Trandolapril and Verapamil
Trandolapril and verapamil is a combination blood pressure medicine that pairs an ACE inhibitor with a calcium channel blocker to treat high blood pressure (hypertension).
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾
Do not use this medicine during pregnancy. Drugs like trandolapril, which act on the renin-angiotensin system, can injure or even kill a developing baby. The risk is highest in the second and third trimesters. It can reduce the baby's kidney function and lead to low amniotic fluid, underdeveloped lungs, skull and bone problems, and death.
If you become pregnant, contact your doctor right away. The label says to stop this medicine as soon as pregnancy is detected.
📖 Trandolapril and Verapamil: Patient Information Guide
A plain-language walkthrough of Trandolapril and Verapamil — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
What Trandolapril and Verapamil is used for
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This combination is approved for one use.
- Treating high blood pressure (hypertension) with trandolapril and verapamil hydrochloride extended-release tablets.
- It is not for starting treatment. It is usually used after one of its ingredients alone did not work well enough or could not be increased because of side effects.
How Trandolapril and Verapamil works
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Verapamil is a calcium channel blocker. It limits calcium entering the cells of blood vessel walls and heart muscle, which relaxes the vessels and lowers resistance to blood flow.
Trandolapril is an ACE inhibitor. It blocks the enzyme that makes angiotensin II, a substance that tightens blood vessels. This lowers blood pressure and reduces the hormone aldosterone, which can slightly raise potassium.
How Trandolapril and Verapamil is taken (dosage)
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These extended-release tablets are taken by mouth once a day, with food. Food lowers how much verapamil your body absorbs, so take them consistently with food each day.
- Follow your prescriber's directions and the label.
- People already taking both medicines as separate once-daily tablets may be switched to this combination at the same component doses.
Trandolapril and Verapamil side effects in detail
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Side effects are usually mild and short-lived. Common ones include:
- Cough
- Headache
- Constipation
- Dizziness
- Fatigue
- Chest pain
- Slower heart rate or first-degree AV block
- Raised liver enzymes on blood tests
Get help right away for swelling of the face, lips, tongue or throat, fainting, a very slow heartbeat, or yellow skin or eyes.
Trandolapril and Verapamil warnings and precautions
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- Pregnancy: can cause fetal injury and death. Stop it as soon as pregnancy is detected.
- Angioedema: serious swelling that can block the airway. Stop the medicine and get emergency care.
- Low blood pressure: more likely if you are dehydrated, salt-depleted, or taking diuretics.
- Heart problems: verapamil can slow the heartbeat, cause heart block, and worsen heart failure.
- Liver: liver enzyme rises and, rarely, serious liver injury can occur. Periodic liver tests are prudent.
- Blood counts: rare drops in white blood cells are possible with ACE inhibitors, especially with kidney or collagen vascular disease.
Trandolapril and Verapamil interactions: what it interacts with
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Several medicines can clash with this combination.
- Sacubitril/valsartan: must not be combined, because of angioedema risk.
- Aliskiren and other RAS blockers: raise risks of low blood pressure, high potassium and kidney problems.
- Flibanserin: must not be combined.
- Ivabradine: can worsen slow heartbeat.
- Digoxin: levels can rise.
- Lithium: levels and toxicity risk can rise.
- Colchicine: combined use is not recommended.
- Erythromycin, clarithromycin, ritonavir, rifampin: can change verapamil levels or cause low blood pressure and slow rhythms.
- Flecainide, quinidine, disopyramide: can add heart effects or cause low blood pressure.
- Other blood pressure medicines: can add to the blood pressure-lowering effect.
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
Before taking Trandolapril and Verapamil
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- Do not use during pregnancy.
- Do not use if you are allergic to any ACE inhibitor or verapamil, or have had angioedema with an ACE inhibitor.
- Do not use with severe left ventricular dysfunction, very low blood pressure, cardiogenic shock, sick sinus syndrome, or second- or third-degree AV block (unless you have a working pacemaker).
- Do not use with atrial fibrillation or flutter plus an accessory bypass tract.
- Use caution with liver disease, kidney disease, or collagen vascular disease.
- Tell your doctor if you are dehydrated or on diuretics.
Trandolapril and Verapamil overdose: if you take too much
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Too much verapamil can cause very low blood pressure, a slow heartbeat, and heart conduction problems. It can also cause metabolic acidosis, high blood sugar, kidney problems and convulsions. Treat any overdose as serious and seek emergency help. Observation for at least 48 hours is advised, because effects can be delayed with sustained-release forms.
Pharmacodynamics: what Trandolapril and Verapamil does in the body
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Verapamil lowers blood pressure by reducing resistance in the blood vessels, usually without a drop in blood pressure on standing or a racing heartbeat. Trandolapril lowers angiotensin II and aldosterone, which relaxes vessels and can slightly raise potassium. Together their blood pressure effect is roughly additive.
Pharmacokinetics: how your body processes Trandolapril and Verapamil
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After a dose, trandolapril peaks within about 0.5 to 2 hours and verapamil within about 4 to 15 hours. Trandolapril is converted to its active form, trandolaprilat. A high-fat meal lowers verapamil absorption and delays its peak by about 7 hours. Steady levels are reached after about a week of once-daily dosing.
How to store Trandolapril and Verapamil
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Dispense in well-closed container with safety closure. Store at 20°C to 25°C (68°F to 77°F) .
📄 Written from Trandolapril and Verapamil’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
🩺 Trandolapril and Verapamil: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Trandolapril and Verapamil — the kind of thing our pharmacy team would talk through with you at the counter.
What is this medicine for?
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How should I take it?
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What side effects are common?
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When should I call my doctor or get emergency help?
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Is it safe if I'm pregnant or might become pregnant?
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Do I need to tell my pharmacist about my other medicines?
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Is Trandolapril and Verapamil available over the counter?
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When was Trandolapril and Verapamil first available?
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💬 Answers drafted from Trandolapril and Verapamil’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 More about Trandolapril and Verapamil on HelloPharmacist
💊 Trandolapril and Verapamil forms and strengths (how it comes)
Trandolapril and Verapamil is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Extended-release tablet
How this form is used
- Trandolapril and Verapamil Hydrochloride extended-release tablets are used to treat high blood pressure, but not as the first treatment.
- Trandolapril and Verapamil Hydrochloride extended-release tablets should be taken with food.
- Trandolapril and Verapamil Hydrochloride extended-release tablets have been studied only as a once-a-day dose.
- Trandolapril and Verapamil Hydrochloride extended-release tablets may replace separate trandolapril and verapamil tablets for some people already taking both once daily. Your prescriber decides.
📊 Trandolapril and Verapamil on the U.S. market: products, makers and brands
How Trandolapril and Verapamil appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
🔍 Compare Trandolapril and Verapamil products
A representative set of FDA-listed product records for Trandolapril and Verapamil — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Extended-release tablet | ||||
| TRANDOLAPRIL 1 mg/1; VERAPAMIL HYDROCHLORIDE 240 mg | Oral | Glenmark Pharmaceuticals Inc., USA | ANDA | View NDC → |
| TRANDOLAPRIL 2 mg/1; VERAPAMIL HYDROCHLORIDE 180 mg | Oral | Glenmark Pharmaceuticals Inc., USA | ANDA | View NDC → |
| TRANDOLAPRIL 2 mg/1; VERAPAMIL HYDROCHLORIDE 240 mg | Oral | Glenmark Pharmaceuticals Inc., USA | ANDA | View NDC → |
| TRANDOLAPRIL 4 mg/1; VERAPAMIL HYDROCHLORIDE 240 mg | Oral | Glenmark Pharmaceuticals Inc., USA | ANDA | View NDC → |
| 1; 240 mg/1; mg | Oral | Glenmark Pharmaceuticals Inc., USA × 2 listings | ANDA | View NDC → |
| 2; 180 mg/1; mg | Oral | Glenmark Pharmaceuticals Inc., USA × 2 listings | ANDA | View NDC → |
| 2; 240 mg/1; mg | Oral | Glenmark Pharmaceuticals Inc., USA × 2 listings | ANDA | View NDC → |
| 4; 240 mg/1; mg | Oral | Glenmark Pharmaceuticals Inc., USA × 2 listings | ANDA | View NDC → |
Showing 12 of 12 products — FDA National Drug Code Directory. See every product, package size and price: browse all 12 Trandolapril and Verapamil NDCs →
📈 Trandolapril and Verapamil side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Trandolapril and Verapamil — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Trandolapril and Verapamil in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ Trandolapril and Verapamil FDA approval history
How Trandolapril and Verapamil went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Trandolapril and Verapamil recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.
RxCUI 214866 2 dose forms · 5 strengths
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Dose form (SCDF) Extended Release Oral Capsule RxCUI 379582No current FDA listingClinical drug / strength (SCD) 24 HR trandolapril 2 MG / verapamil hydrochloride 180 MGRxCUI 411759 -
Dose form (SCDF) Extended Release Oral Tablet RxCUI 374178In current FDA listingsClinical drug / strength (SCD) 24 HR trandolapril 1 MG / verapamil hydrochloride 240 MGRxCUI 89778124 HR trandolapril 2 MG / verapamil hydrochloride 180 MGRxCUI 89778324 HR trandolapril 2 MG / verapamil hydrochloride 240 MGRxCUI 89784424 HR trandolapril 4 MG / verapamil hydrochloride 240 MGRxCUI 897853
Look up RxCUI 214866 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Trandolapril and Verapamil supply and shortage status
Whether Trandolapril and Verapamil is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏭 Who makes Trandolapril and Verapamil: manufacturers and labelers
Trandolapril and Verapamil drug class (RxNorm)
Trandolapril and Verapamil belongs to the Calcium Channel Blocker class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Sources for this Trandolapril and Verapamil page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 1 FDA-filed SPL label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Glenmark Pharmaceuticals Inc., USA is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.