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Dietary supplement

ZBiotics Pre-Alcohol Probiotic Drink Ingredients & Drug Interactions

by ZBiotics

ZBiotics Pre-Alcohol Probiotic Drink label
See full label image
Liquid Category: Probiotic Supplement Drink
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Aug 30, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking ZBiotics Pre-Alcohol Probiotic Drink against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ZBiotics Pre-Alcohol Probiotic Drink is a dietary supplement by ZBiotics with 1 active ingredient. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus subtilis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Bacillus subtilis, a live probiotic bacterium. The drink also includes organic coconut water complex, natural flavors, potassium sorbate (a preservative), and sodium chloride (salt) as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: acetaldehyde breakdown after alcohol consumption.
  • We looked for evidence on: hangover, alcohol-related nausea, next-day alcohol effects.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Bacillus subtilis is possibly effective for antibiotic-associated diarrhea — the kind you might get after taking antibiotics. For athletic performance, cirrhosis, constipation, eczema, and diabetes, the evidence we hold isn't established yet, so we can't rate how well it works for those uses.

The evidence, ingredient by ingredient Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus subtilis is generally well tolerated in healthy adults, though quality and safety can vary depending on the product and strain. One trial participant reported headache, and diarrhea has been reported rarely.

There's limited safety data overall, so talk with your doctor before starting it. Some case reports describe serious infections (bacteremia and meningitis) linked to consumption of natto, a fermented soybean product containing Bacillus subtilis var. natto, particularly in people with weakened immune systems or serious underlying illnesses.

This is a rare event, but if you have a compromised immune system, mention this product to your doctor first.

Side effects, ingredient by ingredient Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on antibiotic drugs, double-check the timing with your doctor or pharmacist before taking this product — antibiotics can reduce how well this probiotic works, so you'll want to space them out. Altogether, these interactions span 182 individual medications, so confirm your specific antibiotics on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help if you're dealing with antibiotic-associated diarrhea. If you're currently taking antibiotics, separate the timing of the two — check with your doctor or pharmacist about when to take each one.

If you have a weakened immune system or serious health conditions, talk it over with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 30, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ZBiotics Pre-Alcohol Probiotic Drink, straight from the product label.

Brand ZBiotics
Barcode (UPC) 860001276817
Net contents 12 Bottles (15 mL / 0.5 fl oz each; 6 Fluid Ounces total)
Market status On market
Added to our catalog Aug 30, 2026
Product type Probiotic Supplement Drink
Supplement form Liquid
Dietary claims / uses Breaks down acetaldehyde produced when drinking alcohol, Feel better the day after drinking, Set yourself up for a great next morning
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
1 Bottle (15 mL / 0.5 fl oz)
Maximum serving Sizes:
1 Bottle (15 mL / 0.5 fl oz)
Servings per container
12
UPC/BARCODE
860001276817
IngredientAmount% DV
Bacillus subtilis----

Other ingredients: organic Coconut Water Complex, Natural Flavors, Potassium Sorbate, Sodium Chloride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested Use

DRINK BEFORE DRINKING: 1) Drink Pre-Alcohol. 2) Drink Responsibly. 3) Enjoy tomorrow.

For the best results, make Pre-Alcohol your first drink of the night.

Storage

Shake before use. No need to refrigerate.

Marketing

Drink Responsibly, for an Easier Tomorrow

Feel better the day after drinking with ZBiotics Probiotic Drink

Using genetic engineering, our team of PhD microbiologists built a probiotic that breaks down acetaldehyde.

Pre-Alcohol helps the gut process acetaldehyde by adding a probiotic, Bacillus subtilis ZB183, which produces the same enzyme the liver uses to break it down.

Other

RESPONSIBLE USE: Drink responsibly. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

ZBiotics Pre-Alcohol Probiotic Drink label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Bottle (15 mL / 0.5 fl oz) Dosage formLiquid Servings per container12 Amounts shown are per serving.

Bacillus subtilis

Interacts with
182 drugs
Form: genetically engineered probiotic strain in liquid drink

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

Bacillus subtilis monograph & interactions

Other (inactive) ingredients: Organic Coconut Water Complex, Natural Flavors, Potassium Sorbate, Sodium Chloride. These complete the product’s ingredient list but are not active constituents.

Interaction report

ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics Drug Interactions

Want to check YOUR meds against ZBiotics Pre-Alcohol Probiotic Drink?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus subtilis 182

Individual Drug Interactions

The ingredients in ZBiotics Pre-Alcohol Probiotic Drink interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in ZBiotics Pre-Alcohol Probiotic Drink interact with drugs. Each result below shows which ingredient is responsible. Bacillus subtilis

Each ingredient & the kinds of drugs it affects

For each ingredient in ZBiotics Pre-Alcohol Probiotic Drink with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus subtilis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ZBiotics Pre-Alcohol Probiotic Drink, from the product label.

ZBiotics

See all ZBiotics products
Pharmacist Counseling Corner

ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics: Common Questions

Does ZBiotics Pre-Alcohol Probiotic Drink by ZBiotics interact with any medications?
Yes. Based on its ingredients, ZBiotics Pre-Alcohol Probiotic Drink has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ZBiotics Pre-Alcohol Probiotic Drink contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with diarrhea from antibiotics?
Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. If that's what you're dealing with, this could be worth trying — but talk with your doctor or pharmacist first, especially about timing it separately from your antibiotics.
Can I take this while I'm on antibiotics?
You can, but you'll need to separate them. Antibiotics can kill the live organisms in this drink and make it less effective. Ask your doctor or pharmacist how far apart to space them.
What are the side effects?
Bacillus subtilis is generally well tolerated. One trial participant reported headache, and diarrhea has been reported rarely. Serious infections are extremely rare but have been reported in people with very weakened immune systems.
Is it safe in pregnancy or while breastfeeding?
We don't have safety data for Bacillus subtilis during pregnancy or lactation. Talk with your doctor before taking it if you're pregnant or breastfeeding.
Does it work for athletic performance or digestive health in general?
For athletic performance and general constipation, the evidence isn't established in our data. For antibiotic-associated diarrhea specifically, it's possibly effective.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ZBiotics Pre-Alcohol Probiotic Drink is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ZBiotics Pre-Alcohol Probiotic Drink label
Go deeper

The Full Monographs Behind ZBiotics Pre-Alcohol Probiotic Drink’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

ZBiotics Pre-Alcohol Probiotic Drink's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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