Tolvaptan (low blood sodium)

Generic name: Pronounced as (tol vap' tan)
Brand names
  • Samsca®
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Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 08/15/2018

Tolvaptan (Samsca) may cause the level of sodium in your blood to increase too quickly. This may cause osmotic demyelination syndrome (ODS; serious nerve damage that may be caused by quick increases in sodium levels). Tell your doctor if you drink or have ever drunk large amounts of alcohol, if you have malnutrition (the body lacks the nutrients needed for good health), and if you have or have ever had liver disease or extremely low levels of sodium in your blood.

You and your doctor will take certain precautions to try to prevent ODS. You will begin your treatment with tolvaptan (Samsca) in the hospital so that your doctor can monitor you closely. If your doctor tells you to continue taking tolvaptan (Samsca) after you leave the hospital, you should not stop and re-start treatment on your own. You will need to return to the hospital when you restart the medication.

You will need to drink water whenever you are thirsty to help prevent ODS during your treatment with tolvaptan (Samsca) . Your doctor will not prescribe tolvaptan (Samsca) if you are unable to feel that you are thirsty. You should have drinking water available at all times during your treatment.

If you experience any of the following symptoms of ODS, tell your doctor immediately: difficulty speaking, difficulty swallowing, feeling that food or drinks are getting stuck in your throat, drowsiness, confusion, mood changes, body movements that are difficult to control, weakness of the arms or legs, or seizures.

You should know that tolvaptan is also available as a tablet (Jynarque) to slow the worsening of kidney function in adults with a certain type of inherited kidney disease. If you have this kidney disease, you should not take tolvaptan (Samsca). Because of the risk of liver problems with tolvaptan, Jynarque is available only through a special restricted distribution program. This monograph only gives information about tolvaptan tablets (Samsca) to treat low levels of sodium in the blood. If you are using this medication to slow the worsening of your kidney function, read the monograph entitled tolvaptan (kidney disease).

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with tolvaptan and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risk of taking tolvaptan (Samsca).

Tolvaptan (Samsca) is used to treat hyponatremia (low levels of sodium in the blood) in people who have heart failure (condition in which the heart cannot pump enough blood to all parts of the body), syndrome of inappropriate antidiuretic hormone (SIADH; condition in which the body produces too much of a certain natural substance that causes the body to retain water) or other conditions. Tolvaptan is in a class of medications called vasopressin V2 receptor antagonists. It works by increasing the amount of water released from the body as urine. Removing fluid from the body helps to increase the level of sodium in the blood.

Tolvaptan (Samsca) comes as a tablet to take by mouth. It is usually taken once a day with or without food for no longer than 30 days. At the beginning of your treatment, you will be given tolvaptan (Samsca) at a regularly scheduled time in the hospital. If you are told to take tolvaptan (Samsca) at home after you are discharged, you should take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tolvaptan (Samsca) exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of tolvaptan (Samsca) and gradually increase your dose, not more often than once every 24 hours.

Talk to your doctor about what you should do after you stop taking tolvaptan (Samsca). You will probably need to limit the amount of fluid you drink, and your doctor will monitor you carefully during this time.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking tolvaptan (Samsca),

  • tell your doctor and pharmacist if you are allergic to tolvaptan (Samsca, Jynarque) , any other medications, or any of the ingredients in tolvaptan tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor if you are taking certain antifungals such as ketoconazole (Nizoral) or itraconazole (Sporanox); clarithromycin (Biaxin); certain medications for HIV such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), or saquinavir (Invirase); desmopressin (dDAVP, Stimate); nefazodone; or telithromycin (Ketek). Your doctor may tell you not to take tolvaptan (Samsca) if you are taking one or more of these medications.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (Prinivil, Zestril, in Zestoretic), moexipril, perindopril, (quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Tarka); angiotensin II receptor blockers such as candesartan (Atacand), eprosartan, irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Twynsta), and valsartan (Diovan, Prexxartan, in Entresto, in Exforge); aprepitant (Emend); barbiturates such as phenobarbital; carbamazepine (Carbatrol, Equetro, Tegretol); cyclosporine (Gengraf, Neoral, Sandimmune); desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin); diltiazem (Cardizem, Diltzac, Tiazac); diuretics (water pills); erythromycin (E.E.S., ERYC, Erythrocin, PCE); fluconazole (Diflucan); phenytoin (Dilantin); potassium supplements; rifabutin (Mycobutin); rifampin (Rimactane, Rifadin, in Rifater, in Rifamate); rifapentine (Priftin); and verapamil (Calan, Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with tolvaptan (Samsca), so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor what herbal products you are taking or plan to take, especially St John's wort.

  • tell your doctor if you have kidney disease and do not produce urine, if you have severe vomiting or diarrhea, or if you have lost a lot of fluid from your body and feel dizzy or faint. Your doctor will probably tell you not to take tolvaptan (Samsca). Your doctor will also probably not prescribe tolvaptan (Samsca) if your sodium level must be increased very quickly.

  • tell your doctor if you have or have ever had a high level of potassium in your blood.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking tolvaptan (Samsca), call your doctor.

Do not eat grapefruit or drink grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Tolvaptan (Samsca) may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • thirst

    • dry mouth

    • frequent, excessive urination

    • constipation

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • loss of appetite

    • nausea

    • vomiting

    • fever

    • feeling unwell

    • unusual tiredness or weakness

    • itching

    • yellowing of the skin or eyes

    • dark urine

    • pain in the upper right part of the stomach

    • diarrhea

    • inability to drink normally

    • dizziness

    • faintness

    • vomit that is bloody or looks like coffee grounds

    • bloody or black and tarry stools

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

    • hives

    • rash

  • Tolvaptan (Samsca) may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • excessive urination

  • excessive thirst

  • dizziness

  • faintness

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to tolvaptan (Samsca).

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Delavirdine Delavirdine The metabolism of Tolvaptan can be decreased when combined with Delavirdine.
Bisacodyl Bisacodyl The risk or severity of adverse effects can be increased when Tolvaptan is combined with Bisacodyl.
Candesartan Candesartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Candesartan.
Cilostazol Cilostazol Tolvaptan may increase the excretion rate of Cilostazol which could result in a lower serum level and potentially a reduction in efficacy.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Diphenoxylate.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The serum concentration of Tolvaptan can be increased when it is combined with Erythromycin.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Tolvaptan may increase the excretion rate of Conjugated estrogens which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Tolvaptan.
Guanfacine Guanfacine Tolvaptan may increase the excretion rate of Guanfacine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Hydroxide Magnesium Hydroxide The risk or severity of adverse effects can be increased when Tolvaptan is combined with Magnesium hydroxide.
Magnesium Oxide Magnesium Oxide The risk or severity of adverse effects can be increased when Tolvaptan is combined with Magnesium oxide.
Methylergonovine Methylergonovine The metabolism of Tolvaptan can be decreased when combined with Methylergometrine.
Mycophenolate Mycophenolate Tolvaptan may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.
Olsalazine Olsalazine The risk or severity of hyperkalemia can be increased when Olsalazine is combined with Tolvaptan.
Paregoric Paregoric The serum concentration of Tolvaptan can be increased when it is combined with Morphine.
Penbutolol Penbutolol The risk or severity of hyperkalemia can be increased when Acebutolol is combined with Tolvaptan.
Pentazocine Pentazocine The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Tolvaptan is combined with Polyethylene glycol.
Potassium Potassium Potassium cation may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Tolvaptan may increase the excretion rate of Prednisone which could result in a lower serum level and potentially a reduction in efficacy.
Psyllium Psyllium The risk or severity of adverse effects can be increased when Tolvaptan is combined with Plantago seed.
Ranitidine Ranitidine Tolvaptan may increase the excretion rate of Ranitidine which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine Reserpine The serum concentration of Tolvaptan can be increased when it is combined with Reserpine.
Rizatriptan Rizatriptan Tolvaptan may increase the excretion rate of Rizatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan Sumatriptan Tolvaptan may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tacrolimus Tacrolimus The serum concentration of Tolvaptan can be increased when it is combined with Tacrolimus.
Triamcinolone Triamcinolone The metabolism of Tolvaptan can be increased when combined with Triamcinolone.
Ampicillin Injection Ampicillin Injection Tolvaptan may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection Doxycycline Injection The metabolism of Doxycycline can be decreased when combined with Tolvaptan.
Fluconazole Injection Fluconazole Injection The serum concentration of Tolvaptan can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Hydromorphone.
Levofloxacin Injection Levofloxacin Injection Tolvaptan may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be increased when combined with Tolvaptan.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Tolvaptan can be increased when combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection Tolvaptan may increase the excretion rate of Metoclopramide which could result in a lower serum level and potentially a reduction in efficacy.
Metronidazole Injection Metronidazole Injection The metabolism of Tolvaptan can be decreased when combined with Metronidazole.
Morphine Injection Morphine Injection The serum concentration of Tolvaptan can be increased when it is combined with Morphine.
Vancomycin Injection Vancomycin Injection Tolvaptan may increase the excretion rate of Vancomycin which could result in a lower serum level and potentially a reduction in efficacy.
Altretamine Altretamine Tolvaptan may increase the excretion rate of Amphetamine which could result in a lower serum level and potentially a reduction in efficacy.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Tolvaptan.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Enoxaparin is combined with Tolvaptan.
Eprosartan Eprosartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Eprosartan.
Meloxicam Meloxicam The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Meloxicam.
Orlistat Orlistat The metabolism of Tolvaptan can be increased when combined with Orlistat.
Oxcarbazepine Oxcarbazepine The metabolism of Tolvaptan can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole Tolvaptan may increase the excretion rate of Pantoprazole which could result in a lower serum level and potentially a reduction in efficacy.
Telmisartan Telmisartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Telmisartan.
Temozolomide Temozolomide Tolvaptan may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon Zaleplon Tolvaptan may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Anakinra Anakinra The metabolism of Tolvaptan can be increased when combined with Anakinra.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Tolvaptan.
Etanercept Injection Etanercept Injection The metabolism of Tolvaptan can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Tolvaptan can be increased when combined with Modafinil.
Perindopril Perindopril Tolvaptan may increase the hyperkalemic activities of Perindopril.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Tolvaptan.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hyperkalemia can be increased when Choline magnesium trisalicylate is combined with Tolvaptan.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Tolvaptan.
Epinephrine Injection Epinephrine Injection The metabolism of Tolvaptan can be decreased when combined with Epinephrine.
Eplerenone Eplerenone The risk or severity of hyperkalemia can be increased when Eplerenone is combined with Tolvaptan.
Olmesartan Olmesartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Olmesartan.
Zonisamide Zonisamide The serum concentration of Tolvaptan can be increased when it is combined with Zonisamide.
Adalimumab Injection Adalimumab Injection The metabolism of Tolvaptan can be increased when combined with Adalimumab.
Atomoxetine Atomoxetine Tolvaptan may increase the excretion rate of Atomoxetine which could result in a lower serum level and potentially a reduction in efficacy.
Atazanavir Atazanavir The metabolism of Tolvaptan can be decreased when combined with Atazanavir.
Almotriptan Almotriptan Tolvaptan may increase the excretion rate of Almotriptan which could result in a lower serum level and potentially a reduction in efficacy.
Mefloquine Mefloquine The metabolism of Tolvaptan can be decreased when combined with Mefloquine.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Tolvaptan is combined with Polyethylene glycol.
Rosuvastatin Rosuvastatin The metabolism of Tolvaptan can be decreased when combined with Rosuvastatin.
Vardenafil Vardenafil The serum concentration of Tolvaptan can be increased when it is combined with Vardenafil.
Aprepitant Aprepitant The metabolism of Tolvaptan can be decreased when combined with Aprepitant.
Emtricitabine Emtricitabine Tolvaptan may increase the excretion rate of Emtricitabine which could result in a lower serum level and potentially a reduction in efficacy.
Memantine Memantine Tolvaptan may increase the excretion rate of Memantine which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod Tegaserod The serum concentration of Tolvaptan can be increased when it is combined with Tegaserod.
Tadalafil Tadalafil Tolvaptan may increase the excretion rate of Tadalafil which could result in a lower serum level and potentially a reduction in efficacy.
Progesterone Progesterone The metabolism of Tolvaptan can be increased when combined with Progesterone.
Infliximab Injection Infliximab Injection The metabolism of Tolvaptan can be increased when combined with Infliximab.
Rifaximin Rifaximin The metabolism of Tolvaptan can be increased when combined with Rifaximin.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Tolvaptan.
Norethindrone Norethindrone The metabolism of Tolvaptan can be decreased when combined with Norethisterone.
Tinidazole Tinidazole Tolvaptan may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Bosentan Bosentan The metabolism of Tolvaptan can be increased when combined with Bosentan.
Cefditoren Cefditoren Tolvaptan may increase the excretion rate of Cefdinir which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection Cyanocobalamin Injection Tolvaptan may increase the excretion rate of Hydroxocobalamin which could result in a lower serum level and potentially a reduction in efficacy.
Erlotinib Erlotinib The metabolism of Tolvaptan can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Tolvaptan may increase the excretion rate of Eszopiclone which could result in a lower serum level and potentially a reduction in efficacy.
Ganciclovir Ganciclovir Tolvaptan may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Ribavirin Ribavirin Tolvaptan may increase the excretion rate of Ribavirin which could result in a lower serum level and potentially a reduction in efficacy.
Valganciclovir Valganciclovir Tolvaptan may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Voriconazole Voriconazole The metabolism of Tolvaptan can be decreased when combined with Voriconazole.
Dextroamphetamine Dextroamphetamine Tolvaptan may increase the excretion rate of Amphetamine which could result in a lower serum level and potentially a reduction in efficacy.
Ramelteon Ramelteon Tolvaptan may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Fentanyl Fentanyl Tolvaptan may increase the excretion rate of Fentanyl which could result in a lower serum level and potentially a reduction in efficacy.
Pregabalin Pregabalin Tolvaptan may increase the excretion rate of Pregabalin which could result in a lower serum level and potentially a reduction in efficacy.
Deferasirox Deferasirox The metabolism of Tolvaptan can be increased when combined with Deferasirox.
Tipranavir Tipranavir The serum concentration of Tolvaptan can be decreased when it is combined with Tipranavir.
Felbamate Felbamate The metabolism of Tolvaptan can be increased when combined with Felbamate.
Ranolazine Ranolazine The serum concentration of Tolvaptan can be increased when it is combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Tolvaptan can be increased when combined with Abatacept.
Rasagiline Rasagiline Tolvaptan may increase the excretion rate of Rasagiline which could result in a lower serum level and potentially a reduction in efficacy.
Imatinib Imatinib The metabolism of Tolvaptan can be decreased when combined with Imatinib.
Sitagliptin Sitagliptin The serum concentration of Tolvaptan can be increased when it is combined with Sitagliptin.
Varenicline Varenicline Tolvaptan may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Gefitinib Gefitinib The metabolism of Tolvaptan can be decreased when combined with Gefitinib.
Albuterol Albuterol Tolvaptan may increase the excretion rate of Salbutamol which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone Paliperidone The serum concentration of Tolvaptan can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Tolvaptan.
Clofarabine Injection Clofarabine Injection Tolvaptan may increase the excretion rate of Clofarabine which could result in a lower serum level and potentially a reduction in efficacy.
Lubiprostone Lubiprostone The risk or severity of adverse effects can be increased when Tolvaptan is combined with Lubiprostone.
Posaconazole Posaconazole The metabolism of Tolvaptan can be decreased when combined with Posaconazole.
Primaquine Primaquine The metabolism of Tolvaptan can be decreased when combined with Primaquine.
Aliskiren Aliskiren The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Aliskiren.
Darunavir Darunavir The serum concentration of Tolvaptan can be increased when it is combined with Darunavir.
Pemetrexed Injection Pemetrexed Injection Tolvaptan may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Sorafenib Sorafenib The serum concentration of Tolvaptan can be increased when it is combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Tolvaptan can be decreased when combined with Sunitinib.
Lapatinib Lapatinib The serum concentration of Tolvaptan can be increased when it is combined with Lapatinib.
Levocetirizine Levocetirizine Tolvaptan may increase the excretion rate of Levocetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Pegaptanib Injection Pegaptanib Injection Tolvaptan may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Dasatinib Dasatinib The metabolism of Tolvaptan can be decreased when combined with Dasatinib.
Armodafinil Armodafinil The metabolism of Tolvaptan can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection Tolvaptan may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Ivermectin Ivermectin The metabolism of Tolvaptan can be increased when combined with Ivermectin.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Tolvaptan is combined with Castor oil.
Temsirolimus Temsirolimus The serum concentration of Tolvaptan can be increased when it is combined with Temsirolimus.
Lenalidomide Lenalidomide Tolvaptan may increase the excretion rate of Lenalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Nilotinib Nilotinib The serum concentration of Tolvaptan can be increased when it is combined with Nilotinib.
Toremifene Toremifene The serum concentration of Tolvaptan can be increased when it is combined with Toremifene.
Bexarotene Bexarotene The metabolism of Tolvaptan can be increased when combined with Bexarotene.
Budesonide Budesonide The metabolism of Budesonide can be increased when combined with Tolvaptan.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Tolvaptan can be decreased when combined with Chloramphenicol.
Desmopressin Desmopressin The therapeutic efficacy of Desmopressin can be decreased when used in combination with Tolvaptan.
Doripenem Injection Doripenem Injection Tolvaptan may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Etravirine Etravirine The serum concentration of Tolvaptan can be decreased when it is combined with Etravirine.
Arsenic Trioxide Injection Arsenic Trioxide Injection Tolvaptan may increase the excretion rate of Arsenic trioxide which could result in a lower serum level and potentially a reduction in efficacy.
Mitoxantrone Injection Mitoxantrone Injection The metabolism of Tolvaptan can be decreased when combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The metabolism of Desvenlafaxine can be decreased when combined with Tolvaptan.
Cevimeline Cevimeline Tolvaptan may increase the excretion rate of Cevimeline which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol Nebivolol The risk or severity of hyperkalemia can be increased when Nebivolol is combined with Tolvaptan.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Tolvaptan.
Pilocarpine Pilocarpine The metabolism of Tolvaptan can be decreased when combined with Pilocarpine.
Certolizumab Injection Certolizumab Injection The metabolism of Certolizumab pegol can be increased when combined with Tolvaptan.
Daptomycin Injection Daptomycin Injection Tolvaptan may increase the excretion rate of Daptomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mitotane Mitotane The metabolism of Tolvaptan can be increased when combined with Mitotane.
Methylnaltrexone Injection Methylnaltrexone Injection Tolvaptan may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Rufinamide Rufinamide The metabolism of Tolvaptan can be increased when combined with Rufinamide.
Silodosin Silodosin The serum concentration of Tolvaptan can be increased when it is combined with Silodosin.
Midazolam Midazolam The metabolism of Midazolam can be decreased when combined with Tolvaptan.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Tolvaptan may increase the excretion rate of Dexrazoxane which could result in a lower serum level and potentially a reduction in efficacy.
Milnacipran Milnacipran The metabolism of Milnacipran can be decreased when combined with Tolvaptan.
Plerixafor Injection Plerixafor Injection Tolvaptan may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate Sodium Phosphate Tolvaptan may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Tolvaptan may increase the excretion rate of Fesoterodine which could result in a lower serum level and potentially a reduction in efficacy.
Betaxolol Betaxolol The risk or severity of hyperkalemia can be increased when Betaxolol is combined with Tolvaptan.
Prasugrel Prasugrel Tolvaptan may increase the excretion rate of Prasugrel which could result in a lower serum level and potentially a reduction in efficacy.
Lacosamide Lacosamide The metabolism of Tolvaptan can be decreased when combined with Lacosamide.
Everolimus Everolimus The serum concentration of Tolvaptan can be increased when it is combined with Everolimus.
Dronedarone Dronedarone The serum concentration of Tolvaptan can be increased when it is combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection Tolvaptan may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection Palonosetron Injection Tolvaptan may increase the excretion rate of Palonosetron which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin Saxagliptin Tolvaptan may increase the excretion rate of Saxagliptin which could result in a lower serum level and potentially a reduction in efficacy.
Telavancin Injection Telavancin Injection Tolvaptan may increase the excretion rate of Telavancin which could result in a lower serum level and potentially a reduction in efficacy.
Romidepsin Injection Romidepsin Injection The serum concentration of Tolvaptan can be increased when it is combined with Romidepsin.
Tapentadol Tapentadol The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Tapentadol.
Topotecan Topotecan The metabolism of Topotecan can be increased when combined with Tolvaptan.
Golimumab Injection Golimumab Injection The metabolism of Tolvaptan can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Tolvaptan.
Albendazole Albendazole The metabolism of Tolvaptan can be decreased when combined with Albendazole.
Oxymorphone Oxymorphone The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Oxymorphone.
Tocilizumab Injection Tocilizumab Injection The metabolism of Tolvaptan can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Tolvaptan may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Tolvaptan can be increased when it is combined with Cabazitaxel.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Tolvaptan.
Ipilimumab Injection Ipilimumab Injection Tolvaptan may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection Denileukin Diftitox Injection The metabolism of Aldesleukin can be decreased when combined with Tolvaptan.
Terbutaline Injection Terbutaline Injection Tolvaptan may increase the excretion rate of Terbutaline which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan Azilsartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Azilsartan medoxomil.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Tolvaptan.
Linagliptin Linagliptin The serum concentration of Tolvaptan can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Tolvaptan can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Tolvaptan can be increased when it is combined with Glecaprevir.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Tolvaptan.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Tolvaptan can be increased when combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban The serum concentration of Rivaroxaban can be increased when it is combined with Tolvaptan.
Ticagrelor Ticagrelor The serum concentration of Tolvaptan can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Tolvaptan.
Ruxolitinib Ruxolitinib Tolvaptan may increase the excretion rate of Ruxolitinib which could result in a lower serum level and potentially a reduction in efficacy.
Vandetanib Vandetanib The serum concentration of Tolvaptan can be increased when it is combined with Vandetanib.
Clobazam Clobazam The metabolism of Tolvaptan can be increased when combined with Clobazam.
Vemurafenib Vemurafenib The serum concentration of Tolvaptan can be increased when it is combined with Vemurafenib.
Ivacaftor Ivacaftor The serum concentration of Tolvaptan can be increased when it is combined with Ivacaftor.
Deferiprone Deferiprone Tolvaptan may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Tolvaptan.
Crizotinib Crizotinib The metabolism of Tolvaptan can be decreased when combined with Crizotinib.
Cabergoline Cabergoline The metabolism of Tolvaptan can be decreased when combined with Cabergoline.
Naloxone Injection Naloxone Injection The metabolism of Naloxone can be decreased when combined with Tolvaptan.
Ambrisentan Ambrisentan The serum concentration of Tolvaptan can be increased when it is combined with Ambrisentan.
Fondaparinux Injection Fondaparinux Injection Tolvaptan may increase the excretion rate of Fondaparinux which could result in a lower serum level and potentially a reduction in efficacy.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Tolvaptan.
Enzalutamide Enzalutamide The serum concentration of Tolvaptan can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Tolvaptan can be increased when it is combined with Mirabegron.
Regorafenib Regorafenib The serum concentration of Tolvaptan can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Tolvaptan.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Tolvaptan can be increased when combined with Corticotropin.
Linaclotide Linaclotide The risk or severity of adverse effects can be increased when Tolvaptan is combined with Linaclotide.
Teduglutide Injection Teduglutide Injection Tolvaptan may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Alogliptin Alogliptin Tolvaptan may increase the excretion rate of Alogliptin which could result in a lower serum level and potentially a reduction in efficacy.
Ponatinib Ponatinib The serum concentration of Tolvaptan can be increased when it is combined with Ponatinib.
Pomalidomide Pomalidomide The serum concentration of Tolvaptan can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Tolvaptan can be decreased when combined with Trastuzumab emtansine.
Apixaban Apixaban The serum concentration of Tolvaptan can be increased when it is combined with Apixaban.
Canagliflozin Canagliflozin The serum concentration of Tolvaptan can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be increased when combined with Tolvaptan.
Trametinib Trametinib The metabolism of Trametinib can be increased when combined with Tolvaptan.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Tolvaptan.
Afatinib Afatinib The serum concentration of Tolvaptan can be increased when it is combined with Afatinib.
Levomilnacipran Levomilnacipran Tolvaptan may increase the excretion rate of Levomilnacipran which could result in a lower serum level and potentially a reduction in efficacy.
Ertapenem Injection Ertapenem Injection Tolvaptan may increase the excretion rate of Ertapenem which could result in a lower serum level and potentially a reduction in efficacy.
Vortioxetine Vortioxetine Tolvaptan may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Perampanel Perampanel The metabolism of Tolvaptan can be increased when combined with Perampanel.
Lomitapide Lomitapide The serum concentration of Tolvaptan can be increased when it is combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The risk or severity of hyperkalemia can be increased when Ketorolac is combined with Tolvaptan.
Simeprevir Simeprevir The serum concentration of Tolvaptan can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Tolvaptan.
Apremilast Apremilast The metabolism of Apremilast can be increased when combined with Tolvaptan.
Droxidopa Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Tolvaptan.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Tolvaptan.
Siltuximab Injection Siltuximab Injection The metabolism of Tolvaptan can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Tolvaptan can be increased when combined with Eslicarbazepine.
Belinostat Injection Belinostat Injection The serum concentration of Tolvaptan can be increased when it is combined with Belinostat.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Tolvaptan.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Tolvaptan.
Oritavancin Injection Oritavancin Injection The metabolism of Tolvaptan can be increased when combined with Oritavancin.
Empagliflozin Empagliflozin Empagliflozin may increase the diuretic activities of Tolvaptan.
Vorapaxar Vorapaxar The serum concentration of Tolvaptan can be increased when it is combined with Vorapaxar.
Hydrocodone Hydrocodone The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Hydrocodone.
Suvorexant Suvorexant The serum concentration of Tolvaptan can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Tolvaptan.
Olaparib Olaparib The metabolism of Tolvaptan can be decreased when combined with Olaparib.
Methamphetamine Methamphetamine Tolvaptan may increase the excretion rate of Metamfetamine which could result in a lower serum level and potentially a reduction in efficacy.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Tolvaptan.
Lanreotide Injection Lanreotide Injection The metabolism of Tolvaptan can be decreased when combined with Lanreotide.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Tolvaptan.
Secukinumab Injection Secukinumab Injection The metabolism of Tolvaptan can be increased when combined with Secukinumab.
Palbociclib Palbociclib The serum concentration of Tolvaptan can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Tolvaptan.
Panobinostat Panobinostat The serum concentration of Tolvaptan can be increased when it is combined with Panobinostat.
Haloperidol Injection Haloperidol Injection The serum concentration of Tolvaptan can be increased when it is combined with Haloperidol.
Amiloride Amiloride The risk or severity of hyperkalemia can be increased when Amiloride is combined with Tolvaptan.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Tolvaptan can be increased when it is combined with Isavuconazonium.
Macitentan Macitentan Tolvaptan may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin Flibanserin The serum concentration of Tolvaptan can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Tolvaptan can be increased when it is combined with Rolapitant.
Prednisolone Prednisolone The metabolism of Tolvaptan can be increased when combined with Prednisolone.
Daclatasvir Daclatasvir The serum concentration of Tolvaptan can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Tolvaptan can be decreased when combined with Ziprasidone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Tolvaptan may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline Eluxadoline The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Eluxadoline.
Cobimetinib Cobimetinib The metabolism of Tolvaptan can be decreased when combined with Cobimetinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Tolvaptan.
Ixazomib Ixazomib Tolvaptan may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Rifapentine Rifapentine The metabolism of Tolvaptan can be increased when combined with Rifapentine.
Lesinurad Lesinurad The metabolism of Lesinurad can be increased when combined with Tolvaptan.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The metabolism of Tolvaptan can be decreased when combined with Amphotericin B.
Dexamethasone Injection Dexamethasone Injection The metabolism of Tolvaptan can be increased when combined with Dexamethasone.
Brivaracetam Injection Brivaracetam Injection Tolvaptan may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Venetoclax Venetoclax The serum concentration of Tolvaptan can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Tolvaptan can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Tolvaptan can be increased when it is combined with Selexipag.
Furosemide Injection Furosemide Injection Tolvaptan may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Rucaparib Rucaparib The serum concentration of Tolvaptan can be increased when it is combined with Rucaparib.
Lixisenatide Injection Lixisenatide Injection Tolvaptan may increase the excretion rate of Lixisenatide which could result in a lower serum level and potentially a reduction in efficacy.
Ribociclib Ribociclib The metabolism of Tolvaptan can be decreased when combined with Ribociclib.
Brigatinib Brigatinib The metabolism of Tolvaptan can be increased when combined with Brigatinib.
Doxepin (Insomnia) Doxepin (Insomnia) Tolvaptan may increase the excretion rate of Doxepin which could result in a lower serum level and potentially a reduction in efficacy.
Plecanatide Plecanatide The risk or severity of adverse effects can be increased when Tolvaptan is combined with Plecanatide.
Deutetrabenazine Deutetrabenazine Tolvaptan may increase the excretion rate of Deutetrabenazine which could result in a lower serum level and potentially a reduction in efficacy.
Valbenazine Valbenazine Tolvaptan may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort Deflazacort The metabolism of Tolvaptan can be increased when combined with Deflazacort.
Naldemedine Naldemedine Tolvaptan may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Sarilumab Injection Sarilumab Injection The metabolism of Tolvaptan can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Tolvaptan can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Tolvaptan can be increased when it is combined with Neratinib.
Enasidenib Enasidenib The serum concentration of Tolvaptan can be increased when it is combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Tolvaptan can be increased when it is combined with Inotuzumab ozogamicin.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Tolvaptan can be increased when combined with Fosaprepitant.
Benznidazole Benznidazole Tolvaptan may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Copanlisib Injection Copanlisib Injection The serum concentration of Tolvaptan can be increased when it is combined with Copanlisib.
Delafloxacin Delafloxacin Tolvaptan may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Tolvaptan.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Tolvaptan.
Acalabrutinib Acalabrutinib The metabolism of Tolvaptan can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Tolvaptan can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Tolvaptan.
Buprenorphine Injection Buprenorphine Injection The metabolism of Tolvaptan can be decreased when combined with Buprenorphine.
Apalutamide Apalutamide The serum concentration of Tolvaptan can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Tolvaptan can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Tolvaptan.
Baricitinib Baricitinib The serum concentration of Tolvaptan can be increased when it is combined with Baricitinib.
Lofexidine Lofexidine Tolvaptan may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Plazomicin Injection Plazomicin Injection Tolvaptan may increase the excretion rate of Plazomicin which could result in a lower serum level and potentially a reduction in efficacy.
Eliglustat Eliglustat The serum concentration of Eliglustat can be increased when it is combined with Tolvaptan.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Tolvaptan.
Ivosidenib Ivosidenib The serum concentration of Tolvaptan can be increased when it is combined with Ivosidenib.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Tolvaptan.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Tolvaptan.
Dacomitinib Dacomitinib The serum concentration of Tolvaptan can be increased when it is combined with Dacomitinib.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Tolvaptan.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Tolvaptan.
Sarecycline Sarecycline The serum concentration of Tolvaptan can be increased when it is combined with Sarecycline.
Stiripentol Stiripentol The metabolism of Stiripentol can be decreased when combined with Tolvaptan.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Tolvaptan.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Tolvaptan.
Glasdegib Glasdegib The serum concentration of Tolvaptan can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Tolvaptan can be increased when it is combined with Larotrectinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Tolvaptan can be increased when combined with Paclitaxel.
Rifamycin Rifamycin The serum concentration of Tolvaptan can be increased when it is combined with Rifamycin.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Tolvaptan.
Magnesium Citrate Magnesium Citrate The risk or severity of adverse effects can be increased when Tolvaptan is combined with Magnesium citrate.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Tolvaptan can be increased when combined with Emapalumab.
Siponimod Siponimod The metabolism of Tolvaptan can be decreased when combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Tolvaptan may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.
Erdafitinib Erdafitinib The serum concentration of Tolvaptan can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Tolvaptan can be increased when combined with Alpelisib.
Solriamfetol Solriamfetol Tolvaptan may increase the excretion rate of Solriamfetol which could result in a lower serum level and potentially a reduction in efficacy.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Tolvaptan.
Triclabendazole Triclabendazole The metabolism of Tolvaptan can be decreased when combined with Triclabendazole.
Entrectinib Entrectinib The serum concentration of Tolvaptan can be increased when it is combined with Entrectinib.
Istradefylline Istradefylline The serum concentration of Tolvaptan can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Tolvaptan can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Tolvaptan.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Tolvaptan.
Phenytoin Injection Phenytoin Injection The metabolism of Tolvaptan can be increased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Tolvaptan can be increased when combined with Fosphenytoin.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Tolvaptan.
Voxelotor Voxelotor The serum concentration of Tolvaptan can be increased when it is combined with Voxelotor.
Lasmiditan Lasmiditan The serum concentration of Tolvaptan can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Tolvaptan.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Tolvaptan.
Cenobamate Cenobamate The serum concentration of Tolvaptan can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Tolvaptan.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Tolvaptan.
Tucatinib Tucatinib Tolvaptan may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Tolvaptan.
Ripretinib Ripretinib The serum concentration of Tolvaptan can be increased when it is combined with Ripretinib.
Capmatinib Capmatinib The serum concentration of Tolvaptan can be increased when it is combined with Capmatinib.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Tolvaptan.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Tolvaptan.
Octreotide Octreotide The serum concentration of Tolvaptan can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Tolvaptan can be increased when it is combined with Belantamab mafodotin.
Pralsetinib Pralsetinib The serum concentration of Tolvaptan can be increased when it is combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Tolvaptan can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Tolvaptan can be decreased when combined with Drospirenone.
Viloxazine Viloxazine Tolvaptan may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) The metabolism of Tolvaptan can be increased when combined with Vitamin E.
Fenoprofen Fenoprofen The risk or severity of hyperkalemia can be increased when Fenoprofen is combined with Tolvaptan.
Indomethacin Indomethacin The risk or severity of hyperkalemia can be increased when Indomethacin is combined with Tolvaptan.
Mefenamic Acid Mefenamic Acid The risk or severity of hyperkalemia can be increased when Mefenamic acid is combined with Tolvaptan.
Naproxen Naproxen The risk or severity of hyperkalemia can be increased when Naproxen is combined with Tolvaptan.
Tolmetin Tolmetin The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Tolvaptan.
Sulindac Sulindac The risk or severity of hyperkalemia can be increased when Sulindac is combined with Tolvaptan.
Trazodone Trazodone The serum concentration of Tolvaptan can be decreased when it is combined with Trazodone.
Isotretinoin Isotretinoin Tolvaptan may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy.
Sucralfate Sucralfate Tolvaptan may increase the excretion rate of Sucralfate which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine Floxuridine Tolvaptan may increase the excretion rate of Floxuridine which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital Phenobarbital The metabolism of Tolvaptan can be increased when combined with Phenobarbital.
Metaxalone Metaxalone Tolvaptan may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection Methotrexate Injection Tolvaptan may increase the excretion rate of Methotrexate which could result in a lower serum level and potentially a reduction in efficacy.
Levorphanol Levorphanol The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Levorphanol.
Primidone Primidone The metabolism of Tolvaptan can be increased when combined with Primidone.
Methsuximide Methsuximide The risk or severity of hyperkalemia can be increased when Methsuximide is combined with Tolvaptan.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Tolvaptan.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Tolvaptan.
Oxazepam Oxazepam Tolvaptan may increase the excretion rate of Oxazepam which could result in a lower serum level and potentially a reduction in efficacy.
Flurazepam Flurazepam Tolvaptan may increase the excretion rate of Flurazepam which could result in a lower serum level and potentially a reduction in efficacy.
Clorazepate Clorazepate Tolvaptan may increase the excretion rate of Clorazepic acid which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Tolvaptan.
Carmustine Carmustine Tolvaptan may increase the excretion rate of Carmustine which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine Amantadine Tolvaptan may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine Codeine Tolvaptan may increase the excretion rate of Codeine which could result in a lower serum level and potentially a reduction in efficacy.
Bromocriptine Bromocriptine The metabolism of Tolvaptan can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Tolvaptan can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine The metabolism of Phenelzine can be decreased when combined with Tolvaptan.
Tetracycline Tetracycline The metabolism of Tetracycline can be decreased when combined with Tolvaptan.
Prochlorperazine Prochlorperazine The metabolism of Tolvaptan can be decreased when combined with Prochlorperazine.
Bleomycin Bleomycin Tolvaptan may increase the excretion rate of Bleomycin which could result in a lower serum level and potentially a reduction in efficacy.
Sulfadiazine Sulfadiazine Tolvaptan may increase the excretion rate of Sulfadiazine which could result in a lower serum level and potentially a reduction in efficacy.
Oxycodone Oxycodone The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Oxycodone.
Methadone Methadone The metabolism of Methadone can be increased when combined with Tolvaptan.
Oxybutynin Oxybutynin The metabolism of Tolvaptan can be decreased when combined with Oxybutynin.
Benztropine Benztropine Tolvaptan may increase the excretion rate of Benzatropine which could result in a lower serum level and potentially a reduction in efficacy.
Maprotiline Maprotiline Tolvaptan may increase the excretion rate of Maprotiline which could result in a lower serum level and potentially a reduction in efficacy.
Ibuprofen Ibuprofen Tolvaptan may increase the excretion rate of Ibuprofen which could result in a lower serum level and potentially a reduction in efficacy.
Orphenadrine Orphenadrine The metabolism of Tolvaptan can be decreased when combined with Orphenadrine.
Azathioprine Azathioprine Tolvaptan may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Phentermine Phentermine The metabolism of Tolvaptan can be decreased when combined with Phentermine.
Methylphenidate Methylphenidate Tolvaptan may increase the excretion rate of Methylphenidate which could result in a lower serum level and potentially a reduction in efficacy.
Sulfasalazine Sulfasalazine The risk or severity of hyperkalemia can be increased when Sulfasalazine is combined with Tolvaptan.
Hydrocortisone Hydrocortisone The metabolism of Tolvaptan can be increased when combined with Hydrocortisone.
Doxorubicin Doxorubicin The metabolism of Tolvaptan can be decreased when combined with Doxorubicin.
Dactinomycin Dactinomycin The serum concentration of Tolvaptan can be increased when it is combined with Dactinomycin.
Phenazopyridine Phenazopyridine Tolvaptan may increase the excretion rate of Phenazopyridine which could result in a lower serum level and potentially a reduction in efficacy.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Tolvaptan.
Methyldopa Methyldopa Tolvaptan may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Hydralazine Hydralazine The metabolism of Hydralazine can be decreased when combined with Tolvaptan.
Cimetidine Cimetidine The metabolism of Cimetidine can be decreased when combined with Tolvaptan.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Tolvaptan.
Clonazepam Clonazepam Tolvaptan may increase the excretion rate of Clonazepam which could result in a lower serum level and potentially a reduction in efficacy.
Loperamide Loperamide The metabolism of Tolvaptan can be decreased when combined with Loperamide.
Promethazine Promethazine Tolvaptan may increase the excretion rate of Promethazine which could result in a lower serum level and potentially a reduction in efficacy.
Meclofenamate Meclofenamate Meclofenamic acid may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Daunorubicin Daunorubicin The metabolism of Tolvaptan can be decreased when combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Griseofulvin Griseofulvin The metabolism of Tolvaptan can be increased when combined with Griseofulvin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Tolvaptan.
Loxapine Loxapine The serum concentration of Tolvaptan can be increased when it is combined with Loxapine.
Chloroquine Chloroquine Tolvaptan may increase the excretion rate of Chloroquine which could result in a lower serum level and potentially a reduction in efficacy.
Quinine Quinine The serum concentration of Tolvaptan can be increased when it is combined with Quinine.
Ethosuximide Ethosuximide The risk or severity of hyperkalemia can be increased when Ethosuximide is combined with Tolvaptan.
Calcitriol Calcitriol The metabolism of Tolvaptan can be increased when combined with Calcitriol.
Triamterene Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tolvaptan.
Lactulose Lactulose The risk or severity of adverse effects can be increased when Tolvaptan is combined with Lactulose.
Sulfinpyrazone Sulfinpyrazone The metabolism of Tolvaptan can be increased when combined with Sulfinpyrazone.
Metolazone Metolazone Tolvaptan may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The metabolism of Secobarbital can be increased when combined with Tolvaptan.
Desipramine Desipramine The metabolism of Desipramine can be decreased when combined with Tolvaptan.
Amitriptyline Amitriptyline Tolvaptan may increase the excretion rate of Amitriptyline which could result in a lower serum level and potentially a reduction in efficacy.
Imipramine Imipramine Tolvaptan may increase the excretion rate of Imipramine which could result in a lower serum level and potentially a reduction in efficacy.
Probenecid Probenecid The metabolism of Probenecid can be increased when combined with Tolvaptan.
Quinidine Quinidine The serum concentration of Quinidine can be increased when it is combined with Tolvaptan.
Procainamide Procainamide Tolvaptan may increase the excretion rate of Procainamide which could result in a lower serum level and potentially a reduction in efficacy.
Isoniazid Isoniazid The metabolism of Isoniazid can be decreased when combined with Tolvaptan.
Pyrazinamide Pyrazinamide Tolvaptan may increase the excretion rate of Pyrazinamide which could result in a lower serum level and potentially a reduction in efficacy.
Rifampin Rifampin The serum concentration of Tolvaptan can be decreased when it is combined with Rifampicin.
Disopyramide Disopyramide Tolvaptan may increase the excretion rate of Disopyramide which could result in a lower serum level and potentially a reduction in efficacy.
Valproic Acid Valproic Acid The metabolism of Tolvaptan can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The serum concentration of Tolvaptan can be increased when it is combined with Tamoxifen.
Butabarbital Butabarbital Tolvaptan may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Levothyroxine Levothyroxine The serum concentration of Tolvaptan can be decreased when it is combined with Levothyroxine.
Liothyronine Liothyronine Tolvaptan may increase the excretion rate of Liothyronine which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole Methimazole The metabolism of Methimazole can be decreased when combined with Tolvaptan.
Chlorpropamide Chlorpropamide Tolvaptan may increase the excretion rate of Chlorpropamide which could result in a lower serum level and potentially a reduction in efficacy.
Tolbutamide Tolbutamide Tolvaptan may increase the excretion rate of Tolbutamide which could result in a lower serum level and potentially a reduction in efficacy.
Tolazamide Tolazamide Tolvaptan may increase the excretion rate of Tolazamide which could result in a lower serum level and potentially a reduction in efficacy.
Niacin Niacin The metabolism of Tolvaptan can be decreased when combined with Niacin.
Baclofen Baclofen Tolvaptan may increase the excretion rate of Baclofen which could result in a lower serum level and potentially a reduction in efficacy.
Ethambutol Ethambutol Tolvaptan may increase the excretion rate of Ethambutol which could result in a lower serum level and potentially a reduction in efficacy.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Tolvaptan.
Chlorzoxazone Chlorzoxazone Tolvaptan may increase the excretion rate of Chlorzoxazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyridoxine Pyridoxine Tolvaptan may increase the excretion rate of Pyridoxine which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid Folic Acid Tolvaptan may increase the excretion rate of Folic acid which could result in a lower serum level and potentially a reduction in efficacy.
Danazol Danazol The metabolism of Tolvaptan can be decreased when combined with Danazol.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Tolvaptan may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Tolvaptan.
Spironolactone Spironolactone The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Tolvaptan.
Amphotericin B Injection Amphotericin B Injection The metabolism of Tolvaptan can be decreased when combined with Amphotericin B.
Phytonadione Phytonadione Tolvaptan may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Nadolol Nadolol Tolvaptan may increase the excretion rate of Nadolol which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Tolvaptan can be decreased when used in combination with Nalbuphine.
Allopurinol Allopurinol Tolvaptan may increase the excretion rate of Allopurinol which could result in a lower serum level and potentially a reduction in efficacy.
Clomiphene Clomiphene The serum concentration of Tolvaptan can be increased when it is combined with Clomifene.
Flavoxate Flavoxate Tolvaptan may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy.
Colchicine Colchicine The metabolism of Tolvaptan can be increased when combined with Colchicine.
Cefaclor Cefaclor Tolvaptan may increase the excretion rate of Cefaclor which could result in a lower serum level and potentially a reduction in efficacy.
Cefadroxil Cefadroxil Tolvaptan may increase the excretion rate of Cefadroxil which could result in a lower serum level and potentially a reduction in efficacy.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Tolvaptan.
Dacarbazine Dacarbazine Tolvaptan may increase the excretion rate of Dacarbazine which could result in a lower serum level and potentially a reduction in efficacy.
Acetazolamide Acetazolamide The metabolism of Tolvaptan can be decreased when combined with Acetazolamide.
Calcitonin Salmon Injection Calcitonin Salmon Injection Tolvaptan may increase the excretion rate of Salmon calcitonin which could result in a lower serum level and potentially a reduction in efficacy.
Ketoconazole Ketoconazole The metabolism of Tolvaptan can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Tolvaptan may increase the excretion rate of Pyrantel which could result in a lower serum level and potentially a reduction in efficacy.
Vincristine Injection Vincristine Injection The serum concentration of Vincristine can be increased when it is combined with Tolvaptan.
Captopril Captopril Tolvaptan may increase the hyperkalemic activities of Captopril.
Vinblastine Vinblastine The metabolism of Tolvaptan can be increased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Tolvaptan can be decreased when combined with Metoprolol.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Tolvaptan which could result in a higher serum level.
Salsalate Salsalate The risk or severity of hyperkalemia can be increased when Salsalate is combined with Tolvaptan.
Alprazolam Alprazolam Tolvaptan may increase the excretion rate of Alprazolam which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam Temazepam Tolvaptan may increase the excretion rate of Temazepam which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam Triazolam Tolvaptan may increase the excretion rate of Triazolam which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine Dicyclomine Tolvaptan may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy.
Propantheline Propantheline Tolvaptan may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy.
Trimethoprim Trimethoprim Tolvaptan may increase the excretion rate of Trimethoprim which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem Diltiazem The metabolism of Tolvaptan can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Tolvaptan can be increased when combined with Nifedipine.
Timolol Timolol Tolvaptan may increase the excretion rate of Timolol which could result in a lower serum level and potentially a reduction in efficacy.
Verapamil Verapamil The serum concentration of Tolvaptan can be increased when it is combined with Verapamil.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Tolvaptan.
Pindolol Pindolol Pindolol may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Cisplatin Injection Cisplatin Injection Tolvaptan may increase the excretion rate of Cisplatin which could result in a lower serum level and potentially a reduction in efficacy.
Diflunisal Diflunisal Diflunisal may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Piroxicam Piroxicam Piroxicam may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Bumetanide Bumetanide Tolvaptan may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Etoposide Etoposide The metabolism of Tolvaptan can be increased when combined with Etoposide.
Glyburide Glyburide The metabolism of Tolvaptan can be decreased when combined with Glyburide.
Glipizide Glipizide Tolvaptan may increase the excretion rate of Glipizide which could result in a lower serum level and potentially a reduction in efficacy.
Indapamide Indapamide Tolvaptan may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Tolvaptan may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
Dicloxacillin Dicloxacillin The metabolism of Tolvaptan can be increased when combined with Dicloxacillin.
Nafcillin Injection Nafcillin Injection The metabolism of Tolvaptan can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Tolvaptan may increase the excretion rate of Oxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline Pentoxifylline Tolvaptan may increase the excretion rate of Pentoxifylline which could result in a lower serum level and potentially a reduction in efficacy.
Pentamidine Injection Pentamidine Injection The risk or severity of hyperkalemia can be increased when Pentamidine is combined with Tolvaptan.
Ceftriaxone Injection Ceftriaxone Injection Tolvaptan may increase the excretion rate of Ceftriaxone which could result in a lower serum level and potentially a reduction in efficacy.
Labetalol Labetalol Labetalol may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Auranofin Auranofin Tolvaptan may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection Leuprolide Injection Tolvaptan may increase the excretion rate of Leuprolide which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil Gemfibrozil Tolvaptan may increase the excretion rate of Gemfibrozil which could result in a lower serum level and potentially a reduction in efficacy.
Ceftazidime Injection Ceftazidime Injection Tolvaptan may increase the excretion rate of Ceftazidime which could result in a lower serum level and potentially a reduction in efficacy.
Ketoprofen Ketoprofen Ketoprofen may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Cefotetan Injection Cefotetan Injection Tolvaptan may increase the excretion rate of Cefotetan which could result in a lower serum level and potentially a reduction in efficacy.
Pimozide Pimozide The metabolism of Tolvaptan can be decreased when combined with Pimozide.
Enalapril Enalapril Tolvaptan may increase the hyperkalemic activities of Enalapril.
Flurbiprofen Flurbiprofen Flurbiprofen may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Amiodarone Amiodarone The serum concentration of Tolvaptan can be increased when it is combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Tolvaptan may increase the excretion rate of Aztreonam which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone Buspirone Tolvaptan may increase the excretion rate of Buspirone which could result in a lower serum level and potentially a reduction in efficacy.
Lovastatin Lovastatin The metabolism of Tolvaptan can be decreased when combined with Lovastatin.
Ciprofloxacin Ciprofloxacin The metabolism of Ciprofloxacin can be decreased when combined with Tolvaptan.
Mesalamine Mesalamine The risk or severity of hyperkalemia can be increased when Mesalazine is combined with Tolvaptan.
Diclofenac Diclofenac The risk or severity of hyperkalemia can be increased when Diclofenac is combined with Tolvaptan.
Nimodipine Nimodipine The risk or severity of hyperkalemia can be increased when Nimodipine is combined with Tolvaptan.
Clozapine Clozapine The metabolism of Clozapine can be increased when combined with Tolvaptan.
Estazolam Estazolam Tolvaptan may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Didanosine Didanosine Tolvaptan may increase the excretion rate of Didanosine which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection Pentostatin Injection Tolvaptan may increase the excretion rate of Pentostatin which could result in a lower serum level and potentially a reduction in efficacy.
Clarithromycin Clarithromycin The serum concentration of Tolvaptan can be increased when it is combined with Clarithromycin.
Benazepril Benazepril Tolvaptan may increase the hyperkalemic activities of Benazepril.
Etodolac Etodolac Etodolac may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Felodipine Felodipine The metabolism of Tolvaptan can be decreased when combined with Felodipine.
Fosinopril Fosinopril Tolvaptan may increase the hyperkalemic activities of Fosinopril.
Nabumetone Nabumetone The risk or severity of hyperkalemia can be increased when Nabumetone is combined with Tolvaptan.
Pravastatin Pravastatin The serum concentration of Tolvaptan can be increased when it is combined with Pravastatin.
Quinapril Quinapril Tolvaptan may increase the hyperkalemic activities of Quinapril.
Ramipril Ramipril Tolvaptan may increase the hyperkalemic activities of Ramipril.
Simvastatin Simvastatin The serum concentration of Tolvaptan can be increased when it is combined with Simvastatin.
Amlodipine Amlodipine The risk or severity of hyperkalemia can be increased when Amlodipine is combined with Tolvaptan.
Teniposide Injection Teniposide Injection The metabolism of Tolvaptan can be decreased when combined with Teniposide.
Itraconazole Itraconazole The serum concentration of Tolvaptan can be increased when it is combined with Itraconazole.
Lisinopril Lisinopril Tolvaptan may increase the hyperkalemic activities of Lisinopril.
Oxaprozin Oxaprozin Oxaprozin may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Rifabutin Rifabutin The metabolism of Tolvaptan can be increased when combined with Rifabutin.
Sotalol Sotalol The risk or severity of hyperkalemia can be increased when Sotalol is combined with Tolvaptan.
Bisoprolol Bisoprolol The serum concentration of Tolvaptan can be increased when it is combined with Bisoprolol.
Doxazosin Doxazosin The metabolism of Tolvaptan can be decreased when combined with Doxazosin.
Isradipine Isradipine The metabolism of Tolvaptan can be decreased when combined with Isradipine.
Omeprazole Omeprazole The metabolism of Tolvaptan can be increased when combined with Omeprazole.
Cisapride Cisapride The metabolism of Tolvaptan can be decreased when combined with Cisapride.
Fluvastatin Fluvastatin The metabolism of Tolvaptan can be decreased when combined with Fluvastatin.
Venlafaxine Venlafaxine Tolvaptan may increase the excretion rate of Venlafaxine which could result in a lower serum level and potentially a reduction in efficacy.
Famciclovir Famciclovir The metabolism of Tolvaptan can be decreased when combined with Famciclovir.
Fluvoxamine Fluvoxamine The metabolism of Fluvoxamine can be decreased when combined with Tolvaptan.
Nefazodone Nefazodone The metabolism of Nefazodone can be decreased when combined with Tolvaptan.
Lamotrigine Lamotrigine Lamotrigine may increase the excretion rate of Tolvaptan which could result in a lower serum level and potentially a reduction in efficacy.
Losartan Losartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Losartan.
Valacyclovir Valacyclovir Tolvaptan may increase the excretion rate of Valaciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Tramadol Tramadol Tolvaptan may increase the excretion rate of Tramadol which could result in a lower serum level and potentially a reduction in efficacy.
Carboplatin Injection Carboplatin Injection Tolvaptan may increase the excretion rate of Carboplatin which could result in a lower serum level and potentially a reduction in efficacy.
Moexipril Moexipril Tolvaptan may increase the hyperkalemic activities of Moexipril.
Lansoprazole Lansoprazole The metabolism of Tolvaptan can be increased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Tolvaptan.
Nicardipine Nicardipine The metabolism of Tolvaptan can be decreased when combined with Nicardipine.
Bupropion Bupropion Tolvaptan may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Tolvaptan.
Saquinavir Saquinavir The serum concentration of Tolvaptan can be increased when it is combined with Saquinavir.
Metformin Metformin Tolvaptan may increase the excretion rate of Metformin which could result in a lower serum level and potentially a reduction in efficacy.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Dalteparin.
Nisoldipine Nisoldipine Tolvaptan may increase the excretion rate of Nisoldipine which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine Lamivudine Tolvaptan may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Acarbose Acarbose Tolvaptan may increase the excretion rate of Acarbose which could result in a lower serum level and potentially a reduction in efficacy.
Gemcitabine Injection Gemcitabine Injection Tolvaptan may increase the excretion rate of Gemcitabine which could result in a lower serum level and potentially a reduction in efficacy.
Ritonavir Ritonavir The serum concentration of Tolvaptan can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Tolvaptan can be decreased when combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Tolvaptan may increase the excretion rate of Cidofovir which could result in a lower serum level and potentially a reduction in efficacy.
Meropenem Injection Meropenem Injection Tolvaptan may increase the excretion rate of Meropenem which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine Clomipramine Tolvaptan may increase the excretion rate of Clomipramine which could result in a lower serum level and potentially a reduction in efficacy.
Zafirlukast Zafirlukast The metabolism of Tolvaptan can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Tolvaptan may increase the excretion rate of Fosfomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine Mirtazapine The metabolism of Tolvaptan can be decreased when combined with Mirtazapine.
Trandolapril Trandolapril Tolvaptan may increase the hyperkalemic activities of Trandolapril.
Topiramate Topiramate The metabolism of Topiramate can be increased when combined with Tolvaptan.
Valsartan Valsartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Valsartan.
Pramipexole Pramipexole Tolvaptan may increase the excretion rate of Pramipexole which could result in a lower serum level and potentially a reduction in efficacy.
Fexofenadine Fexofenadine The serum concentration of Tolvaptan can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Tolvaptan can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Tolvaptan can be increased when it is combined with Carvedilol.
Nilutamide Nilutamide Tolvaptan may increase the excretion rate of Nilutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flutamide Flutamide Tolvaptan may increase the excretion rate of Flutamide which could result in a lower serum level and potentially a reduction in efficacy.
Bicalutamide Bicalutamide The metabolism of Tolvaptan can be decreased when combined with Bicalutamide.
Propafenone Propafenone The serum concentration of Tolvaptan can be increased when it is combined with Propafenone.
Raloxifene Raloxifene The metabolism of Tolvaptan can be decreased when combined with Raloxifene.
Irbesartan Irbesartan The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Irbesartan.
Tamsulosin Tamsulosin Tolvaptan may increase the excretion rate of Tamsulosin which could result in a lower serum level and potentially a reduction in efficacy.
Quetiapine Quetiapine Tolvaptan may increase the excretion rate of Quetiapine which could result in a lower serum level and potentially a reduction in efficacy.
Cetirizine Cetirizine Tolvaptan may increase the excretion rate of Cetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Paroxetine Paroxetine The metabolism of Tolvaptan can be decreased when combined with Paroxetine.
Tolcapone Tolcapone Tolvaptan may increase the excretion rate of Tolcapone which could result in a lower serum level and potentially a reduction in efficacy.
Citalopram Citalopram The metabolism of Tolvaptan can be decreased when combined with Citalopram.
Capecitabine Capecitabine Tolvaptan may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Efavirenz Efavirenz The metabolism of Tolvaptan can be increased when combined with Efavirenz.
Abacavir Abacavir Tolvaptan may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Sildenafil Sildenafil The serum concentration of Tolvaptan can be increased when it is combined with Sildenafil.
Celecoxib Celecoxib The risk or severity of hyperkalemia can be increased when Celecoxib is combined with Tolvaptan.
Rosiglitazone Rosiglitazone Tolvaptan may increase the excretion rate of Rosiglitazone which could result in a lower serum level and potentially a reduction in efficacy.
Tolterodine Tolterodine Tolvaptan may increase the excretion rate of Tolterodine which could result in a lower serum level and potentially a reduction in efficacy.
Oseltamivir Oseltamivir Tolvaptan may increase the excretion rate of Oseltamivir which could result in a lower serum level and potentially a reduction in efficacy.
Balsalazide Balsalazide The risk or severity of hyperkalemia can be increased when Balsalazide is combined with Tolvaptan.
Nateglinide Nateglinide Tolvaptan may increase the excretion rate of Nateglinide which could result in a lower serum level and potentially a reduction in efficacy.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Tolvaptan.
Terbinafine Terbinafine The metabolism of Tolvaptan can be increased when combined with Terbinafine.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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