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Naproxen Sodium and Diphenhydramine HCL 25 mg; 220 mg Tablet, 80-count — NDC 11673-819-08 (Billing 11673-0819-08)

by TARGET CORPORATION · 80 TABLET in 1 BOTTLE

This is a package of 80 tablets of Naproxen Sodium and Diphenhydramine HCL 25 mg; 220 mg Tablet from TARGET CORPORATION, marketed since Mar 2024 and currently FDA-listed. It is this product's only package size.

NDC 11673-0819-08
🏷️ FDA NDC (as labeled) 11673-819-08 billing pads the product segment with a zero
OTC Generic On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 11673-819-08
Product NDC 11673-819
11-digit billing NDC 11673081908
RxCUI 1550957
UNII TC2D6JAD40, 9TN87S3A3C
Application # ANDA213663
SPL Set ID fe82699d-fdc2-038e-e053-6294a90a606c
Established class (EPC) Anti-Inflammatory Agents; Histamine-1 Receptor Antagonist; Nonsteroidal Anti-inflammatory Drug
Mechanism of action Cyclooxygenase Inhibitors; Histamine H1 Receptor Antagonists
Chemical class Non-Steroidal
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2024-03-01
Route ORAL
Dosage form TABLET
Substance DIPHENHYDRAMINE HYDROCHLORIDE; NAPROXEN SODIUM
Quick answers
  • RxCUI (RxNorm): 1550957
Why two NDCs? The FDA registers this code as 11673-819-08 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 11673-0819-08. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
11673-0819-08 You're viewing this Main listing 80 TABLET in 1 BOTTLE 2024-03-01 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
good sense naproxen sodium 25 mg/1; 220 mg 00113-8264-58 L. 40 tablets — — Discontinued —
Aleve PM 25 mg/1; 220 mg 00280-1200-01 Bayer 120 tablets — — FDA listed —
All Night Pain Relief Pm 25 mg/1; 220 mg 00363-2264-27 Walgreen 80 tablets — — FDA listed —
up and up naproxen sodium pm 25 mg/1; 220 mg 11673-0687-27 Target 80 tablets — — FDA listed —
Naproxen Sodium and Diphenhydramine HCL 25 mg/1; 220 mgthis 11673-0819-08 TARGET 80 tablets — — FDA listed —
Naproxen Sodium Pm 25 mg/1; 220 mg 21130-0639-71 Safeway 50 tablets — — FDA listed —
Naproxen Sodium Diphenhydramine Hydrochloride 220 mg/1; 25 mg 21130-0814-05 SAFEWAY 50 tablets — — FDA listed —
naproxen sodium pm 25 mg/1; 220 mg 30142-0383-60 Kroger 20 tablets — — Discontinued —
naproxen sodium pm 25 mg/1; 220 mg 30142-0753-27 Kroger 80 tablets — — FDA listed —
topcare all night pain relief pm 25 mg/1; 220 mg 36800-0264-27 Topco 80 tablets — — FDA listed —
naproxen sodium pm 25 mg/1; 220 mg 37808-0264-27 H 80 tablets — — FDA listed —
equaline naproxen sodium pm 25 mg/1; 220 mg 41163-0593-58 United 40 tablets — — Discontinued —
naproxen sodium pm 25 mg/1; 220 mg 41250-0526-27 Meijer 80 tablets — — FDA listed —
careone naproxen sodium pm 25 mg/1; 220 mg 41520-0264-27 American 80 tablets — — FDA listed —
dg health naproxen sodium pm 25 mg/1; 220 mg 55910-0858-27 Dolgencorp 80 tablets — — FDA listed —
Naproxen Sodium PM 220 mg/1; 25 mg 62011-0396-01 Strategic 20 tablets — — Discontinued —
Naproxen Sodium and Diphenhydramine HCl 220 mg/1; 25 mg 62207-0814-38 Granules 37500 tablets — — FDA listed —
Naproxen Sodium and Diphenhydramine HCl 220 mg/1; 25 mg 69238-1422-02 Amneal 20 tablets — — FDA listed —
Naproxen Sodium Diphenhydramine HCl 220 mg/1; 25 mg 69842-0328-02 CVS 20 tablets — — FDA listed —
Naproxen Sodium PM 220 mg/1; 25 mg 70677-0064-01 Strategic 20 tablets — — FDA listed —
basic care naproxen sodium pm 25 mg/1; 220 mg 72288-0310-06 Amazon.com 160 tablets — — FDA listed —
Naproxen Sodium Diphenhydramine HCL 25 mg/1; 220 mg 79903-0204-20 Walmart 20 tablets — — FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2024
On the market since
Mar 2024
📍
2026
Currently FDA-listed
2 years listed
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerTARGET CORPORATION
Application holderGRANULES INDIA LTD
FDA applicationANDA213663 (ANDA)
Labeler code11673
First marketedMar 2024
Product typeHuman Otc Drug
Portfolio408 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 22 words ▾

Uses • for relief of occasional sleeplessness when associated with minor aches and pains • helps you fall asleep and stay asleep

⏱️ Dosage and Administration 54 words ▾

Directions • do not take more than directed • drink a full glass of water with each dose • adults and children 12 years and over: take 2 caplets at bedtime • do not take more than 2 caplets in 24 hours • if taken with food, this product may take longer to work

⚠️ Warnings 165 words ▾

Allergy alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: • hives • facial swelling • asthma (wheezing) • shock • skin reddening • rash • blisters If an allergic reaction occurs, stop use and seek medical help right away.

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you: • are age 60 or older • have had stomach ulcers or bleeding problems • take a blood thinning (anticoagulant) or steroid drug • take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) • have 3 or more alcoholic drinks every day while using this product • take more or for a longer time than directed

Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if use more than directed or for longer than directed.

📦 Storage and Handling 39 words ▾

Other information • each caplet contains: sodium 20 mg • read all warnings and directions before use. keep outer carton. • store at 20 to 25°C (68 to 77°F) • avoid high humidity and excessive heat above 40°C (104°F)

🧪 Active Ingredient 21 words ▾

Active ingredients (in each caplet) Diphenhydramine Hydrochloride 25 mg Naproxen Sodium 220 mg (naproxen 200 mg) (NSAID)* * nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 18 words ▾

Inactive ingredients FD&C blue 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide.

🎯 Purpose 6 words ▾

Purposes Nighttime sleep aid Pain reliever

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by TARGET CORPORATION. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
TARGET CORPORATION is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 11673-0814-00 · TARGET 11673-0823-02 · TARGET →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.