Methylergonovine
Methylergonovine is a uterine-stimulating medication used to control bleeding and manage uterine atony after childbirth.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 10 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
📖 Methylergonovine: Patient Information Guide
A plain-language walkthrough of Methylergonovine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
Methylergonovine is used in the postpartum period to help the uterus contract and prevent or control dangerous bleeding. Here are the supported uses across available products:
- Management of uterine atony (uterus failing to contract adequately) following delivery of the placenta — supported by Methergine tablets, Methylergonovine Maleate tablets, and Methylergonovine Maleate Injection
- Management of postpartum hemorrhage (heavy uterine bleeding) after delivery — supported by Methergine tablets, Methylergonovine Maleate tablets, and Methylergonovine Maleate Injection
- Management of subinvolution of the uterus (when the uterus is slow to shrink back to normal size) — supported by Methergine tablets, Methylergonovine Maleate tablets, and Methylergonovine Maleate Injection
- Control of uterine hemorrhage during the second stage of labor following delivery of the anterior shoulder — supported by all forms and brands
⚙️How it works▾
Methylergonovine works by directly stimulating the smooth muscle of the uterus. It increases the tone (firmness), rate, and strength of uterine contractions, producing a rapid and sustained clamp-down effect. This tightening of the uterine muscle compresses the blood vessels inside, reducing blood loss and helping complete the third stage of labor more quickly.
💊How it's taken▾
Methylergonovine is available as a tablet taken by mouth and as an injection given by a healthcare provider into a muscle (intramuscular) or, in urgent situations, slowly into a vein (intravenous). The tablet is typically taken several times a day during the postpartum period and is not used for longer than one week. The injection may be given after delivery of the shoulder or placenta and can be repeated at intervals as determined by the care team.
- The IV injection must always be given slowly — over at least 60 seconds — with blood pressure monitoring; it is not used routinely
- Postpartum women taking the tablet may experience slower absorption during continued use
- Always follow your prescriber's exact instructions — do not adjust your dose or schedule on your own
🤒Side effects — in detail▾
The most common side effect is high blood pressure (hypertension), which can sometimes be accompanied by seizures or headache. Other side effects include:
- Headache
- Abdominal pain from uterine contractions
- Nausea and vomiting
- Low blood pressure (hypotension)
- Dizziness
- Leg cramps
- Rapid or slow heartbeat (tachycardia or bradycardia)
- Ringing in the ears (tinnitus)
Serious but rare reactions include heart attack, coronary artery spasm, stroke (cerebrovascular accident), ventricular fibrillation, and severe vasospasm (dangerous narrowing of blood vessels). Get emergency help right away if you experience chest pain, severe headache, difficulty breathing, or signs of stroke.
⚠️Warnings & precautions▾
- Intravenous use carries real risk: Giving methylergonovine through a vein can cause sudden, severe high blood pressure and stroke. IV use is only for life-threatening emergencies and must be given very slowly with blood pressure monitoring.
- Coronary artery disease risk: People with coronary artery disease or its risk factors (smoking, obesity, diabetes, high cholesterol) are more vulnerable to vasospasm affecting the heart, which can lead to heart attack.
- Breastfeeding: Methylergonovine Maleate Injection can harm a nursing baby and may reduce milk production. Do not breastfeed during injection treatment; discard pumped milk during this time and wait at least 12 hours after the last dose before nursing.
- Newborn safety: This injection has been accidentally given to newborns instead of vitamin K or hepatitis B vaccine, with serious consequences. It must be stored completely separately from medications meant for newborns.
- Liver or kidney problems: Use with caution — tell your provider if you have any impairment of liver or kidney function.
🔀What it interacts with▾
Methylergonovine can interact with several medications in ways that may be dangerous. Key interactions to know about:
- Strong CYP 3A4 inhibitors (certain HIV medications like ritonavir, indinavir, nelfinavir, saquinavir; macrolide antibiotics like clarithromycin; azole antifungals like ketoconazole, itraconazole, voriconazole; and nefazodone) — must NOT be combined; risk of severe vasospasm affecting the brain or limbs
- Grapefruit juice — a strong CYP 3A4 inhibitor; should be avoided during treatment
- Moderate CYP 3A4 inhibitors (fluconazole, fluvoxamine, clotrimazole) — should also be avoided
- Weak CYP 3A4 inhibitors (chlorzoxazone, cilostazol, ranitidine) — use with caution
- Strong CYP 3A4 inducers (rifampin, nevirapine) — may reduce methylergonovine's effectiveness
- Beta-blockers — may intensify blood vessel narrowing when combined
- Certain anesthetics (halothane, methoxyflurane) — may reduce methylergonovine's uterine-stimulating effect
- Antianginal drugs (e.g., glyceryl trinitrate/nitroglycerin) — methylergonovine's vasoconstrictive effect may reduce their benefit
- Other vasoconstrictors, ergot alkaloids, or prostaglandins should also be used with caution
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Do not use if you have high blood pressure (hypertension) — this is a contraindication
- Do not use if you have toxemia (serious high blood pressure complication of pregnancy) — contraindicated
- Do not use during pregnancy — it stimulates uterine contractions and is contraindicated
- Do not use if you have a known allergy (hypersensitivity) to methylergonovine
- Tell your provider if you have coronary artery disease or risk factors (smoking, obesity, diabetes, high cholesterol) — higher risk of heart-related vasospasm
- Tell your provider about any liver or kidney problems — caution is needed in these conditions
- Breastfeeding mothers using the injection should not nurse during treatment; wait at least 12 hours after the last injection dose before resuming breastfeeding
🚑If you take too much▾
Taking too much methylergonovine can cause nausea, vomiting, abdominal pain, numbness and tingling in the hands and feet, and a sudden rise in blood pressure. In severe cases, overdose can lead to dangerously low blood pressure, difficulty breathing, seizures, low body temperature (hypothermia), and coma. Treatment is supportive and focused on managing each symptom — if you suspect an overdose, call 911 or poison control immediately.
📡Pharmacodynamics — effects in the body▾
Methylergonovine produces its effects very quickly after administration. When given intravenously, the onset of action is immediate. After an intramuscular injection, the uterus begins responding within 2 to 5 minutes. When taken by mouth as a tablet, the effect begins within 5 to 10 minutes. The drug induces a firm, sustained uterine contraction that shortens the third stage of labor and significantly reduces postpartum blood loss.
🔬Pharmacokinetics — how your body processes it▾
After an intravenous dose, methylergonovine is rapidly distributed from the bloodstream into body tissues within 2 to 3 minutes. When taken orally, about 60% of the medication is absorbed, with peak blood levels reached in roughly one hour in fasting adults — though postpartum women on continued treatment may absorb it more slowly (peak around 3 hours). The intramuscular injection delivers about 25% more drug into the body compared to the tablet. The medication is primarily broken down and eliminated by the liver, and it clears the body with an average half-life (the time for blood levels to fall by half) of about 3.4 hours.
📦How to store it▾
STORE AND DISPENSE Tablets: Store below 25°C (77°F); in a tight, light-resistant container.
📄 Written from Methylergonovine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
Supplements & herbs that interact with Methylergonovine
20 supplements and herbal products have documented interactions with Methylergonovine in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 1
- Moderate · 10
- Minor · 9
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Methylergonovine — the kind of thing our pharmacy team would talk through with you at the counter.
What exactly is methylergonovine used for? ▾
How should I take the tablet form, and is there anything I should know about timing? ▾
What side effects should I watch out for? ▾
Are there any medications or foods I should avoid while taking this? ▾
Can I breastfeed while taking this medication? ▾
Is there anything about my health history that could make this medication riskier for me? ▾
Is Methylergonovine available over the counter? ▾
When was Methylergonovine first available? ▾
Who makes Methylergonovine? ▾
💬 Answers drafted from Methylergonovine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Methylergonovine comes
Methylergonovine is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Methergine tablets are used to manage uterine atony, hemorrhage, and subinvolution following delivery of the placenta
- Methergine tablets are used to control uterine hemorrhage during the second stage of labor after delivery of the anterior shoulder
- Methylergonovine Maleate tablets share the same postpartum indications as Methergine tablets
- Methergine and Methylergonovine Maleate tablets are taken by mouth 3 or 4 times daily during the postpartum period
- Tablet treatment should continue for a maximum of 1 week
- Postpartum women may absorb the tablet more slowly than usual — absorption may be delayed by about 3 hours during continuous use
Injection
How this form is used
- Methylergonovine Maleate Injection is used to manage uterine atony, hemorrhage, and subinvolution after delivery of the placenta
- Methylergonovine Maleate Injection is used to control uterine hemorrhage during the second stage of labor after delivery of the anterior shoulder
- Methylergonovine Maleate Injection is given intramuscularly after delivery of the anterior shoulder, after delivery of the placenta, or during the postpartum period; doses may be repeated at intervals of 2 to 4 hours as needed
- Methylergonovine Maleate Injection given intravenously must be administered very slowly — over no less than 60 seconds — with careful blood pressure monitoring; IV use is reserved for urgent situations only
- Methylergonovine Maleate Injection should be inspected visually for particles or discoloration before use
- Methylergonovine Maleate Injection must be stored separately from medications intended for newborn infants to prevent accidental administration
📊 Methylergonovine across the U.S. market
How Methylergonovine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
📈 How widely Methylergonovine is used
A general measure of how commonly Methylergonovine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Methylergonovine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Methylergonovine prescribed? Of the 1,596 medications we measure, Methylergonovine ranks #1,032 by Medicaid prescriptions — more than 35% of them.
Utilization by Methylergonovine product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
methylergonovine maleate 0.2 MG Oral Tablet Most dispensed
Summed across the 7 of 34 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 996824
1 ML methylergonovine maleate 0.2 MG/ML Injection
Summed across the 3 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 996828
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Methylergonovine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 10 of 44 listed Methylergonovine NDCs with Medicaid activity.
🔍 Compare Methylergonovine products
A representative set of FDA-listed product records for Methylergonovine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Injection | ||||
| 0.2 mg/mL | Intravenous | A-S Medication Solutions | ANDA | Find on DailyMed ↗ |
| 0.2 mg/mL | Intramuscular; Intravenous | Akorn | ANDA | Find on DailyMed ↗ |
| 0.2 mg/mL | Intramuscular, Intravenous | American Regent, Inc. | ANDA | View NDC → |
| 0.2 mg/mL | Intramuscular; Intravenous | American Regent, Inc. | ANDA | View NDC → |
| 0.2 mg/mL | Intravenous | Breckenridge Pharmaceutical, Inc. × 2 listings | ANDA | View NDC → |
| 0.2 mg/mL | Intravenous | Bryant Ranch Prepack × 4 listings | ANDA | View NDC → |
| 0.2 mg/mL | Intramuscular, Intravenous | HF Acquisition Co. LLC. DBA HealthFirst | ANDA | View NDC → |
| 0.2 mg/mL | Intravenous | HF Acquisition Co LLC, DBA HealthFirst × 2 listings | ANDA | View NDC → |
| 0.2 mg/mL | Intramuscular, Intravenous | Pharmacist Pharmaceutical, LLC | ANDA | View NDC → |
| 0.2 mg/mL | Intramuscular; Intravenous | Pharmacist Pharmaceutical, LLC | ANDA | View NDC → |
| 💊Tablet | ||||
| 0.2 mg | Oral | American Health Packaging × 2 listings | ANDA | View NDC → |
| 0.2 mg | Oral | Amneal Pharmaceuticals NY LLC × 2 listings | ANDA | View NDC → |
| 0.2 mg | Oral | Granules Pharmaceuticals Inc. × 2 listings | ANDA | View NDC → |
| 0.2 mg | Oral | Lupin Pharmaceuticals, Inc. | ANDA | View NDC → |
| 0.2 mg | Oral | Lupin Pharmaceuticals,Inc. × 2 listings | ANDA | View NDC → |
| 0.2 mg | Oral | Major Pharmaceuticals | ANDA | View NDC → |
| 0.2 mg | Oral | Novel Laboratories, Inc. | ANDA | View NDC → |
| 0.2 mg | Oral | Rising Pharma Holdings, Inc. × 2 listings | ANDA | View NDC → |
| 0.2 mg | Oral | Teva Pharmaceuticals USA, Inc. × 4 listings | ANDA | View NDC → |
| 0.2 mg | Oral | Volley Pharmaceuticals, LLC | ANDA | View NDC → |
| 0.2 mg | Oral | West-Ward Pharmaceuticals Corp × 2 listings | ANDA | View NDC → |
Showing 35 of 35 products — FDA National Drug Code Directory. See every product, package size and price: browse all 35 Methylergonovine NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Methylergonovine — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Methylergonovine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Methylergonovine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 6883 2 dose forms · 3 strengths
-
Dose form (SCDF) Injection RxCUI 1740921In current FDA listingsClinical drug / strength (SCD) 1 ML methylergonovine maleate 0.2 MG/MLRxCUI 996828 -
Dose form (SCDF) Oral Tablet RxCUI 372859In current FDA listings
Look up RxCUI 6883 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Methylergonovine is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
RxNorm drug class
Methylergonovine belongs to the Ergot Derivative class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 10 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Amneal Pharmaceuticals NY LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.