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Dietary supplement

Youth Restorer Ingredients & Drug Interactions

by New Sun

Youth Restorer label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Youth Restorer against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Youth Restorer is a dietary supplement by New Sun with 8 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 1,117 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cat's Claw, L-Arginine, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Youth Restorer by New Sun

Ask about any prescription or over-the-counter medication and we check it for interactions with Youth Restorer by New Sun — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Youth Restorer by New Sun

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (5,673 mg) without saying how much of each component you get.

Youth Restorer contains eight active ingredients: L-Glutamine, L-Arginine, L-Tyrosine, L-Proline, L-Glycine, L-Ornithine, L-Lysine, and Cat's Claw. These are all amino acids or herbal extracts meant to support various body functions.

The product also contains inactive ingredients — citric acid, rice concentrate, silicon dioxide, natural lemon and orange flavoring, and stevia extract — which serve as fillers, flavor, and sweetener.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: restore youthful feeling and appearance.
  • We looked for evidence on: Aging, Athletic performance, Cognitive function, Exercise-induced muscle damage, Fatigue, Insomnia — and 4 related terms.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function, Memory.

The evidence for these ingredients is mixed. L-Glutamine is Effective for sickle cell disease and Possibly Effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

L-Tyrosine is Effective for phenylketonuria (PKU) and Possibly Effective for cognitive function and memory, though it was Possibly Ineffective for athletic performance. L-Lysine is Possibly Effective for cold sores (herpes labialis).

L-Ornithine is Possibly Effective for athletic performance. L-Proline, L-Glycine (except Possibly Effective for schizophrenia), and Cat's Claw all have Insufficient Reliable Evidence for their claimed uses in our data.

The evidence, ingredient by ingredient Glutamine L-arginine Tyrosine Proline Glycine Ornithine Lysine Cat's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at typical doses. L-Glutamine, L-Arginine, L-Tyrosine, and L-Lysine can cause mild gastrointestinal side effects — bloating, nausea, diarrhea, abdominal pain — especially at higher doses.

L-Arginine can lower blood pressure, which may not be safe for everyone, and L-Tyrosine safety for self-treatment isn't well established. Cat's Claw has case reports of kidney injury, though causation is unclear, and generally well-tolerated short-term safety data are limited for long-term use.

Pregnancy and breastfeeding data are limited: L-Glutamine is Likely Safe in pregnancy and lactation; L-Tyrosine, L-Proline, L-Glycine, and L-Lysine have insufficient data (talk to your doctor); L-Arginine has no pregnancy/lactation rating on file; L-Ornithine and Cat's Claw should be avoided in pregnancy and lactation due to lack of safety data.

Side effects, ingredient by ingredient Glutamine L-arginine Tyrosine Proline Glycine Ornithine Lysine Cat's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 8 matched ingredients can interact with medications — Lysine, Cat's Claw, L-arginine, Glutamine, Tyrosine, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,118 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take blood pressure medications (antihypertensives, ACE inhibitors, ARBs, or calcium channel blockers), anticoagulants or antiplatelet drugs (blood thinners), seizure medications (anticonvulsants), levodopa (Parkinson's disease), thyroid hormones, clozapine (antipsychotic), medications metabolized by CYP3A4 (a large group including many statins and some antihistamines), immunosuppressants, or Paxlovid. These are the medication types documented to interact with ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Youth Restorer is a multi-ingredient amino acid and herbal powder best suited for people without active medical conditions or those taking no medications. If you take any prescription drug — especially blood pressure medication, seizure drugs, blood thinners, thyroid medication, Parkinson's medication, clozapine, or Paxlovid — check with your pharmacist before using this product.

Pregnant or breastfeeding? Talk to your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Youth Restorer, straight from the product label.

Brand New Sun
Barcode (UPC) 91-5
Net contents 16 oz.; 454 Gram(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203558
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Youth Restorer by New Sun, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.5 Gram(s)
Maximum serving Sizes:
7.5 Gram(s)
Servings per container
61
UPC/BARCODE
91-5
IngredientAmount% DV
L-Glutamine0 NP--
L-Arginine0 NP--
L-Tyrosine0 NP--
L-Proline0 NP--
Proprietary Blend5673 mg--
L-Glycine0 NP--
L-Ornithine0 NP--
L-Lysine0 NP--
Cat's Claw0 NP--

Other ingredients: Citric Acid, Rice concentrate, Silicon Dioxide, natural Lemon flavoring, natural Orange flavoring, Stevia extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommendation: As a dietary supplement, take two times a day between meals on an empty stomach in the morning and afternoon. Mix one scoop in cup of water (tastes great). May also be taken at bedtime to support normal sleep patterns.

Formulation

Maxium HGH is completely sugar free, formulated for all ages. Especially for ages 40 and up.

Maximum HGH contains no actual growth hormones but amino acids for the purpose of encouraging the production of your body's natural human growth hormone (HGH).

Sugar free

Precautions

Do not use if safety seal is missing or broken.

Keep out of reach of children.

Warning: If you are pregnant, nursing, taking any medications, or experiencing any health issues, consult your doctor before use. Using amino acids above recommended levels or without consulting with a medical provider may lead to future problems.

Storage

Store in a cool, dry place.

General Statements

This special blend of amino acids could help restore a more youthful feeling and appearance.

Promotes tighter, sleeker, smoother skin Supports normal sleep patterns Promotes more sculptured body with exercise Supports the feeling of well-being Stimulates mental and physical energy Helps maintain physical performance Supports menstrual cycle regulation Supports endurance and stamia Supports normal heart, kidney, and liver functions Improves stress handling Suppresses appetite Supports immune system Improves absentmindedness Promotes youthful feeling Promotes reduced hot flashes Promotes strong bones

Promotes youthful feelings Tastes great

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

Product 91-5 v6.0

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Youth Restorer by New Sun label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Youth Restorer label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Youth Restorer by New Sun

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.5 Gram(s) Dosage formPowder Servings per container61 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

5673 mg per serving

Other (inactive) ingredients: Citric Acid, Rice concentrate, Silicon Dioxide, Natural Lemon flavoring, Natural Orange flavoring, Stevia extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Youth Restorer by New Sun Drug Interactions

Want to check YOUR meds against Youth Restorer?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,117Drugs
1,113 Moderate 4 Minor

Ingredients driving the most interactions

Cat's Claw 962
L-Arginine 403
L-Glutamine 50
L-Tyrosine 21
L-Glycine 1

Individual Drug Interactions

The ingredients in Youth Restorer interact with 1,117 drugs. Click any drug to see the details.

6 of the 8 ingredients in Youth Restorer interact with drugs. Each result below shows which ingredient is responsible. Cat's Claw L-Arginine L-Glutamine L-Tyrosine L-Glycine L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Youth Restorer with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cat's Claw6 drug types · 962 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Calcium Channel Blockers

Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.

Likelihood Possible Evidence D
Nirmatrelvir/Ritonavir (Paxlovid)

Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cat's Claw full monograph & interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D
L-Tyrosine full monograph & interactions

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
L-Glycine full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Youth Restorer, from the product label.

New Sun

See all New Sun products
Name
New Sun, Inc.
City
Hendersonville
State
NC
ZipCode
28792
Phone Number
(800) 544-0777
Web Address
mynewsun.com
Pharmacist Counseling Corner

Youth Restorer by New Sun: Common Questions

Does Youth Restorer by New Sun interact with any medications?
Yes. Based on its ingredients, Youth Restorer has a known interaction with 1,117 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Youth Restorer contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Youth Restorer if I'm pregnant?
L-Glutamine is Likely Safe in pregnancy. The other active ingredients — L-Arginine, L-Tyrosine, L-Proline, L-Glycine, and L-Lysine — don't have enough safety data; L-Ornithine and Cat's Claw should be avoided. Talk to your doctor or pharmacist about whether this product is right for you during pregnancy.
What side effects might I experience?
The most common side effects are mild gastrointestinal — bloating, nausea, diarrhea, abdominal pain, and heartburn. L-Arginine can lower blood pressure. Most people tolerate these ingredients at typical doses, but effects vary.
Is Youth Restorer supposed to improve my athletic performance?
L-Ornithine is Possibly Effective for athletic performance, but L-Tyrosine was Possibly Ineffective for it in our data. The evidence for the other ingredients in this product supporting athletic performance isn't established.
What is Cat's Claw and why is it in this product?
Cat's Claw is a plant extract used traditionally in herbal medicine. In our data, we don't have reliable evidence that it's effective for any of the conditions often claimed. It does interact with several medications, so it's important to check before use.
What are the inactive ingredients, and does this powder contain fillers?
Yes, it contains inactive ingredients: citric acid, rice concentrate, silicon dioxide, natural lemon and orange flavoring, and stevia extract. These serve as fillers, flavor, and sweetener — that's normal for powdered supplements.
Will this product work for wound healing or bone health?
L-Proline is often used in collagen supplements for these purposes, but we don't have reliable evidence it works for wound healing, osteoporosis, fractures, or osteopenia. The other ingredients in this product aren't established for bone or wound support either.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Youth Restorer label
Go deeper

The Full Monographs Behind Youth Restorer’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Tyrosine

Interacts with 21 drugs

L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...

Read the full Tyrosine monograph → Herb & supplement monograph

Proline

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...

Read the full Proline monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Cat's Claw

Interacts with 962 drugs

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...

Read the full Cat's Claw monograph →
Sources

Sources & How We Checked

Youth Restorer's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 114 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
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