Aleve PM DIPHENHYDRAMINE HYDROCHLORIDE and NAPROXEN SODIUM 25 mg; 220 mg Tablet, Film Coated, 160-count
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Patient education
Supplement & herbal interactions
Where does this data come from?
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Where does this data come from?
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII LMI26O6933
Alumina is a white powder form of aluminum oxide. It's used as a filler to add bulk to tablets and capsules, and sometimes as a thickening or anti-caking agent in powdered formulations.
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UNII R12CBM0EIZ
A natural wax derived from a Brazilian palm tree, used as a coating and polish on tablets and capsules. It creates a smooth, shiny finish that protects the medicine and improves appearance.
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UNII OP1R32D61U
Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
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UNII L06K8R7DQK
A synthetic blue dye approved by the FDA for use in medications and foods. It serves as a colorant to make pills and liquids visually distinct and easier to identify.
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UNII 3NXW29V3WO
Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
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UNII 70097M6I30
Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
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UNII 3WJQ0SDW1A
Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
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UNII FZ989GH94E
Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
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UNII 7SEV7J4R1U
A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
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UNII 15FIX9V2JP
Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
11 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good sense naproxen sodium 25 mg/1; 220 mg 00113-8264-58 | L. | 40 tablets | — | — | Discontinued | — |
| Aleve PM 25 mg/1; 220 mgthis 00280-1200-03 | Bayer | 160 tablets | — | — | FDA listed | — |
| All Night Pain Relief Pm 25 mg/1; 220 mg 00363-2264-27 | Walgreen | 80 tablets | — | — | FDA listed | — |
| up and up naproxen sodium pm 25 mg/1; 220 mg 11673-0687-27 | Target | 80 tablets | — | — | FDA listed | — |
| Naproxen Sodium and Diphenhydramine HCL 25 mg/1; 220 mg 11673-0819-08 | TARGET | 80 tablets | — | — | FDA listed | — |
| Naproxen Sodium Pm 25 mg/1; 220 mg 21130-0639-71 | Safeway | 50 tablets | — | — | FDA listed | — |
| Naproxen Sodium Diphenhydramine Hydrochloride 220 mg/1; 25 mg 21130-0814-05 | SAFEWAY | 50 tablets | — | — | FDA listed | — |
| naproxen sodium pm 25 mg/1; 220 mg 30142-0383-60 | Kroger | 20 tablets | — | — | Discontinued | — |
| naproxen sodium pm 25 mg/1; 220 mg 30142-0753-27 | Kroger | 80 tablets | — | — | FDA listed | — |
| topcare all night pain relief pm 25 mg/1; 220 mg 36800-0264-27 | Topco | 80 tablets | — | — | FDA listed | — |
| naproxen sodium pm 25 mg/1; 220 mg 37808-0264-27 | H | 80 tablets | — | — | FDA listed | — |
| equaline naproxen sodium pm 25 mg/1; 220 mg 41163-0593-58 | United | 40 tablets | — | — | Discontinued | — |
| naproxen sodium pm 25 mg/1; 220 mg 41250-0526-27 | Meijer | 80 tablets | — | — | FDA listed | — |
| careone naproxen sodium pm 25 mg/1; 220 mg 41520-0264-27 | American | 80 tablets | — | — | FDA listed | — |
| dg health naproxen sodium pm 25 mg/1; 220 mg 55910-0858-27 | Dolgencorp | 80 tablets | — | — | FDA listed | — |
| Naproxen Sodium PM 220 mg/1; 25 mg 62011-0396-01 | Strategic | 20 tablets | — | — | Discontinued | — |
| Naproxen Sodium and Diphenhydramine HCl 220 mg/1; 25 mg 62207-0814-38 | Granules | 37500 tablets | — | — | FDA listed | — |
| Naproxen Sodium and Diphenhydramine HCl 220 mg/1; 25 mg 69238-1422-02 | Amneal | 20 tablets | — | — | FDA listed | — |
| Naproxen Sodium Diphenhydramine HCl 220 mg/1; 25 mg 69842-0328-02 | CVS | 20 tablets | — | — | FDA listed | — |
| Naproxen Sodium PM 220 mg/1; 25 mg 70677-0064-01 | Strategic | 20 tablets | — | — | FDA listed | — |
| basic care naproxen sodium pm 25 mg/1; 220 mg 72288-0310-06 | Amazon.com | 160 tablets | — | — | FDA listed | — |
| Naproxen Sodium Diphenhydramine HCL 25 mg/1; 220 mg 79903-0204-20 | Walmart | 20 tablets | — | — | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
The FDA lists approved generic versions of this medicine, but that does not always mean a pharmacy can get one today. Patent rules, launch agreements, supply and pricing can affect when generics actually arrive.
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 00280-1200-01 | 1 BOTTLE in 1 CARTON (0280-1200-01) / 120 TABLET, FILM COATED in 1 BOTTLE | 2014-09-09 | Active |
| 00280-1200-02 | 2 TABLET, FILM COATED in 1 POUCH (0280-1200-02) | 2014-09-09 | Active |
| 00280-1200-03 You're viewing this | 160 TABLET, FILM COATED in 1 BOTTLE (0280-1200-03) | 2014-09-09 | Active |
| 00280-1200-04 | 1 BOTTLE in 1 CARTON (0280-1200-04) / 40 TABLET, FILM COATED in 1 BOTTLE | 2014-09-09 | Active |
| 00280-1200-05 | 80 TABLET, FILM COATED in 1 BOTTLE (0280-1200-05) | 2014-09-09 | Active |
| 00280-1200-08 | 1 BOTTLE in 1 CARTON (0280-1200-08) / 250 TABLET, FILM COATED in 1 BOTTLE | 2021-07-01 | Active |
| 00280-1200-20 | 1 BOTTLE in 1 CARTON (0280-1200-20) / 20 TABLET, FILM COATED in 1 BOTTLE | 2014-09-09 | Active |
| 00280-1200-40 | 1 BOTTLE in 1 CARTON (0280-1200-40) / 40 TABLET, FILM COATED in 1 BOTTLE | 2014-09-09 | Active |
| 00280-1200-80 | 1 BOTTLE in 1 CARTON (0280-1200-80) / 80 TABLET, FILM COATED in 1 BOTTLE | 2014-09-09 | Active |
Pack size FAQ
What quantity is in NDC 00280-1200-03?
What is the difference between NDC 00280-1200-03 and NDC 00280-1200-02?
What NDC number is used to bill for this package of Aleve PM DIPHENHYDRAMINE HYDROCHLORIDE and NAPROXEN SODIUM 25 mg; 220 mg Tablet, Film Coated?
🧭 About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
Questions about this listing
Why is there no price listed?
Is the NDC printed on the package the same as the 11-digit billing NDC?
What do the three segments of this NDC mean?
Is this package still being marketed?
Does this product come in other package sizes?
Who lists this product with the FDA?
Do I need a prescription for this product?
Where does this data come from?
📄 FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses for relief of occasional sleeplessness when associated with minor aches and pains helps you fall asleep and stay asleep
⏱️ Dosage and Administration ▾
Directions do not take more than directed drink a full glass of water with each dose adults and children 12 years and over: take 2 caplets at bedtime do not take more than 2 caplets in 24 hours if taken with food, this product may take longer to work
⚠️ Warnings ▾
Warnings Allergy alert Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning This product contains an NSAID, which may cause severe stomach bleeding.
The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Heart attack and stroke warning NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.
Do not use if you have ever had an allergic reaction to any other pain reliever/fever reducer unless you have time for a full night's sleep in children under 12 years of age right before or after heart surgery with any other product containing diphenhydramine, even one used on skin if you have sleeplessness without pain Ask a doctor before use if stomach bleeding warning applies to you you have problems or serious side effects from taking pain relievers or fever reducers you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma or had a stroke you are taking a diuretic you have a breathing problem such as emphysema or chronic bronchitis you have glaucoma you have trouble urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers, or any other sleep-aid under a doctor's care for any serious condition taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin taking any other antihistamines taking any other drug When using this product drowsiness will occur avoid alcoholic drinks do not drive a motor vehicle or operate machinery take with food or milk if stomach upset occurs Stop use and ask a doctor if you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better you have symptoms of heart problems or stroke: chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 10 days sleeplessness persists continuously for more than 2 weeks.
Insomnia may be a symptom of a serious underlying medical illness. redness or swelling is present in the painful area any new symptoms appear you have difficulty swallowing it feels like the pill is stuck in your throat If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use naproxen sodium 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away.
📦 Storage and Handling ▾
Other information read all warnings and directions before use. Keep outer carton. each caplet contains: sodium 20 mg store at 20-25°C (68-77°F) avoid high humidity and excessive heat above 40°C (104°F)
🧪 Active Ingredient ▾
Active ingredients (in each caplet) Purposes Diphenhydramine hydrochloride 25 mg Nighttime sleep-aid Naproxen sodium 220 mg (naproxen 200 mg) (NSAID) nonsteroidal anti-inflammatory drug Pain reliever
🧪 Inactive Ingredients ▾
Inactive ingredients carnauba wax, FD&C blue #2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, purified water, talc, titanium dioxide
🎯 Purpose ▾
Active ingredients (in each caplet) Purposes Diphenhydramine hydrochloride 25 mg Nighttime sleep-aid Naproxen sodium 220 mg (naproxen 200 mg) (NSAID) nonsteroidal anti-inflammatory drug Pain reliever