Inactive ingredients by manufacturer

Leucovorin inactive ingredients by manufacturer

Wondering whether your Leucovorin has lactose, gluten, soy, a dye or gelatin in it? The medicine is the same, but the fillers, coatings and colors differ from one company to the next. This page shows what each Leucovorin product's FDA label lists, so you can find a version that leaves out what you avoid and ask your pharmacist for it by its NDC.

We have read the FDA labels of 57 of the 59 current Leucovorin products on the market today, from 17 companies listing it with the FDA, and lined them up side by side. 2 are still being read and will appear on a later visit.

Ask about your bottle

Is there something in your Leucovorin? Ask in plain words.

Name the company, strength or the NDC on your bottle and the ingredient you avoid. The answer comes only from the FDA labels on this page.

Answers are drawn from the FDA label data on this page and checked against it. They are not medical advice: confirm with your pharmacist before relying on them.

The short answer

Which Leucovorin products list lactose, a gluten source, soy, dyes or gelatin?

  1. LactoseDiffers by manufacturer

    12 of 57 checked products list lactose; 45 do not. See the products

    Does not list it Avyxa BluePoint Fresenius Kabi Gland Glenmark Hikma Leading Meitheal Mylan Institutional Proficient Rx Sagent Slate Run
    Lists it American Health Packaging Epic Ingenus Major Teva
  2. Wheat or gluten sourceNo checked product

    No checked Leucovorin product lists a wheat or gluten source.

  3. SoyNo checked product

    No checked Leucovorin product lists soy.

  4. Synthetic dyesDiffers by manufacturer

    7 of 57 checked products list synthetic dyes; 50 do not. See the products

    Does not list it Avyxa BluePoint Epic Fresenius Kabi Gland Glenmark Hikma Ingenus Leading Meitheal Mylan Institutional Proficient Rx Sagent Slate Run Teva
    Lists it American Health Packaging Hikma Ingenus Major Teva
  5. GelatinNo checked product

    No checked Leucovorin product lists gelatin.

Also listed by some products: Corn 10 of 57

Find a version without it

Every current Leucovorin product and what its label lists

Hide products that list:

ProductListsInactive ingredients on the label
American Health Packaging 1 product
25 mg tabletNDC 60687-0227-94 Lactose Synthetic dyes
Show 7 ingredients

CROSCARMELLOSE SODIUM, D&C YELLOW NO. 10 ALUMINUM LAKE, FD&C BLUE NO. 1--ALUMINUM LAKE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE
Avyxa Pharma, LLC 3 products
50 mg/5 mL injectionNDC 83831-0147-05 None of these listed
Show 5 ingredients

BETADEX SULFOBUTYL ETHER SODIUM, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, TROMETHAMINE
350 mg/35 mL injectionNDC 83831-0148-35 None of these listed
Show 5 ingredients

BETADEX SULFOBUTYL ETHER SODIUM, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, TROMETHAMINE
500 mg/50 mL injectionNDC 83831-0149-50 None of these listed
Show 5 ingredients

BETADEX SULFOBUTYL ETHER SODIUM, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, TROMETHAMINE
BluePoint Laboratories 6 products
100 mg/10 mL injectionNDC 68001-0416-36 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
100 mg/10 mL injectionNDC 68001-0648-36 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
200 mg/20 mL injectionNDC 68001-0417-37 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
200 mg/20 mL injectionNDC 68001-0649-37 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
350 mg/17.5 mL injectionNDC 68001-0418-38 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
350 mg/17.5 mL injectionNDC 68001-0650-38 Still being read Not read yet
Epic Pharma LLC 4 products
5 mg tabletNDC 42806-0358-01 Lactose
Show 5 ingredients

ANHYDROUS LACTOSE, CROSCARMELLOSE SODIUM, MAGNESIUM PALMITOSTEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE
10 mg tabletNDC 42806-0133-21 Lactose
Show 5 ingredients

ANHYDROUS LACTOSE, CROSCARMELLOSE SODIUM, MAGNESIUM PALMITOSTEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE
15 mg tabletNDC 42806-0134-24 Lactose
Show 5 ingredients

ANHYDROUS LACTOSE, CROSCARMELLOSE SODIUM, MAGNESIUM PALMITOSTEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE
25 mg tabletNDC 42806-0359-25 Lactose
Show 5 ingredients

ANHYDROUS LACTOSE, CROSCARMELLOSE SODIUM, MAGNESIUM PALMITOSTEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE
Fresenius Kabi USA, LLC 3 products
10 mg/mL injectionNDC 63323-0631-10 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
200 mg/20 mL injectionNDC 63323-0710-50 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
500 mg/50 mL injectionNDC 63323-0711-00 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Gland Pharma Limited 1 product
350 mg/17.5 mL injectionNDC 68083-0587-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, SODIUM HYDROXIDE
Glenmark Pharmaceuticals Inc., Usa 1 product
350 mg/17.5 mL injectionNDC 68462-0767-35 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, SODIUM HYDROXIDE
Hikma Pharmaceuticals USA Inc. 10 products
50 mg/5 mL injectionNDC 00143-9555-01 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
100 mg/10 mL injectionNDC 00143-9554-01 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
200 mg/20 mL injectionNDC 00143-9368-01 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
200 mg/20 mL injectionNDC 00143-9553-01 Still being read Not read yet
350 mg/17.5 mL injectionNDC 00143-9552-01 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
5 mg tabletNDC 00054-4496-13 Corn-derived
Show 6 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POVIDONE, UNSPECIFIED, SILICON DIOXIDE, STARCH, CORN
5 mg tabletNDC 00054-8496-19 Corn-derived
Show 5 ingredients

CROSCARMELLOSE SODIUM, MICROCRYSTALLINE CELLULOSE, POVIDONE, UNSPECIFIED, SILICON DIOXIDE, STARCH, CORN
10 mg tabletNDC 00054-4497-05 Corn-derived
Show 6 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POVIDONE, UNSPECIFIED, SILICON DIOXIDE, STARCH, CORN
15 mg tabletNDC 00054-4498-10 Corn-derived Synthetic dyes
Show 7 ingredients

CROSCARMELLOSE SODIUM, D&C YELLOW NO. 10, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POVIDONE, UNSPECIFIED, SILICON DIOXIDE, STARCH, CORN
25 mg tabletNDC 00054-4499-11 Corn-derived Synthetic dyes
Show 7 ingredients

CROSCARMELLOSE SODIUM, D&C YELLOW NO. 10, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POVIDONE, UNSPECIFIED, SILICON DIOXIDE, STARCH, CORN
Ingenus Pharmaceuticals, LLC 4 products
5 mg tabletNDC 50742-0181-01 Lactose
Show 6 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, SILICON DIOXIDE
10 mg tabletNDC 50742-0182-12 Lactose
Show 6 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, SILICON DIOXIDE
15 mg tabletNDC 50742-0183-24 Lactose Synthetic dyes
Show 7 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, CROSCARMELLOSE SODIUM, FD&C YELLOW NO. 6, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, SILICON DIOXIDE
25 mg tabletNDC 50742-0184-25 Lactose Synthetic dyes
Show 7 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, CROSCARMELLOSE SODIUM, FD&C YELLOW NO. 6, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, SILICON DIOXIDE
Leading Pharma, LLC 4 products
5 mg tabletNDC 69315-0184-01 Corn-derived
Show 5 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE, STARCH, CORN
10 mg tabletNDC 69315-0185-12 Corn-derived
Show 5 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE, STARCH, CORN
15 mg tabletNDC 69315-0186-24 Corn-derived
Show 5 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE, STARCH, CORN
25 mg tabletNDC 69315-0187-25 Corn-derived
Show 5 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE, STARCH, CORN
Major Pharmaceuticals 1 product
25 mg tabletNDC 00904-7584-10 Lactose Synthetic dyes
Show 7 ingredients

ANHYDROUS LACTOSE, CROSCARMELLOSE SODIUM, FD&C YELLOW NO. 6, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE
Meitheal Pharmaceuticals Inc. 5 products
50 mg/5 mL injectionNDC 71288-0160-10 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
100 mg/10 mL injectionNDC 71288-0161-20 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
200 mg/20 mL injectionNDC 71288-0162-30 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
350 mg/17.5 mL injectionNDC 71288-0163-30 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
500 mg/50 mL injectionNDC 71288-0164-50 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Mylan Institutional LLC 3 products
100 mg/10 mL injectionNDC 67457-0528-10 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
200 mg/20 mL injectionNDC 67457-0529-20 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
350 mg/17.5 mL injectionNDC 67457-0530-35 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Proficient Rx LP 1 product
5 mg tabletNDC 71205-0908-00 Corn-derived
Show 5 ingredients

CROSCARMELLOSE SODIUM, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, SILICON DIOXIDE, STARCH, CORN
Sagent Pharmaceuticals 5 products
50 mg/5 mL injectionNDC 25021-0813-10 None of these listed
Show 3 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide
100 mg/10 mL injectionNDC 25021-0814-30 None of these listed
Show 3 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide
200 mg/20 mL injectionNDC 25021-0815-30 None of these listed
Show 3 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide
350 mg/17.5 mL injectionNDC 25021-0816-30 None of these listed
Show 3 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide
500 mg/50 mL injectionNDC 25021-0828-50 None of these listed
Show 3 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide
Slate Run Pharmaceuticals, LLC 5 products
50 mg injectionNDC 70436-0116-82 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
100 mg injectionNDC 70436-0117-80 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
200 mg injectionNDC 70436-0118-80 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
350 mg injectionNDC 70436-0119-80 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
500 mg injectionNDC 70436-0120-80 None of these listed
Show 1 ingredient

SODIUM CHLORIDE
Teva Pharmaceuticals USA, Inc. 2 products
5 mg tabletNDC 00555-0484-01 Lactose
Show 5 ingredients

CELLULOSE, MICROCRYSTALLINE, CROSCARMELLOSE SODIUM, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, SILICON DIOXIDE
25 mg tabletNDC 00555-0485-04 Lactose Synthetic dyes
Show 7 ingredients

CELLULOSE, MICROCRYSTALLINE, CROSCARMELLOSE SODIUM, D&C YELLOW NO. 10 ALUMINUM LAKE, FD&C BLUE NO. 1 ALUMINUM LAKE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, SILICON DIOXIDE

A product with none of these listed is not certified to be without them: the label says what the manufacturer declared, and the source of a starch or a flavor is often not stated. The companies are the FDA's labelers, which include repackagers and distributors selling another company's product under their own label. The NDC opens the product's own page, with the full label and its inactive-ingredient notes.

Leucovorin without lactose

Lactose: milk sugar; a concern with lactose intolerance or a milk allergy. 12 of 57 checked products list lactose; 45 do not.

Does not list lactose

Lists lactose

Leucovorin without synthetic dyes

Synthetic dyes: FD&C or D&C colorants and their aluminum lakes. 7 of 57 checked products list synthetic dyes; 50 do not.

Does not list synthetic dyes

Lists synthetic dyes

Leucovorin without corn-derived ingredients

Corn-derived: corn starch, maize or corn syrup; a concern with corn allergy. 10 of 57 checked products list corn-derived ingredients; 47 do not.

Does not list corn-derived ingredients

Lists corn-derived ingredients

At the pharmacy counter

How to use this at the pharmacy counter

  1. Pick the company whose list suits you and copy the NDC from the table. Many pharmacies order from wholesalers that carry several companies' versions and can request a particular one if you ask before the prescription is filled; some buy from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check.
  2. Treat "does not list" as exactly that. The label is what the manufacturer declared; a flavor or a starch may have an unstated source, and lines change. For celiac disease or a serious allergy, ask the manufacturer's medical information line for a written statement about the lot you have.
  3. Check the bottle each refill. A different company usually means a different shape, color and inactive-ingredient list; the pharmacist can tell you who made it, and the two-NDC comparison shows the difference line by line.
  4. If you need one company's version kept constant, ask your prescriber to write that company or the NDC on the prescription and tell the pharmacy you need it held. Rules vary by state and plan, so confirm with the pharmacist.
Ask Dr. Staiger which Leucovorin product suits you →

Common questions about Leucovorin inactive ingredients

Is Leucovorin gluten-free?
This page cannot certify any Leucovorin product gluten-free; it reports what each label declares. Of the 57 products checked, none lists a wheat, barley, rye or gluten ingredient, and none lists a starch without a stated source. If you have celiac disease, ask the manufacturer's medical information line for a written gluten statement for the lot you have.
Does Leucovorin contain lactose?
12 of 57 checked Leucovorin products list lactose; 45 do not: Avyxa (50 mg/5 mL injection, 350 mg/35 mL injection and 500 mg/50 mL injection), BluePoint (100 mg/10 mL injection, 200 mg/20 mL injection and 350 mg/17.5 mL injection), Fresenius Kabi (10 mg/mL injection, 200 mg/20 mL injection and 500 mg/50 mL injection) and Gland (350 mg/17.5 mL injection) and 8 other companies. The lactose in a tablet or capsule is a small amount, but people with a milk allergy or a strong intolerance often prefer a version that does not list it.
Does Leucovorin contain soy?
No checked Leucovorin product lists a soy ingredient (soybean oil or soy lecithin) on its label. Soy lecithin is the usual form and the amount is small, but people with a soy allergy often prefer a version that does not list it.
Is there a dye-free Leucovorin?
7 of 57 checked Leucovorin products list a synthetic dye (an FD&C or D&C colorant); 50 do not: Avyxa (50 mg/5 mL injection, 350 mg/35 mL injection and 500 mg/50 mL injection), BluePoint (100 mg/10 mL injection, 200 mg/20 mL injection and 350 mg/17.5 mL injection), Epic (5 mg tablet, 10 mg tablet and 15 mg tablet and 1 more) and Fresenius Kabi (10 mg/mL injection, 200 mg/20 mL injection and 500 mg/50 mL injection) and 11 other companies. Colorants often differ by strength within one company's line, so compare the lists above strength by strength.
Does Leucovorin contain gelatin?
No checked Leucovorin product lists gelatin on its label. Gelatin is usually bovine or porcine and the label rarely says which; for kosher, halal or vegetarian needs, ask the manufacturer.
Why do the inactive ingredients differ between manufacturers?
A generic must match the brand's active ingredient, strength, dose form and how it is absorbed; its fillers, binders, coatings and colorants are the manufacturer's own choice. That is why one Leucovorin product can list lactose and a dye while another from a different company lists neither.
Can my pharmacy give me a specific manufacturer's version?
Often, if you ask before the prescription is filled: many pharmacies order from wholesalers that carry several companies' versions and can request a particular one. Some pharmacies buy a generic from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check. Give them the NDC from this page; the company name alone is often enough.
How current is this list?
The products are the ones in the FDA's current NDC directory as of October 6, 2026, and each inactive-ingredient list is the manufacturer's FDA label as our label sync last read it. Formulations change, so check the label on your own bottle and ask your pharmacist if a refill looks different.

Sources: the products are the finished Leucovorin products in the FDA's current NDC directory (openFDA), as of October 6, 2026; each inactive-ingredient list is the manufacturer's FDA Structured Product Label via DailyMed, as our label sync last read it. The concern groups are HelloPharmacist's classification of the names the label declares. Educational information only, not medical advice; confirm with your pharmacist before relying on a list. ← Back to the Leucovorin guide