest step is running your actual medications through the checker on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yi Yi Ren, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253658333
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 302008
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yi Yi Ren by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253658333
IngredientAmount% DV
Coix lacryma-jobi Seed Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Coix lacryma-jobi

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yi Yi Ren by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yi Yi Ren label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yi Yi Ren by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Coix lacryma-jobi Seed Extract, Dry

Interacts with
128 drugs
983 mg per serving

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is...

Coix lacryma-jobi Seed Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yi Yi Ren by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Yi Yi Ren?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
128Drugs
128 Moderate

Ingredients driving the most interactions

Coix lacryma-jobi Seed Extract, Dry 128

Individual Drug Interactions

The ingredients in Yi Yi Ren interact with 128 drugs. Click any drug to see the details.

1 of the 1 ingredient in Yi Yi Ren interact with drugs. Each result below shows which ingredient is responsible. Coix lacryma-jobi Seed Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Yi Yi Ren with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coix lacryma-jobi Seed Extract, Dry5 drug types · 128 drugs

Antidiabetes Drugs

Preliminary evidence shows that constituents of Job's tears might have hypoglycemic effects. Theoretically, concomitant use with drugs that decrease blood glucose levels might increase the risk of hypoglycemia. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Chlorzoxazone (Parafon Forte, Paraflex)

Animal research suggests that Job's tears might enhance absorption of chlorzoxazone in the small intestine. Single dose and short-term oral administration of Job's tears bran ethanolic extract along with oral administration of a five-drug cocktail containing chlorzoxazone increases chlorzoxazone peak plasma concentration and area under the plasma concentration-time curve (AUC) without altering major cytochrome P450 activities in the liver. This effect has not been reported in humans.

Likelihood Possible Evidence D
Dextromethorphan (Robitussin Dm, Others)

Animal research suggests that Job's tears might enhance absorption of dextromethorphan in the small intestine. Single dose oral administration of Job's tears bran ethanolic extract along with oral administration of a five-drug cocktail containing dextromethorphan increases dextromethorphan area under the plasma concentration-time curve (AUC) without altering major cytochrome P450 activities in the liver. This effect has not been reported in humans.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Animal research suggests that Job's tears might enhance absorption of diltiazem in the small intestine. Single dose oral administration of Job's tears bran ethanolic extract along with oral administration of a five-drug cocktail containing diltiazem increases diltiazem peak plasma concentration and area under the plasma concentration-time curve (AUC) without altering major cytochrome P450 activities in the liver. This effect has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Animal research suggests that Job's tears might enhance absorption of theophylline in the small intestine. Single dose and short-term oral administration of Job's tears bran ethanolic extract along with oral administration of a five-drug cocktail containing theophylline increases theophylline peak plasma concentration and area under the plasma concentration-time curve (AUC) without altering major cytochrome P450 activities in the liver. This effect has not been reported in humans.

Likelihood Possible Evidence D
Coix lacryma-jobi Seed Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yi Yi Ren, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Yi Yi Ren by Hawaii Pharm: Common Questions

Does Yi Yi Ren by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Yi Yi Ren has a known interaction with 128 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yi Yi Ren contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Job's tears, and why is it in this product?
Job's tears is the seed from Coix lacryma-jobi, a plant used traditionally in supplements. Hawaii Pharm has made it into a liquid extract, which is the single active ingredient in Yi Yi Ren.
Can I take this if I'm pregnant?
The safety data advise against using Job's tears in pregnancy, and human data are lacking. If you're pregnant or planning to be, talk with your doctor or pharmacist before starting.
Can I take this while breastfeeding?
There isn't enough reliable data to know whether Job's tears is safe during breastfeeding. Check with your doctor or pharmacist for personalized advice.
What are the side effects I should watch for?
No adverse effects are documented in the data we hold. That said, concentrated supplement evidence is limited compared to using Job's tears as a cooked food, so stay alert for any unexpected changes and report them to your pharmacist.
Does this actually help with high cholesterol?
We don't have enough reliable evidence to rate whether Job's tears works for high cholesterol. If that's why you're interested, talk with your doctor about treatments with established evidence first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Yi Yi Ren is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yi Yi Ren label
Go deeper

The Full Monographs Behind Yi Yi Ren’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Job's Tears

Interacts with 128 drugs

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is being studied for possible effects on m...

Read the full Job's Tears monograph →
Sources

Sources & How We Checked

Yi Yi Ren's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Job's Tears 3 references
  1. Chiang W, Cheng C, Chiang M, Chung KT. Effects of dehulled adlay on the culture count of some microbiota and their metabolism in the gastrointestinal tract of rats. J Agric Food Chem 2000;48:829-32. PubMed
  2. Yu YM, Chang WC, Liu CS, Tsai CM. Effect of young barley leaf extract and adlay on plasma lipids and LDL oxidation in hyperlipidemic smokers. Biol Pharm Bull 2004;27:802-5. PubMed
  3. Yao HT, Lin JH, Liu YT, Li ML, Chiang W. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients 2019;11(10):2473. PubMed

See these in context on the Job's Tears monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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