Inactive ingredients by manufacturer

Topotecan inactive ingredients by manufacturer

Wondering whether your Topotecan has lactose, gluten, soy, a dye or gelatin in it? The medicine is the same, but the fillers, coatings and colors differ from one company to the next. This page shows what each Topotecan product's FDA label lists, so you can find a version that leaves out what you avoid and ask your pharmacist for it by its NDC.

We have read the FDA labels of 8 of the 8 current Topotecan products on the market today, from 7 companies listing it with the FDA, and lined them up side by side.

Ask about your bottle

Is there something in your Topotecan? Ask in plain words.

Name the company, strength or the NDC on your bottle and the ingredient you avoid. The answer comes only from the FDA labels on this page.

Answers are drawn from the FDA label data on this page and checked against it. They are not medical advice: confirm with your pharmacist before relying on them.

The short answer

Which Topotecan products list lactose, a gluten source, soy, dyes or gelatin?

  1. LactoseNo checked product

    No checked Topotecan product lists lactose.

  2. Wheat or gluten sourceNo checked product

    No checked Topotecan product lists a wheat or gluten source.

  3. SoyNo checked product

    No checked Topotecan product lists soy.

  4. Synthetic dyesNo checked product

    No checked Topotecan product lists synthetic dyes.

  5. GelatinDiffers by manufacturer

    2 of 8 checked products list gelatin; 6 do not. See the products

    Does not list it Accord Healthcare, Inc. Accord Healthcare Inc. Actavis Fresenius Kabi Hospira Novartis
    Lists it Sandoz

Also listed by some products: Titanium dioxide 2 of 8 Sorbitol or mannitol 4 of 8

Find a version without it

Every current Topotecan product and what its label lists

Hide products that list:

ProductListsInactive ingredients on the label
Accord Healthcare, Inc. 1 product
4 mg/4 mL injectionNDC 16729-0151-31 Sorbitol or mannitol
Show 4 ingredients

HYDROCHLORIC ACID, MANNITOL, SODIUM HYDROXIDE, TARTARIC ACID
Accord Healthcare Inc. 1 product
1 mg/mL injectionNDC 16729-0243-31 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE, TARTARIC ACID, WATER
Actavis Pharma, Inc. 1 product
4 mg/4 mL injectionNDC 45963-0615-56 Sorbitol or mannitol
Show 4 ingredients

HYDROCHLORIC ACID, MANNITOL, SODIUM HYDROXIDE, TARTARIC ACID
Fresenius Kabi USA, LLC 1 product
4 mg/4 mL injectionNDC 63323-0762-10 Sorbitol or mannitol
Show 4 ingredients

HYDROCHLORIC ACID, MANNITOL, SODIUM HYDROXIDE, TARTARIC ACID
Hospira, Inc. 1 product
1 mg/mL injectionNDC 00409-0302-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE, TARTARIC ACID, WATER
Novartis Pharmaceuticals Corporation 1 product
4 mg/4 mL injectionNDC 00078-0674-61 Sorbitol or mannitol
Show 4 ingredients

HYDROCHLORIC ACID, MANNITOL, SODIUM HYDROXIDE, TARTARIC ACID
Sandoz Inc 2 products
0.25 mg capsuleNDC 66758-0101-11 Titanium dioxide Gelatin
Show 5 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, GLYCERYL MONOSTEARATE, HYDROGENATED PALM OIL, TITANIUM DIOXIDE
1 mg capsuleNDC 66758-0102-11 Titanium dioxide Gelatin
Show 5 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, GLYCERYL MONOSTEARATE, HYDROGENATED PALM OIL, TITANIUM DIOXIDE

A product with none of these listed is not certified to be without them: the label says what the manufacturer declared, and the source of a starch or a flavor is often not stated. The companies are the FDA's labelers, which include repackagers and distributors selling another company's product under their own label. The NDC opens the product's own page, with the full label and its inactive-ingredient notes.

Topotecan without gelatin

Gelatin: animal-derived (usually bovine or porcine); a concern for vegetarian, kosher or halal needs. 2 of 8 checked products list gelatin; 6 do not.

Does not list gelatin

Lists gelatin

Topotecan without titanium dioxide

Titanium dioxide: A white colorant some people choose to avoid. 2 of 8 checked products list titanium dioxide; 6 do not.

Does not list titanium dioxide

Lists titanium dioxide

Topotecan without sorbitol or mannitol

Sorbitol or mannitol: sugar alcohols that can cause bloating or diarrhea in larger amounts. 4 of 8 checked products list sorbitol or mannitol; 4 do not.

Does not list sorbitol or mannitol

Lists sorbitol or mannitol

At the pharmacy counter

How to use this at the pharmacy counter

  1. Pick the company whose list suits you and copy the NDC from the table. Many pharmacies order from wholesalers that carry several companies' versions and can request a particular one if you ask before the prescription is filled; some buy from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check.
  2. Treat "does not list" as exactly that. The label is what the manufacturer declared; a flavor or a starch may have an unstated source, and lines change. For celiac disease or a serious allergy, ask the manufacturer's medical information line for a written statement about the lot you have.
  3. Check the bottle each refill. A different company usually means a different shape, color and inactive-ingredient list; the pharmacist can tell you who made it, and the two-NDC comparison shows the difference line by line.
  4. If you need one company's version kept constant, ask your prescriber to write that company or the NDC on the prescription and tell the pharmacy you need it held. Rules vary by state and plan, so confirm with the pharmacist.
Ask Dr. Staiger which Topotecan product suits you →

Common questions about Topotecan inactive ingredients

Is Topotecan gluten-free?
This page cannot certify any Topotecan product gluten-free; it reports what each label declares. Of the 8 products checked, none lists a wheat, barley, rye or gluten ingredient, and none lists a starch without a stated source. If you have celiac disease, ask the manufacturer's medical information line for a written gluten statement for the lot you have.
Does Topotecan contain lactose?
No checked Topotecan product lists lactose on its label. The lactose in a tablet or capsule is a small amount, but people with a milk allergy or a strong intolerance often prefer a version that does not list it.
Does Topotecan contain soy?
No checked Topotecan product lists a soy ingredient (soybean oil or soy lecithin) on its label. Soy lecithin is the usual form and the amount is small, but people with a soy allergy often prefer a version that does not list it.
Is there a dye-free Topotecan?
No checked Topotecan product lists a synthetic dye (an FD&C or D&C colorant) on its label. Colorants often differ by strength within one company's line, so compare the lists above strength by strength.
Does Topotecan contain gelatin?
2 of 8 checked Topotecan products list gelatin; 6 do not: Accord Healthcare, Inc. (4 mg/4 mL injection), Accord Healthcare Inc. (1 mg/mL injection), Actavis (4 mg/4 mL injection) and Fresenius Kabi (4 mg/4 mL injection) and 2 other companies. Gelatin is usually bovine or porcine and the label rarely says which; for kosher, halal or vegetarian needs, ask the manufacturer.
Why do the inactive ingredients differ between manufacturers?
A generic must match the brand's active ingredient, strength, dose form and how it is absorbed; its fillers, binders, coatings and colorants are the manufacturer's own choice. That is why one Topotecan product can list lactose and a dye while another from a different company lists neither.
Can my pharmacy give me a specific manufacturer's version?
Often, if you ask before the prescription is filled: many pharmacies order from wholesalers that carry several companies' versions and can request a particular one. Some pharmacies buy a generic from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check. Give them the NDC from this page; the company name alone is often enough.
How current is this list?
The products are the ones in the FDA's current NDC directory as of October 6, 2026, and each inactive-ingredient list is the manufacturer's FDA label as our label sync last read it. Formulations change, so check the label on your own bottle and ask your pharmacist if a refill looks different.

Sources: the products are the finished Topotecan products in the FDA's current NDC directory (openFDA), as of October 6, 2026; each inactive-ingredient list is the manufacturer's FDA Structured Product Label via DailyMed, as our label sync last read it. The concern groups are HelloPharmacist's classification of the names the label declares. Educational information only, not medical advice; confirm with your pharmacist before relying on a list. ← Back to the Topotecan guide