FDA-filed SPL labeling · retrieved through openFDA

Methylergonovine

Methylergonovine is a uterine-stimulating medication used to control bleeding and manage uterine atony after childbirth.

Brand names MethergineMethylergometrine
Drug class Ergot Derivative
Rx Forms 2 Routes Oral · Intravenous · Intramuscular, Intravenous · Intramuscular; Intravenous
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 10 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveJun 12, 2025
Clinical labels in scope 10
AvailabilityRx
Earliest approval/marketing year 1946
FDA-listed product records 35
Boxed warningNone found in compared labels
How we combine label and product data →
No current FDA shortage listed · checked Sep 22, 2026 🚨Recall on record
Methylergonovine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Methylergonovine is a short-term medication used right after childbirth to help the uterus contract and reduce dangerous bleeding. It's very effective for its purpose, but it requires careful monitoring — especially because it can raise blood pressure and interact with many common medications. Always take it exactly as prescribed and let your care team know about every medication and supplement you use.

📖 Methylergonovine: Patient Information Guide

A plain-language walkthrough of Methylergonovine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Methylergonovine is used in the postpartum period to help the uterus contract and prevent or control dangerous bleeding. Here are the supported uses across available products:

  • Management of uterine atony (uterus failing to contract adequately) following delivery of the placenta — supported by Methergine tablets, Methylergonovine Maleate tablets, and Methylergonovine Maleate Injection
  • Management of postpartum hemorrhage (heavy uterine bleeding) after delivery — supported by Methergine tablets, Methylergonovine Maleate tablets, and Methylergonovine Maleate Injection
  • Management of subinvolution of the uterus (when the uterus is slow to shrink back to normal size) — supported by Methergine tablets, Methylergonovine Maleate tablets, and Methylergonovine Maleate Injection
  • Control of uterine hemorrhage during the second stage of labor following delivery of the anterior shoulder — supported by all forms and brands
⚙️How it works

Methylergonovine works by directly stimulating the smooth muscle of the uterus. It increases the tone (firmness), rate, and strength of uterine contractions, producing a rapid and sustained clamp-down effect. This tightening of the uterine muscle compresses the blood vessels inside, reducing blood loss and helping complete the third stage of labor more quickly.

💊How it's taken

Methylergonovine is available as a tablet taken by mouth and as an injection given by a healthcare provider into a muscle (intramuscular) or, in urgent situations, slowly into a vein (intravenous). The tablet is typically taken several times a day during the postpartum period and is not used for longer than one week. The injection may be given after delivery of the shoulder or placenta and can be repeated at intervals as determined by the care team.

  • The IV injection must always be given slowly — over at least 60 seconds — with blood pressure monitoring; it is not used routinely
  • Postpartum women taking the tablet may experience slower absorption during continued use
  • Always follow your prescriber's exact instructions — do not adjust your dose or schedule on your own
🤒Side effects — in detail

The most common side effect is high blood pressure (hypertension), which can sometimes be accompanied by seizures or headache. Other side effects include:

  • Headache
  • Abdominal pain from uterine contractions
  • Nausea and vomiting
  • Low blood pressure (hypotension)
  • Dizziness
  • Leg cramps
  • Rapid or slow heartbeat (tachycardia or bradycardia)
  • Ringing in the ears (tinnitus)

Serious but rare reactions include heart attack, coronary artery spasm, stroke (cerebrovascular accident), ventricular fibrillation, and severe vasospasm (dangerous narrowing of blood vessels). Get emergency help right away if you experience chest pain, severe headache, difficulty breathing, or signs of stroke.

⚠️Warnings & precautions
  • Intravenous use carries real risk: Giving methylergonovine through a vein can cause sudden, severe high blood pressure and stroke. IV use is only for life-threatening emergencies and must be given very slowly with blood pressure monitoring.
  • Coronary artery disease risk: People with coronary artery disease or its risk factors (smoking, obesity, diabetes, high cholesterol) are more vulnerable to vasospasm affecting the heart, which can lead to heart attack.
  • Breastfeeding: Methylergonovine Maleate Injection can harm a nursing baby and may reduce milk production. Do not breastfeed during injection treatment; discard pumped milk during this time and wait at least 12 hours after the last dose before nursing.
  • Newborn safety: This injection has been accidentally given to newborns instead of vitamin K or hepatitis B vaccine, with serious consequences. It must be stored completely separately from medications meant for newborns.
  • Liver or kidney problems: Use with caution — tell your provider if you have any impairment of liver or kidney function.
🔀What it interacts with

Methylergonovine can interact with several medications in ways that may be dangerous. Key interactions to know about:

  • Strong CYP 3A4 inhibitors (certain HIV medications like ritonavir, indinavir, nelfinavir, saquinavir; macrolide antibiotics like clarithromycin; azole antifungals like ketoconazole, itraconazole, voriconazole; and nefazodone) — must NOT be combined; risk of severe vasospasm affecting the brain or limbs
  • Grapefruit juice — a strong CYP 3A4 inhibitor; should be avoided during treatment
  • Moderate CYP 3A4 inhibitors (fluconazole, fluvoxamine, clotrimazole) — should also be avoided
  • Weak CYP 3A4 inhibitors (chlorzoxazone, cilostazol, ranitidine) — use with caution
  • Strong CYP 3A4 inducers (rifampin, nevirapine) — may reduce methylergonovine's effectiveness
  • Beta-blockers — may intensify blood vessel narrowing when combined
  • Certain anesthetics (halothane, methoxyflurane) — may reduce methylergonovine's uterine-stimulating effect
  • Antianginal drugs (e.g., glyceryl trinitrate/nitroglycerin) — methylergonovine's vasoconstrictive effect may reduce their benefit
  • Other vasoconstrictors, ergot alkaloids, or prostaglandins should also be used with caution

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it
  • Do not use if you have high blood pressure (hypertension) — this is a contraindication
  • Do not use if you have toxemia (serious high blood pressure complication of pregnancy) — contraindicated
  • Do not use during pregnancy — it stimulates uterine contractions and is contraindicated
  • Do not use if you have a known allergy (hypersensitivity) to methylergonovine
  • Tell your provider if you have coronary artery disease or risk factors (smoking, obesity, diabetes, high cholesterol) — higher risk of heart-related vasospasm
  • Tell your provider about any liver or kidney problems — caution is needed in these conditions
  • Breastfeeding mothers using the injection should not nurse during treatment; wait at least 12 hours after the last injection dose before resuming breastfeeding
🚑If you take too much

Taking too much methylergonovine can cause nausea, vomiting, abdominal pain, numbness and tingling in the hands and feet, and a sudden rise in blood pressure. In severe cases, overdose can lead to dangerously low blood pressure, difficulty breathing, seizures, low body temperature (hypothermia), and coma. Treatment is supportive and focused on managing each symptom — if you suspect an overdose, call 911 or poison control immediately.

📡Pharmacodynamics — effects in the body

Methylergonovine produces its effects very quickly after administration. When given intravenously, the onset of action is immediate. After an intramuscular injection, the uterus begins responding within 2 to 5 minutes. When taken by mouth as a tablet, the effect begins within 5 to 10 minutes. The drug induces a firm, sustained uterine contraction that shortens the third stage of labor and significantly reduces postpartum blood loss.

🔬Pharmacokinetics — how your body processes it

After an intravenous dose, methylergonovine is rapidly distributed from the bloodstream into body tissues within 2 to 3 minutes. When taken orally, about 60% of the medication is absorbed, with peak blood levels reached in roughly one hour in fasting adults — though postpartum women on continued treatment may absorb it more slowly (peak around 3 hours). The intramuscular injection delivers about 25% more drug into the body compared to the tablet. The medication is primarily broken down and eliminated by the liver, and it clears the body with an average half-life (the time for blood levels to fall by half) of about 3.4 hours.

📦How to store it

STORE AND DISPENSE Tablets: Store below 25°C (77°F); in a tight, light-resistant container.

📄 Written from Methylergonovine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

20

Supplements & herbs that interact with Methylergonovine

20 supplements and herbal products have documented interactions with Methylergonovine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 10
  • Minor · 9
Every supplement checked against Methylergonovine — ranked by severity The full interaction hub: 1 major · 10 moderate · 9 minor · every one linked to its full report. Check Methylergonovine against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Methylergonovine — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is methylergonovine used for?
It's a medication given right after childbirth to help your uterus contract firmly and stop or prevent heavy bleeding. Sometimes the uterus doesn't tighten up on its own the way it should after delivery — that's called uterine atony — and methylergonovine gives it a strong nudge to do its job. It can be given as a shot in the hospital or as a tablet you take at home for up to a week after delivery.
How should I take the tablet form, and is there anything I should know about timing?
You'll typically take the tablet three or four times a day for up to one week after delivery, as your provider directs. One thing worth knowing: if you're taking it continuously in the postpartum period, your body may absorb it a bit more slowly than usual — that's normal. Don't double up on doses if you miss one; just follow the schedule your provider gave you and reach out to them with any questions.
What side effects should I watch out for?
The most common one is high blood pressure, which can sometimes come with a headache or, in rare cases, a seizure — so let your care team know right away if you develop a sudden bad headache, vision changes, or feel unusual. Abdominal cramping from uterine contractions, nausea, and vomiting can also happen. Chest pain, difficulty breathing, or numbness in your hands and feet are serious signs that need immediate medical attention — don't wait on those.
Are there any medications or foods I should avoid while taking this?
Yes — this is really important. Certain medications can dangerously interact with methylergonovine by causing severe narrowing of blood vessels. These include some HIV medications (like ritonavir, indinavir, saquinavir), certain antibiotics (like clarithromycin), antifungals (like ketoconazole), and some antidepressants (like nefazodone). Grapefruit juice is also on the avoid list. Make sure your provider has a full list of everything you take — including over-the-counter drugs and supplements — before starting methylergonovine.
Can I breastfeed while taking this medication?
It depends on which form you're using. If you're receiving Methylergonovine Maleate Injection, you should not breastfeed during treatment — the medication can pass to your baby through breast milk and may also reduce how much milk you produce. Any milk you pump during treatment should be discarded. You'll need to wait at least 12 hours after your last injection dose before nursing again. Talk to your provider or a lactation consultant so you can plan ahead.
Is there anything about my health history that could make this medication riskier for me?
Yes — a few things matter a lot here. Methylergonovine should not be used if you have high blood pressure or certain serious pregnancy-related conditions involving blood pressure. If you have heart disease or risk factors for it — like smoking, obesity, diabetes, or high cholesterol — you're at higher risk for a rare but serious reaction involving spasm of the heart arteries. Also tell your provider if you have liver or kidney problems, as this medication is processed mainly by the liver and extra caution is needed.
Is Methylergonovine available over the counter?
Methylergonovine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Methylergonovine first available?
Methylergonovine has been available in the United States since at least 1946, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Methylergonovine?
Methylergonovine is supplied by 19 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, Teva Pharmaceuticals USA, Inc., West-Ward Pharmaceuticals Corp.

💬 Answers drafted from Methylergonovine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

💊 How Methylergonovine comes

Methylergonovine is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Tablet

By mouth
Brands Methergine
How this form is used
What it may be used for
  • Methergine tablets are used to manage uterine atony, hemorrhage, and subinvolution following delivery of the placenta
  • Methergine tablets are used to control uterine hemorrhage during the second stage of labor after delivery of the anterior shoulder
  • Methylergonovine Maleate tablets share the same postpartum indications as Methergine tablets
Important instructions
  • Methergine and Methylergonovine Maleate tablets are taken by mouth 3 or 4 times daily during the postpartum period
  • Tablet treatment should continue for a maximum of 1 week
  • Postpartum women may absorb the tablet more slowly than usual — absorption may be delayed by about 3 hours during continuous use
Available strengths 1 strength
20 FDA-listed product records

Injection

Into a muscle · Into a vein
How this form is used
What it may be used for
  • Methylergonovine Maleate Injection is used to manage uterine atony, hemorrhage, and subinvolution after delivery of the placenta
  • Methylergonovine Maleate Injection is used to control uterine hemorrhage during the second stage of labor after delivery of the anterior shoulder
Important instructions
  • Methylergonovine Maleate Injection is given intramuscularly after delivery of the anterior shoulder, after delivery of the placenta, or during the postpartum period; doses may be repeated at intervals of 2 to 4 hours as needed
  • Methylergonovine Maleate Injection given intravenously must be administered very slowly — over no less than 60 seconds — with careful blood pressure monitoring; IV use is reserved for urgent situations only
  • Methylergonovine Maleate Injection should be inspected visually for particles or discoloration before use
  • Methylergonovine Maleate Injection must be stored separately from medications intended for newborn infants to prevent accidental administration
Available strengths 1 strength
15 FDA-listed product records

📊 Methylergonovine across the U.S. market

How Methylergonovine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

2
Dose forms
19
Manufacturers
2
Brand names
35
FDA-listed product records
1946
First marketed

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Bryant Ranch Prepack11%
Teva Pharmaceuticals USA, Inc.11%
West-Ward Pharmaceuticals Corp6%
American Health Packaging6%
American Regent, Inc.6%
Amneal Pharmaceuticals NY LLC6%
Other makers54%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Methylergonovine is used

A general measure of how commonly Methylergonovine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Methylergonovine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

5,549
Medicaid prescriptions filled (Q1–Q4 2025)
$366,742 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Methylergonovine prescribed? Of the 1,596 medications we measure, Methylergonovine ranks #1,032 by Medicaid prescriptions — more than 35% of them.

Where Methylergonovine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Methylergonovine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.2 mg oral tablet is the most-dispensed Methylergonovine product — about 71% of these Medicaid prescriptions.

methylergonovine maleate 0.2 MG Oral Tablet Most dispensed

3,922 Medicaid prescriptions (Q1–Q4 2025) 71% of Methylergonovine prescriptions shown $275,779 gross reimbursement (before rebates) ≈ $70 per prescription (gross)

Summed across the 7 of 34 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 996824

1 ML methylergonovine maleate 0.2 MG/ML Injection

1,627 Medicaid prescriptions (Q1–Q4 2025) 29% of Methylergonovine prescriptions shown $90,963 gross reimbursement (before rebates) ≈ $56 per prescription (gross)

Summed across the 3 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 996828

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Methylergonovine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 10 of 44 listed Methylergonovine NDCs with Medicaid activity.

🔍 Compare Methylergonovine products

A representative set of FDA-listed product records for Methylergonovine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 35 of 35 products — FDA National Drug Code Directory. See every product, package size and price: browse all 35 Methylergonovine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Methylergonovine RxCUI 6883 2 dose forms · 3 strengths
  1. Dose form (SCDF) Oral Tablet RxCUI 372859 In current FDA listings
    Clinical drug / strength (SCD) maleate 0.2 MG RxCUI 996824 0.125 MG RxCUI 248629

Look up RxCUI 6883 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Methergine Methylergometrine

🏭 Manufacturers & labelers

Bryant Ranch Prepack 4 Teva Pharmaceuticals USA, Inc. 4 West-Ward Pharmaceuticals Corp 2 American Health Packaging 2 American Regent, Inc. 2 Amneal Pharmaceuticals NY LLC 2 Breckenridge Pharmaceutical, Inc. 2 Granules Pharmaceuticals Inc. 2 HF Acquisition Co LLC, DBA HealthFirst 2 Lupin Pharmaceuticals,Inc. 2 Rising Pharma Holdings, Inc. 2 Pharmacist Pharmaceutical, LLC 2 HF Acquisition Co. LLC. DBA HealthFirst 1 Volley Pharmaceuticals, LLC 1 Novel Laboratories, Inc. 1 Major Pharmaceuticals 1 Lupin Pharmaceuticals, Inc. 1 A-S Medication Solutions 1 Akorn 1

RxNorm drug class

Methylergonovine belongs to the Ergot Derivative class.

Pharmacologic class Ergot Derivative
Drug family (ATC) Ergot alkaloids

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jun 12, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Methylergonovine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Methylergonovine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
10
NDC products indexed
35
Distinct labelers/manufacturers represented
19
Linked representative label
Amneal Pharmaceuticals NY LLC
Linked label effective
Jun 12, 2025
Composite sections available
19
Linked SPL Set ID
a7ec8dfe-9b58-4363-a709-c1b72ee67855
Linked SPL Document ID
5c53f000-01eb-4042-bdb8-e569609413bf
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 10 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Amneal Pharmaceuticals NY LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.