Salsalate

Generic name: Pronounced as (sal' sa late)
Brand names
  • Disalcid®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 09/15/2017

People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as salsalate may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart disease, heart failure, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take salsalate right before or right after the surgery.

NSAIDs such as salsalate may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, smoke, or drink large amounts of alcohol while taking salsalate. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin; other NSAIDS such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); or oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone). Also tell your doctor if you have or have ever had ulcers, bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking salsalate and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to salsalate. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with salsalate and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Salsalate is used to relieve pain, tenderness, swelling, and stiffness caused by rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), osteoarthritis (arthritis caused by a breakdown of the lining of the joints), and other conditions that cause swelling. Salsalate is in a class of nonsteroidal anti-inflammatory medications (NSAIDs) called salicylates. It works by stopping the body's production of a substance that causes pain, fever, and swelling.

Salsalate comes as a tablet to take by mouth. It is usually taken two to three times a day. Salsalate may be taken with food or milk to prevent stomach upset. Take salsalate at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take salsalate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

It may take three to four days until you feel the full benefit of the medication. If your symptoms do not improve or get worse, call your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking salsalate,

  • tell your doctor and pharmacist if you are allergic to salsalate, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the ingredients in salsalate tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: acetazolamide (Diamox); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); antacids; diuretics (''water pills'') such as furosemide (Lasix); lithium (Eskalith, Lithobid);medications for gout such as probenecid (Probalan) and sulfinpyrazone (Anturane); methazolamide; certain oral medications for diabetes such as chlorpropamide (Diabinese), glimepiride (Amaryl, in Avandaryl), glipizide (Glucotrol, in Metaglip),glyburide (Diabeta, Glynase, Micronase), tolazamide (Tolinase), and tolbutamide;certain medications for seizures such as phenytoin (Dilantin, Phenytek) and valproic acid (Depakene, Depakote); methotrexate (Trexall); penicillin (Veetids); salicylates such as bismuth subsalicylate (Kaopectate, Pepto-Bismol), choline magnesium trisalicylatecholine salicylate (Arthropan), diflunisal (Dolobid), and magnesium salicylate (Doan's, others); and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had any of the conditions in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); gout; kidney or liver disease; or swelling of the hands, feet, ankles or lower legs.

  • you should know that salsalate should not be taken by children and teenagers who have chicken pox, flu, flu symptoms, or who have received the varicella virus (chicken pox) vaccine in the past six weeks because of the risk of Reye's Syndrome (a serious condition in which fat builds up on the brain, liver, and other body organs).

  • tell your doctor if you are pregnant, especially if you are in the last few months of pregnancy; plan to become pregnant; or are breast-feeding. If you become pregnant while taking salsalate, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking salsalate.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Salsalate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • dizziness

  • Some side effects can be serious. If you experience any of the following symptoms, or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • ringing in the ears

    • loss of hearing

    • difficulty breathing or swallowing

    • shortness of breath

    • hoarseness

    • fast heartbeat

    • unexplained weight gain

    • swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs

    • rash

    • hives

    • blisters

    • itching

    • unusual bleeding or bruising

    • pale or cold skin

    • fever

    • nausea

    • headache

    • extreme tiredness

    • weakness

    • lack of energy

    • loss of appetite

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • flu-like symptoms

    • cloudy, discolored, or bloody urine

    • back pain

    • difficult or painful urination

  • Salsalate may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

  • ringing in the ears

  • dizziness

  • headache

  • confusion

  • extreme tiredness

  • sweating

  • rapid breathing

  • extreme thirst

  • muscle cramps

  • fainting

  • flushing

  • loss of consciousness

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking salsalate.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

  • Disalicylic Acid
  • Salicylsalicylic Acid

Drug Interaction
Moxifloxacin Moxifloxacin Salsalate may increase the neuroexcitatory activities of Moxifloxacin.
Alendronate Alendronate The risk or severity of adverse effects can be increased when Salsalate is combined with Alendronic acid.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Salsalate is combined with Anagrelide.
Candesartan Candesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Candesartan is combined with Salsalate.
Cilostazol Cilostazol The risk or severity of bleeding can be increased when Salsalate is combined with Cilostazol.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Salsalate is combined with Clopidogrel.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Salsalate may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate Fenofibrate Salsalate may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The therapeutic efficacy of Guanfacine can be decreased when used in combination with Salsalate.
Magnesium Hydroxide Magnesium Hydroxide Salsalate may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine Methylergonovine The risk or severity of hypertension can be increased when Methylergometrine is combined with Salsalate.
Mycophenolate Mycophenolate Salsalate may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Salsalate.
Olsalazine Olsalazine The therapeutic efficacy of Olsalazine can be decreased when used in combination with Salsalate.
Penbutolol Penbutolol Salsalate may decrease the antihypertensive activities of Acebutolol.
Potassium Potassium Potassium cation may decrease the excretion rate of Salsalate which could result in a higher serum level.
Prednisone Prednisone The risk or severity of gastrointestinal irritation can be increased when Salsalate is combined with Prednisone.
Ranitidine Ranitidine Salsalate may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The therapeutic efficacy of Reserpine can be decreased when used in combination with Salsalate.
Rizatriptan Rizatriptan Salsalate may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan Sumatriptan Salsalate may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus Tacrolimus The risk or severity of renal failure can be increased when Salsalate is combined with Tacrolimus.
Tiludronate Tiludronate The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Etidronic acid.
Triamcinolone Triamcinolone The risk or severity of gastrointestinal irritation can be increased when Triamcinolone is combined with Salsalate.
Zolmitriptan Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Salsalate.
Ampicillin Injection Ampicillin Injection Salsalate may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Salsalate may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Salsalate may decrease the excretion rate of Fluconazole which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Foscarnet.
Hydromorphone Injection Hydromorphone Injection Salsalate may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Levofloxacin Injection Levofloxacin Injection Salsalate may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection Salsalate may decrease the excretion rate of Meperidine which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone is combined with Salsalate.
Metoclopramide Injection Metoclopramide Injection Salsalate may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Pamidronic acid.
Vancomycin Injection Vancomycin Injection Salsalate may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of bleeding can be increased when Zidovudine is combined with Salsalate.
Altretamine Altretamine Salsalate may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Cefuroxime Cefuroxime The risk or severity of nephrotoxicity can be increased when Cefuroxime is combined with Salsalate.
Cyclosporine Cyclosporine The risk or severity of renal failure and hypertension can be increased when Salsalate is combined with Cyclosporine.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Enoxaparin.
Torsemide Torsemide The therapeutic efficacy of Torasemide can be decreased when used in combination with Salsalate.
Eprosartan Eprosartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Eprosartan is combined with Salsalate.
Meloxicam Meloxicam The risk or severity of adverse effects can be increased when Meloxicam is combined with Salsalate.
Pantoprazole Pantoprazole Salsalate may decrease the excretion rate of Pantoprazole which could result in a higher serum level.
Risedronate Risedronate The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Risedronic acid.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Salsalate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Telmisartan is combined with Salsalate.
Temozolomide Temozolomide Salsalate may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon Salsalate may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Linezolid Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Salsalate.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Pentosan polysulfate.
Trimipramine Trimipramine The risk or severity of hypertension can be increased when Trimipramine is combined with Salsalate.
Perindopril Perindopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Perindopril.
Tenofovir Tenofovir Salsalate may increase the nephrotoxic activities of Tenofovir.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of adverse effects can be increased when Salsalate is combined with Choline magnesium trisalicylate.
Dutasteride Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Salsalate.
Epinephrine Injection Epinephrine Injection The risk or severity of hypertension can be increased when Epinephrine is combined with Salsalate.
Eplerenone Eplerenone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Eplerenone.
Escitalopram Escitalopram The risk or severity of gastrointestinal bleeding can be increased when Escitalopram is combined with Salsalate.
Olmesartan Olmesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Olmesartan is combined with Salsalate.
Zonisamide Zonisamide Salsalate may decrease the excretion rate of Zonisamide which could result in a higher serum level.
Aripiprazole Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Salsalate.
Atomoxetine Atomoxetine Salsalate may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Dexmethylphenidate Dexmethylphenidate The risk or severity of hypertension can be increased when Salsalate is combined with Dexmethylphenidate.
Atazanavir Atazanavir The risk or severity of nephrotoxicity can be increased when Atazanavir is combined with Salsalate.
Almotriptan Almotriptan Salsalate may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Eletriptan Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Salsalate.
Emtricitabine Emtricitabine Salsalate may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Salsalate may decrease the excretion rate of Memantine which could result in a higher serum level.
Tadalafil Tadalafil Salsalate may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Salsalate.
Gemifloxacin Gemifloxacin Salsalate may increase the neuroexcitatory activities of Gemifloxacin.
Protriptyline Protriptyline The risk or severity of hypertension can be increased when Protriptyline is combined with Salsalate.
Duloxetine Duloxetine The risk or severity of gastrointestinal bleeding can be increased when Duloxetine is combined with Salsalate.
Tinidazole Tinidazole Salsalate may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan Bosentan The therapeutic efficacy of Bosentan can be decreased when used in combination with Salsalate.
Cefditoren Cefditoren Salsalate may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Salsalate may decrease the excretion rate of Hydroxocobalamin which could result in a higher serum level.
Eszopiclone Eszopiclone Salsalate may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Ganciclovir Ganciclovir Salsalate may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Salsalate may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin The risk or severity of hypertension can be increased when Salsalate is combined with Solifenacin.
Valganciclovir Valganciclovir Salsalate may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Zoledronic Acid Injection Zoledronic Acid Injection The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Zoledronic acid.
Adefovir Adefovir The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Adefovir.
Dextroamphetamine Dextroamphetamine Salsalate may decrease the excretion rate of Amphetamine which could result in a higher serum level.
Ibandronate Ibandronate The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Ibandronate.
Isocarboxazid Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Salsalate.
Ramelteon Ramelteon Salsalate may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Fentanyl Fentanyl Fentanyl may decrease the excretion rate of Salsalate which could result in a higher serum level.
Pregabalin Pregabalin Salsalate may decrease the excretion rate of Pregabalin which could result in a higher serum level.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Salsalate is combined with Deferasirox.
Phenylephrine Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Salsalate.
Ranolazine Ranolazine Salsalate may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline Rasagiline Salsalate may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Sitagliptin Sitagliptin Salsalate may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Salsalate may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Salsalate may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone Salsalate may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Clofarabine Injection Clofarabine Injection Salsalate may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Lubiprostone Lubiprostone Salsalate may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren Aliskiren The risk or severity of renal failure and hypertension can be increased when Salsalate is combined with Aliskiren.
Bismuth Subsalicylate Bismuth Subsalicylate The therapeutic efficacy of Bismuth subsalicylate can be decreased when used in combination with Salsalate.
Pemetrexed Injection Pemetrexed Injection Salsalate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Salsalate.
Sorafenib Sorafenib Salsalate may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Levocetirizine Levocetirizine Salsalate may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Salsalate may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Salsalate may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Salsalate may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide Budesonide The risk or severity of gastrointestinal irritation can be increased when Salsalate is combined with Budesonide.
Desmopressin Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Salsalate is combined with Desmopressin.
Doripenem Injection Doripenem Injection Salsalate may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Salsalate may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of gastrointestinal bleeding can be increased when Desvenlafaxine is combined with Salsalate.
Cevimeline Cevimeline Salsalate may decrease the excretion rate of Cevimeline which could result in a higher serum level.
Nebivolol Nebivolol Salsalate may decrease the antihypertensive activities of Nebivolol.
Certolizumab Injection Certolizumab Injection Salsalate may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Salsalate may decrease the excretion rate of Daptomycin which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Salsalate may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Midazolam Midazolam Salsalate may decrease the excretion rate of Midazolam which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection Salsalate may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of gastrointestinal bleeding can be increased when Milnacipran is combined with Salsalate.
Plerixafor Injection Plerixafor Injection Salsalate may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate Sodium Phosphate The risk or severity of renal failure can be increased when Sodium phosphate, monobasic is combined with Salsalate.
Fesoterodine Fesoterodine Salsalate may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Betaxolol Betaxolol Salsalate may decrease the antihypertensive activities of Betaxolol.
Iloperidone Iloperidone The risk or severity of hypertension can be increased when Salsalate is combined with Iloperidone.
Prasugrel Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Prasugrel.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The risk or severity of hyperkalemia can be increased when Salsalate is combined with Tolvaptan.
Dronedarone Dronedarone The risk or severity of hypertension can be increased when Salsalate is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Salsalate may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection Salsalate may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Saxagliptin Saxagliptin Salsalate may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Salsalate may decrease the excretion rate of Telavancin which could result in a higher serum level.
Topotecan Topotecan Salsalate may decrease the excretion rate of Topotecan which could result in a higher serum level.
Asenapine Asenapine The risk or severity of hypertension can be increased when Salsalate is combined with Asenapine.
Dabigatran Dabigatran The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Dabigatran.
Dalfampridine Dalfampridine Salsalate may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Ceftaroline Injection Ceftaroline Injection The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Ceftaroline fosamil.
Lurasidone Lurasidone The risk or severity of hypertension can be increased when Salsalate is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection The risk or severity of adverse effects can be increased when Acetaminophen is combined with Salsalate.
Vilazodone Vilazodone The risk or severity of hypertension can be increased when Salsalate is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Salsalate may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Salsalate may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Salsalate may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Azilsartan Azilsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Azilsartan medoxomil is combined with Salsalate.
Roflumilast Roflumilast Salsalate may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Salsalate.
Rivaroxaban Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Rivaroxaban.
Ticagrelor Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Ticagrelor.
Ruxolitinib Ruxolitinib Salsalate may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam Salsalate may decrease the excretion rate of Clobazam which could result in a higher serum level.
Deferiprone Deferiprone Salsalate may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Salsalate.
Naloxone Injection Naloxone Injection Salsalate may decrease the excretion rate of Naloxone which could result in a higher serum level.
Ambrisentan Ambrisentan The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Salsalate.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Fondaparinux.
Iloprost Iloprost The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Iloprost.
Enzalutamide Enzalutamide Salsalate may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Salsalate may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of gastrointestinal irritation can be increased when Corticotropin is combined with Salsalate.
Teduglutide Injection Teduglutide Injection Salsalate may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Salsalate is combined with Icosapent ethyl.
Alogliptin Alogliptin Salsalate may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide Salsalate may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Apixaban Apixaban The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Apixaban.
Canagliflozin Canagliflozin Salsalate may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Trametinib Trametinib Salsalate may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of gastrointestinal bleeding can be increased when Levomilnacipran is combined with Salsalate.
Ertapenem Injection Ertapenem Injection Salsalate may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine Vortioxetine Salsalate may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Ketorolac Injection Ketorolac Injection The risk or severity of adverse effects can be increased when Ketorolac is combined with Salsalate.
Sofosbuvir Sofosbuvir Salsalate may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Apremilast Apremilast Salsalate may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Salsalate may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Testosterone Injection Testosterone Injection Salsalate may decrease the excretion rate of Testosterone which could result in a higher serum level.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Vorapaxar.
Edoxaban Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Edoxaban.
Methamphetamine Methamphetamine Salsalate may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Tasimelteon Tasimelteon Salsalate may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Riociguat Riociguat The therapeutic efficacy of Riociguat can be decreased when used in combination with Salsalate.
Risperidone Injection Risperidone Injection The risk or severity of hypertension can be increased when Risperidone is combined with Salsalate.
Haloperidol Injection Haloperidol Injection The therapeutic efficacy of Haloperidol can be increased when used in combination with Salsalate.
Amiloride Amiloride The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Amiloride.
Macitentan Macitentan The therapeutic efficacy of Macitentan can be decreased when used in combination with Salsalate.
Flibanserin Flibanserin The risk or severity of hypertension can be increased when Salsalate is combined with Flibanserin.
Prednisolone Prednisolone The risk or severity of gastrointestinal irritation can be increased when Prednisolone is combined with Salsalate.
Brexpiprazole Brexpiprazole The risk or severity of hypertension can be increased when Salsalate is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of hypertension can be increased when Ziprasidone is combined with Salsalate.
Cariprazine Cariprazine The risk or severity of hypertension can be increased when Salsalate is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Salsalate may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Ixazomib Ixazomib Salsalate may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Salsalate may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Salsalate.
Dexamethasone Injection Dexamethasone Injection The risk or severity of gastrointestinal irritation can be increased when Dexamethasone is combined with Salsalate.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Defibrotide.
Brivaracetam Injection Brivaracetam Injection Salsalate may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Midodrine Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Salsalate.
Selexipag Selexipag The therapeutic efficacy of Selexipag can be decreased when used in combination with Salsalate.
Furosemide Injection Furosemide Injection The therapeutic efficacy of Furosemide can be decreased when used in combination with Salsalate.
Lixisenatide Injection Lixisenatide Injection Salsalate may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may decrease the excretion rate of Salsalate which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Salsalate may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Salsalate may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of gastrointestinal irritation can be increased when Deflazacort is combined with Salsalate.
Safinamide Safinamide The risk or severity of hypertension can be increased when Salsalate is combined with Safinamide.
Naldemedine Naldemedine Salsalate may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Salsalate may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Salsalate may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Salsalate.
Apalutamide Apalutamide Salsalate may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Salsalate may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Lofexidine can be decreased when used in combination with Salsalate.
Plazomicin Injection Plazomicin Injection Salsalate may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol The risk or severity of hypertension can be increased when Salsalate is combined with Cannabidiol.
Stiripentol Stiripentol Salsalate may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Prucalopride Prucalopride Salsalate may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Siponimod Siponimod The risk or severity of hypertension can be increased when Salsalate is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Salsalate may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Salsalate is combined with Caplacizumab.
Solriamfetol Solriamfetol The risk or severity of hypertension can be increased when Solriamfetol is combined with Salsalate.
Pitolisant Pitolisant The risk or severity of adverse effects can be increased when Salsalate is combined with Pitolisant.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be increased when it is combined with Salsalate.
Selpercatinib Selpercatinib The risk or severity of hypertension can be increased when Salsalate is combined with Selpercatinib.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection The risk or severity of hypertension can be increased when Salsalate is combined with Naxitamab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The risk or severity of hyperkalemia can be increased when Salsalate is combined with Drospirenone.
Viloxazine Viloxazine Salsalate may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Salsalate may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Fenoprofen Fenoprofen The risk or severity of adverse effects can be increased when Fenoprofen is combined with Salsalate.
Indomethacin Indomethacin The risk or severity of adverse effects can be increased when Indomethacin is combined with Salsalate.
Mefenamic Acid Mefenamic Acid The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Salsalate.
Naproxen Naproxen The risk or severity of adverse effects can be increased when Naproxen is combined with Salsalate.
Tolmetin Tolmetin The risk or severity of adverse effects can be increased when Tolmetin is combined with Salsalate.
Sulindac Sulindac The risk or severity of adverse effects can be increased when Sulindac is combined with Salsalate.
Trazodone Trazodone The risk or severity of gastrointestinal bleeding can be increased when Trazodone is combined with Salsalate.
Isotretinoin Isotretinoin Salsalate may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Salsalate may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine Floxuridine Salsalate may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Metaxalone Metaxalone Salsalate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The serum concentration of Methotrexate can be increased when it is combined with Salsalate.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Salsalate is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Salsalate.
Chlorpromazine Chlorpromazine Salsalate may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Diazepam Diazepam Salsalate may decrease the excretion rate of Diazepam which could result in a higher serum level.
Oxazepam Oxazepam Salsalate may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Flurazepam Flurazepam Salsalate may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate Clorazepate Salsalate may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam Lorazepam Salsalate may decrease the excretion rate of Lorazepam which could result in a higher serum level.
Phenoxybenzamine Phenoxybenzamine The therapeutic efficacy of Phenoxybenzamine can be decreased when used in combination with Salsalate.
Carmustine Carmustine Salsalate may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine Amantadine Salsalate may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine Codeine Salsalate may decrease the excretion rate of Codeine which could result in a higher serum level.
Bromocriptine Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Salsalate.
Metaproterenol Metaproterenol The risk or severity of hypertension can be increased when Orciprenaline is combined with Salsalate.
Tranylcypromine Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Salsalate.
Phenelzine Phenelzine Salsalate may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Salsalate.
Tetracycline Tetracycline Salsalate may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Thioridazine Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Salsalate.
Trifluoperazine Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Salsalate.
Bleomycin Bleomycin Salsalate may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine Sulfadiazine Salsalate may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Methadone Methadone Salsalate may decrease the excretion rate of Methadone which could result in a higher serum level.
Benztropine Benztropine Salsalate may decrease the excretion rate of Benzatropine which could result in a higher serum level.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Salsalate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Salsalate may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Ibuprofen Ibuprofen The risk or severity of adverse effects can be increased when Ibuprofen is combined with Salsalate.
Azathioprine Azathioprine Salsalate may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Phentermine Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Salsalate.
Methylphenidate Methylphenidate Salsalate may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of hypertension can be increased when Amoxapine is combined with Salsalate.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Sulfasalazine can be decreased when used in combination with Salsalate.
Hydrocortisone Hydrocortisone The risk or severity of gastrointestinal irritation can be increased when Hydrocortisone is combined with Salsalate.
Phenazopyridine Phenazopyridine The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Phenazopyridine.
Carbamazepine Carbamazepine Salsalate may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Methyldopa Methyldopa The therapeutic efficacy of Methyldopa can be decreased when used in combination with Salsalate.
Clonidine Clonidine The therapeutic efficacy of Clonidine can be decreased when used in combination with Salsalate.
Prazosin Prazosin The therapeutic efficacy of Prazosin can be decreased when used in combination with Salsalate.
Hydralazine Hydralazine Salsalate may decrease the antihypertensive activities of Hydralazine.
Cimetidine Cimetidine Salsalate may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Salsalate may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Warfarin Warfarin The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Warfarin.
Clonazepam Clonazepam Salsalate may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide Loperamide The risk or severity of hyperkalemia can be increased when Loperamide is combined with Salsalate.
Promethazine Promethazine Salsalate may decrease the excretion rate of Promethazine which could result in a higher serum level.
Meclofenamate Meclofenamate The risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Salsalate.
Nitrofurantoin Nitrofurantoin Salsalate may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Salsalate may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Salsalate may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Salsalate.
Triamterene Triamterene The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Triamterene.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Salsalate is combined with Sulfinpyrazone.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be decreased when used in combination with Salsalate.
Chlorthalidone Chlorthalidone The therapeutic efficacy of Chlorthalidone can be decreased when used in combination with Salsalate.
Metolazone Metolazone The therapeutic efficacy of Metolazone can be decreased when used in combination with Salsalate.
Secobarbital Secobarbital Salsalate may decrease the excretion rate of Secobarbital which could result in a higher serum level.
Desipramine Desipramine Desipramine may decrease the excretion rate of Salsalate which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Salsalate which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Salsalate which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Salsalate which could result in a higher serum level.
Quinidine Quinidine Salsalate may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Salsalate may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Salsalate may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide Pyrazinamide Salsalate may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide Disopyramide Salsalate may decrease the excretion rate of Disopyramide which could result in a higher serum level.
Valproic Acid Valproic Acid The protein binding of Valproic acid can be decreased when combined with Salsalate.
Butabarbital Butabarbital Salsalate may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Liothyronine Liothyronine Salsalate may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole Methimazole Salsalate may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide The protein binding of Chlorpropamide can be decreased when combined with Salsalate.
Tolbutamide Tolbutamide The protein binding of Tolbutamide can be decreased when combined with Salsalate.
Tolazamide Tolazamide The protein binding of Tolazamide can be decreased when combined with Salsalate.
Baclofen Baclofen Salsalate may decrease the excretion rate of Baclofen which could result in a higher serum level.
Ethambutol Ethambutol Salsalate may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Methyclothiazide can be decreased when used in combination with Salsalate.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Hydrochlorothiazide can be decreased when used in combination with Salsalate.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Salsalate.
Chlorzoxazone Chlorzoxazone Salsalate may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Pyridoxine Pyridoxine Salsalate may decrease the excretion rate of Pyridoxine which could result in a higher serum level.
Folic Acid Folic Acid Salsalate may decrease the excretion rate of Folic acid which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Salsalate may decrease the antihypertensive activities of Propranolol.
Minoxidil Minoxidil The therapeutic efficacy of Minoxidil can be decreased when used in combination with Salsalate.
Pseudoephedrine Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Salsalate.
Nortriptyline Nortriptyline The risk or severity of hypertension can be increased when Nortriptyline is combined with Salsalate.
Spironolactone Spironolactone The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Spironolactone.
Amphotericin B Injection Amphotericin B Injection The risk or severity of nephrotoxicity can be increased when Amphotericin B is combined with Salsalate.
Phytonadione Phytonadione Salsalate may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Salsalate may decrease the excretion rate of Amikacin which could result in a higher serum level.
Nadolol Nadolol Salsalate may decrease the antihypertensive activities of Nadolol.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Salsalate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol Salsalate may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Flavoxate Flavoxate Salsalate may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Colchicine Colchicine Salsalate may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Salsalate may decrease the excretion rate of Cefaclor which could result in a higher serum level.
Cefadroxil Cefadroxil Salsalate may decrease the excretion rate of Cefadroxil which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection The risk or severity of nephrotoxicity can be increased when Cefazolin is combined with Salsalate.
Cephalexin Cephalexin Salsalate may decrease the excretion rate of Cephalexin which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection The risk or severity of nephrotoxicity can be increased when Cefoxitin is combined with Salsalate.
Dacarbazine Dacarbazine Salsalate may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Cefotaxime Injection Cefotaxime Injection The risk or severity of nephrotoxicity can be increased when Cefotaxime is combined with Salsalate.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salsalate may decrease the excretion rate of Salmon calcitonin which could result in a higher serum level.
Ketoconazole Ketoconazole The risk or severity of hyperkalemia can be increased when Ketoconazole is combined with Salsalate.
Pyrantel Pyrantel Salsalate may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Captopril Captopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Captopril.
Dipyridamole Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Dipyridamole.
Isoxsuprine Isoxsuprine The risk or severity of hypertension can be increased when Salsalate is combined with Isoxsuprine.
Ethacrynic Acid Ethacrynic Acid The therapeutic efficacy of Etacrynic acid can be decreased when used in combination with Salsalate.
Colistimethate Injection Colistimethate Injection The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Salsalate.
Metoprolol Metoprolol Salsalate may decrease the antihypertensive activities of Metoprolol.
Aspirin Aspirin The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Salsalate.
Alprazolam Alprazolam Salsalate may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Temazepam Temazepam Salsalate may decrease the excretion rate of Temazepam which could result in a higher serum level.
Triazolam Triazolam Salsalate may decrease the excretion rate of Triazolam which could result in a higher serum level.
Dicyclomine Dicyclomine Salsalate may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Propantheline Propantheline Salsalate may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim Trimethoprim Salsalate may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Salsalate.
Nifedipine Nifedipine Salsalate may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Salsalate may decrease the antihypertensive activities of Timolol.
Verapamil Verapamil Salsalate may decrease the excretion rate of Verapamil which could result in a higher serum level.
Atenolol Atenolol Salsalate may decrease the antihypertensive activities of Atenolol.
Pindolol Pindolol Salsalate may decrease the antihypertensive activities of Pindolol.
Cisplatin Injection Cisplatin Injection Salsalate may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Diflunisal can be decreased when used in combination with Salsalate.
Piroxicam Piroxicam The risk or severity of adverse effects can be increased when Piroxicam is combined with Salsalate.
Bumetanide Bumetanide The therapeutic efficacy of Bumetanide can be decreased when used in combination with Salsalate.
Glyburide Glyburide The protein binding of Glyburide can be decreased when combined with Salsalate.
Glipizide Glipizide The protein binding of Glipizide can be decreased when combined with Salsalate.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be decreased when used in combination with Salsalate.
Amoxicillin Amoxicillin Salsalate may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Salsalate may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline The risk or severity of bleeding can be increased when Salsalate is combined with Pentoxifylline.
Pentamidine Injection Pentamidine Injection The risk or severity of nephrotoxicity can be increased when Pentamidine is combined with Salsalate.
Ceftriaxone Injection Ceftriaxone Injection Salsalate may decrease the excretion rate of Ceftriaxone which could result in a higher serum level.
Labetalol Labetalol Salsalate may decrease the antihypertensive activities of Labetalol.
Auranofin Auranofin Salsalate may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Salsalate may decrease the excretion rate of Leuprolide which could result in a higher serum level.
Gemfibrozil Gemfibrozil Salsalate may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Guanabenz Guanabenz The therapeutic efficacy of Guanabenz can be decreased when used in combination with Salsalate.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Salsalate.
Ceftazidime Injection Ceftazidime Injection Salsalate may decrease the excretion rate of Ceftazidime which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Salsalate.
Cefotetan Injection Cefotetan Injection Salsalate may decrease the excretion rate of Cefotetan which could result in a higher serum level.
Enalapril Enalapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Enalapril.
Flurbiprofen Flurbiprofen The risk or severity of adverse effects can be increased when Flurbiprofen is combined with Salsalate.
Amiodarone Amiodarone The risk or severity of hyperkalemia can be increased when Amiodarone is combined with Salsalate.
Aztreonam Injection Aztreonam Injection Salsalate may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone Buspirone Salsalate may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin Salsalate may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine Mesalamine The therapeutic efficacy of Mesalazine can be decreased when used in combination with Salsalate.
Diclofenac Diclofenac The risk or severity of adverse effects can be increased when Diclofenac is combined with Salsalate.
Fluoxetine Fluoxetine The risk or severity of gastrointestinal bleeding can be increased when Fluoxetine is combined with Salsalate.
Nimodipine Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Salsalate.
Clozapine Clozapine Salsalate may decrease the excretion rate of Clozapine which could result in a higher serum level.
Estazolam Estazolam Salsalate may decrease the excretion rate of Estazolam which could result in a higher serum level.
Ofloxacin Ofloxacin Salsalate may increase the neuroexcitatory activities of Ofloxacin.
Didanosine Didanosine Salsalate may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Salsalate may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Benazepril.
Etodolac Etodolac The risk or severity of adverse effects can be increased when Etodolac is combined with Salsalate.
Felodipine Felodipine The therapeutic efficacy of Felodipine can be decreased when used in combination with Salsalate.
Fosinopril Fosinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Fosinopril.
Nabumetone Nabumetone The risk or severity of adverse effects can be increased when Nabumetone is combined with Salsalate.
Quinapril Quinapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Quinapril.
Ramipril Ramipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Ramipril.
Amlodipine Amlodipine Salsalate may decrease the antihypertensive activities of Amlodipine.
Itraconazole Itraconazole The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Salsalate.
Lisinopril Lisinopril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Lisinopril.
Oxaprozin Oxaprozin The risk or severity of adverse effects can be increased when Oxaprozin is combined with Salsalate.
Sotalol Sotalol Salsalate may decrease the antihypertensive activities of Sotalol.
Bisoprolol Bisoprolol Salsalate may decrease the antihypertensive activities of Bisoprolol.
Doxazosin Doxazosin The therapeutic efficacy of Doxazosin can be decreased when used in combination with Salsalate.
Terazosin Terazosin The therapeutic efficacy of Terazosin can be decreased when used in combination with Salsalate.
Isradipine Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Salsalate.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Salsalate.
Fluvoxamine Fluvoxamine The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of gastrointestinal bleeding can be increased when Salsalate is combined with Nefazodone.
Lamotrigine Lamotrigine Salsalate may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Losartan Losartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Losartan is combined with Salsalate.
Valacyclovir Valacyclovir Salsalate may decrease the excretion rate of Valaciclovir which could result in a higher serum level.
Tramadol Tramadol Salsalate may decrease the excretion rate of Tramadol which could result in a higher serum level.
Carboplatin Injection Carboplatin Injection Salsalate may decrease the excretion rate of Carboplatin which could result in a higher serum level.
Moexipril Moexipril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Moexipril.
Ifosfamide Injection Ifosfamide Injection Salsalate may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine The therapeutic efficacy of Nicardipine can be decreased when used in combination with Salsalate.
Bupropion Bupropion Salsalate may decrease the excretion rate of Bupropion which could result in a higher serum level.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Salsalate is combined with Ticlopidine.
Metformin Metformin Salsalate may decrease the excretion rate of Metformin which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Dalteparin.
Nisoldipine Nisoldipine The therapeutic efficacy of Nisoldipine can be decreased when used in combination with Salsalate.
Lamivudine Lamivudine Salsalate may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Acarbose Acarbose Salsalate may decrease the excretion rate of Acarbose which could result in a higher serum level.
Glimepiride Glimepiride The protein binding of Glimepiride can be decreased when combined with Salsalate.
Gemcitabine Injection Gemcitabine Injection Salsalate may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Salsalate may decrease the excretion rate of Cidofovir which could result in a higher serum level.
Meropenem Injection Meropenem Injection Salsalate may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine Clomipramine may decrease the excretion rate of Salsalate which could result in a higher serum level.
Fosfomycin Fosfomycin Salsalate may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Salsalate.
Trandolapril Trandolapril The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Salsalate is combined with Trandolapril.
Topiramate Topiramate Salsalate may decrease the excretion rate of Topiramate which could result in a higher serum level.
Valsartan Valsartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Valsartan is combined with Salsalate.
Pramipexole Pramipexole Salsalate may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Carvedilol Carvedilol Salsalate may decrease the antihypertensive activities of Carvedilol.
Nilutamide Nilutamide Salsalate may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Salsalate may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Salsalate.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Salsalate.
Propafenone Propafenone Salsalate may decrease the antihypertensive activities of Propafenone.
Irbesartan Irbesartan The risk or severity of renal failure, hyperkalemia, and hypertension can be increased when Irbesartan is combined with Salsalate.
Tamsulosin Tamsulosin Salsalate may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Finasteride Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Salsalate.
Quetiapine Quetiapine Salsalate may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Cefepime Injection Cefepime Injection The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Cefepime.
Cefprozil Cefprozil The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Salsalate.
Cefpodoxime Cefpodoxime The risk or severity of nephrotoxicity can be increased when Salsalate is combined with Cefpodoxime.
Cetirizine Cetirizine Salsalate may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Paroxetine Paroxetine The risk or severity of gastrointestinal bleeding can be increased when Paroxetine is combined with Salsalate.
Tolcapone Tolcapone Salsalate may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Citalopram Citalopram The risk or severity of gastrointestinal bleeding can be increased when Citalopram is combined with Salsalate.
Capecitabine Capecitabine Salsalate may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Abacavir Abacavir Salsalate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib The risk or severity of adverse effects can be increased when Celecoxib is combined with Salsalate.
Rosiglitazone Rosiglitazone Salsalate may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine Tolterodine Salsalate may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Oseltamivir Oseltamivir Salsalate may decrease the excretion rate of Oseltamivir which could result in a higher serum level.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Salsalate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Balsalazide can be decreased when used in combination with Salsalate.
Nateglinide Nateglinide Salsalate may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Rabeprazole Rabeprazole Salsalate may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists