Methylergonovine

226 interactions 106 cited references

Also sold as: Methergine Methergine® Methylergometrine

About Methylergonovine

Methylergonovine belongs to a class of drugs called ergot alkaloids. Methylergonovine is used to prevent or treat bleeding from the uterus that can happen after childbirth or an abortion. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Methylergonovine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Boceprevir Dihydroergotamine Injection Almotriptan Atazanavir Zolmitriptan Dinoprostone

30 Contraindicated 192 Major 4 Moderate

All (226) Contraindicated (30) Major (192) Moderate (4)

Contraindicated

Methylergonovine Dihydroergotamine Injection DHE-45® Injection An increased risk of ergotism Details Methylergonovine Dihydroergotamine Nasal Spray Migranal An increased risk of ergotism Details Methylergonovine Dinoprostone Cervidil An increased risk of oxytocic toxicity (uterine hyperstimulation) Details Methylergonovine Ketoconazole Topical Extina® Foam Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Almotriptan Prolonged vasospastic reactions Details Methylergonovine Atazanavir Reyataz An increased risk of peripheral vasospasm and ischemia of the extremities and other tissues Details Methylergonovine Boceprevir An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Methylergonovine Cobicistat Tybost An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Methylergonovine Darunavir An increased risk of acute ergot toxicity (peripheral vasospasm, ischemia of the extremities) Details Methylergonovine Dihydroergotamine Brekiya An increased risk of ergotism Details Methylergonovine Eletriptan Relpax Increased risk of prolonged vasospastic reactions Details Methylergonovine Ensitrelvir Increased ergot derivatives exposure; an increased risk of ergot derivatives-related toxicity Details Methylergonovine Frovatriptan Frova Prolonged vasospastic reactions Details Methylergonovine Indinavir Increased ergot derivative exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Itraconazole Sporanox An increased risk of ergotism (vasospasm leading to cerebral ischemia and/or ischemia of the extremities) Details Methylergonovine Ketoconazole Extina Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Lopinavir An increased risk of methylergonovine toxicity including nausea, vomiting, and vasospastic ischemia Details Methylergonovine Naratriptan Prolonged vasospastic reactions Details Methylergonovine Nefazodone Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Nelfinavir Viracept Increased methylergonovine exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Nirmatrelvir Increased risk of ergot toxicity Details Methylergonovine Ritonavir Norvir Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Rizatriptan Prolonged vasospastic reactions Details Methylergonovine Saquinavir Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Sumatriptan Imitrex Prolonged vasospastic reactions Details Methylergonovine Telaprevir An increased risk of acute ergot toxicity Details Methylergonovine Telithromycin An increased risk of acute ergot toxicity Details Methylergonovine Tipranavir Aptivus An increased risk of methylergonovine toxicity including nausea, vomiting, and vasospastic ischemia Details Methylergonovine Voriconazole Vfend Increased ergot derivative exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Methylergonovine Zolmitriptan Zomig Prolonged vasospastic reactions Details

Major

Methylergonovine Asciminib Scemblix Increased methylergonovine exposure Details Methylergonovine Atenolol Tenormin An increased risk of enhanced vasoconstrictive Details Methylergonovine Azithromycin AzaSite Increased methylergonovine exposure Details Methylergonovine Belumosudil Rezurock Increased methylergonovine exposure Details Methylergonovine Bicalutamide Casodex Increased methylergonovine exposure Details Methylergonovine Acebutolol Sectral® An increased risk of enhanced vasoconstrictive Details Methylergonovine Atorvastatin Atorvaliq Increased methylergonovine exposure Details Methylergonovine Amlodipine Amvaz® Increased methylergonovine exposure Details Methylergonovine Betaxolol Betoptic S An increased risk of enhanced vasoconstrictive Details Methylergonovine Betaxolol Ophthalmic Betoptic® An increased risk of enhanced vasoconstrictive Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.