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Diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet — RxCUI 1550957

RxNorm drug concept · Semantic clinical drug
RxCUI 1550957 Semantic clinical drug · SCD ● Current RxNorm concept 21 FDA products 41 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1550957
Official nameDiphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet
FDA products mapped21
Package NDCs mapped41
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 25 MG / naproxen s... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet RxCUI 1550957

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 5

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Naproxen 7258
    • Diphenhydramine / naproxen 1550956
    • Diphenhydramine hydrochloride 1362
    • Naproxen sodium 142442
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Aleve PM 1550958
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine / naproxen Oral Tablet 1550955
    • Diphenhydramine hydrochloride / naproxen sodium Oral Tablet 2648267
    • Diphenhydramine / naproxen Oral Product 1550953
    • Diphenhydramine / naproxen Pill 1550954
    • Diphenhydramine hydrochloride / naproxen sodium Oral Product 2661440
    • Diphenhydramine hydrochloride / naproxen sodium Pill 2662621
    • Diphenhydramine / naproxen Oral Tablet [Aleve PM] 1550960
    • Diphenhydramine hydrochloride / naproxen sodium Oral Tablet [Aleve PM] 2657846
    • +5 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 18 of 23 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Diphenhydramine hydrochloride 25 MG SCDC · 901813
  • Naproxen sodium 220 MG SCDC · 849573
  • Diphenhydramine / naproxen Oral Tablet SCDF · 1550955
  • Diphenhydramine hydrochloride / naproxen sodium Oral Tablet SCDFP · 2648267
  • Diphenhydramine / naproxen Oral Product SCDG · 1550953
  • Diphenhydramine / naproxen Pill SCDG · 1550954
  • Diphenhydramine hydrochloride / naproxen sodium Oral Product SCDGP · 2661440
  • Diphenhydramine hydrochloride / naproxen sodium Pill SCDGP · 2662621

Brand-Name Concepts

  • Diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [Aleve PM] SBD · 1550963
  • Diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG [Aleve PM] SBDC · 1550959
  • Diphenhydramine / naproxen Oral Tablet [Aleve PM] SBDF · 1550960
  • Diphenhydramine hydrochloride / naproxen sodium Oral Tablet [Aleve PM] SBDFP · 2657846
  • Aleve PM Oral Product SBDG · 1550961
  • Aleve PM Pill SBDG · 1550962
  • Aleve PM BN · 1550958

📦 FDA Products & Package NDCs

21 products · 41 package NDCs
41 package NDCs map to RxCUI 1550957 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00113-8264-06 1 BOTTLE in 1 CARTON (0113-8264-06) / 160 TABLET, FILM COAT... good sense naproxen sodium L. Perrigo Company 2026-02-26
00113-8264-60 1 BOTTLE in 1 CARTON (0113-8264-60) / 20 TABLET, FILM COATE... good sense naproxen sodium L. Perrigo Company 2018-12-28
00113-8264-71 1 BOTTLE in 1 CARTON (0113-8264-71) / 50 TABLET, FILM COATE... good sense naproxen sodium L. Perrigo Company 2022-03-14
00280-1200-01 1 BOTTLE in 1 CARTON (0280-1200-01) / 120 TABLET, FILM COAT... Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-02 2 TABLET, FILM COATED in 1 POUCH (0280-1200-02) Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-03 160 TABLET, FILM COATED in 1 BOTTLE (0280-1200-03) Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-04 1 BOTTLE in 1 CARTON (0280-1200-04) / 40 TABLET, FILM COATE... Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-05 80 TABLET, FILM COATED in 1 BOTTLE (0280-1200-05) Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-08 1 BOTTLE in 1 CARTON (0280-1200-08) / 250 TABLET, FILM COAT... Aleve PM Bayer HealthCare LLC. 2021-07-01
00280-1200-20 1 BOTTLE in 1 CARTON (0280-1200-20) / 20 TABLET, FILM COATE... Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-40 1 BOTTLE in 1 CARTON (0280-1200-40) / 40 TABLET, FILM COATE... Aleve PM Bayer HealthCare LLC. 2014-09-09
00280-1200-80 1 BOTTLE in 1 CARTON (0280-1200-80) / 80 TABLET, FILM COATE... Aleve PM Bayer HealthCare LLC. 2014-09-09
00363-2264-27 1 BOTTLE in 1 CARTON (0363-2264-27) / 80 TABLET, FILM COATE... ALL NIGHT PAIN RELIEF PM Walgreen Company 2026-04-27
11673-0687-27 1 BOTTLE in 1 CARTON (11673-687-27) / 80 TABLET, FILM COATE... up and up naproxen sodium pm Target Corporation 2022-01-25
11673-0819-08 80 TABLET in 1 BOTTLE (11673-819-08) Naproxen Sodium and Diphenhydramine HCL TARGET CORPORATION 2024-03-01
21130-0639-71 1 BOTTLE in 1 CARTON (21130-639-71) / 50 TABLET, FILM COATE... NAPROXEN SODIUM PM Safeway 2025-03-13
21130-0814-05 50 TABLET in 1 BOTTLE (21130-814-05) Naproxen Sodium Diphenhydramine Hydrochloride SAFEWAY 2023-06-30
30142-0753-27 80 TABLET in 1 BOTTLE (30142-753-27) naproxen sodium pm Kroger Company 2019-06-20
36800-0264-27 1 BOTTLE in 1 CARTON (36800-264-27) / 80 TABLET, FILM COATE... topcare all night pain relief pm Topco Associates LLC 2019-08-12
36800-0264-60 1 BOTTLE in 1 CARTON (36800-264-60) / 20 TABLET, FILM COATE... topcare all night pain relief pm Topco Associates LLC 2019-08-08
37808-0264-27 1 BOTTLE in 1 CARTON (37808-264-27) / 80 TABLET, FILM COATE... naproxen sodium pm H E B 2020-10-13
37808-0264-60 1 BOTTLE in 1 CARTON (37808-264-60) / 20 TABLET, FILM COATE... naproxen sodium pm H E B 2020-10-13
41163-0593-71 1 BOTTLE in 1 CARTON (41163-593-71) / 50 TABLET, FILM COATE... equaline naproxen sodium pm United Natural Foods, Inc. dba UNFI 2022-03-25
41250-0526-27 1 BOTTLE in 1 CARTON (41250-526-27) / 80 TABLET, FILM COATE... naproxen sodium pm Meijer Distribution Inc 2020-01-21
41250-0526-60 1 BOTTLE in 1 CARTON (41250-526-60) / 20 TABLET, FILM COATE... naproxen sodium pm Meijer Distribution Inc 2020-01-14
41520-0264-27 1 BOTTLE in 1 CARTON (41520-264-27) / 80 TABLET, FILM COATE... careone naproxen sodium pm American Sales Company 2020-02-25
41520-0264-60 1 BOTTLE in 1 CARTON (41520-264-60) / 20 TABLET, FILM COATE... careone naproxen sodium pm American Sales Company 2020-02-25
55910-0858-27 1 BOTTLE in 1 CARTON (55910-858-27) / 80 TABLET, FILM COATE... dg health naproxen sodium pm Dolgencorp Inc 2020-07-10
62011-0396-01 1 BOTTLE, PLASTIC in 1 BOX (62011-0396-1) / 20 TABLET in 1... Naproxen Sodium PM Strategic Sourcing Services LLC 2019-01-31
62207-0814-38 37500 TABLET, FILM COATED in 1 POUCH (62207-814-38) Naproxen Sodium and Diphenhydramine HCl Granules India Ltd 2021-02-20
62207-0814-39 7500 TABLET, FILM COATED in 1 POUCH (62207-814-39) Naproxen Sodium and Diphenhydramine HCl Granules India Ltd 2021-02-20
62207-0814-47 500 TABLET, FILM COATED in 1 BOTTLE (62207-814-47) Naproxen Sodium and Diphenhydramine HCl Granules India Ltd 2021-02-20
62207-0814-95 1 BOTTLE in 1 CARTON (62207-814-95) / 20 TABLET, FILM COATE... Naproxen Sodium and Diphenhydramine HCl Granules India Ltd 2021-02-20
69238-1422-02 1 BOTTLE in 1 CARTON (69238-1422-2) / 20 TABLET, FILM COATE... Naproxen Sodium and Diphenhydramine HCl Amneal Pharmaceuticals NY LLC 2018-10-23
69238-1422-04 1 BOTTLE in 1 CARTON (69238-1422-4) / 40 TABLET, FILM COATE... Naproxen Sodium and Diphenhydramine HCl Amneal Pharmaceuticals NY LLC 2018-10-23
69238-1422-06 1 BOTTLE in 1 CARTON (69238-1422-6) / 160 TABLET, FILM COAT... Naproxen Sodium and Diphenhydramine HCl Amneal Pharmaceuticals NY LLC 2018-10-23
69238-1422-08 1 BOTTLE in 1 CARTON (69238-1422-8) / 80 TABLET, FILM COATE... Naproxen Sodium and Diphenhydramine HCl Amneal Pharmaceuticals NY LLC 2018-10-23
69842-0328-02 20 TABLET, FILM COATED in 1 BOTTLE (69842-328-02) Naproxen Sodium Diphenhydramine HCl CVS PHARMACY, INC 2021-05-14
70677-0064-01 1 BOTTLE, PLASTIC in 1 BOX (70677-0064-1) / 20 TABLET in 1... Naproxen Sodium PM Strategic Sourcing Services LLC 2018-12-31
72288-0310-06 1 BOTTLE in 1 CARTON (72288-310-06) / 160 TABLET, FILM COAT... basic care naproxen sodium pm Amazon.com Services LLC 2021-08-10
79903-0204-20 20 TABLET in 1 BOTTLE (79903-204-20) Naproxen Sodium Diphenhydramine HCL Walmart 2023-12-14
Observed labelers: Bayer HealthCare LLC. (9) · Amneal Pharmaceuticals NY LLC (4) · Granules India Ltd (4) · L. Perrigo Company (3) · American Sales Company (2) · H E B (2) · +12 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.