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Differin Epiduo Adapalene and Benzoyl Peroxide 1 mg/g; 25 mg/g Gel — NDC 00299-4908-40 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Differin Epiduo Adapalene and Benzoyl Peroxide 1 mg/g; 25 mg/g Gel — NDC 0299-4908-40 (Billing 00299-4908-40)

by Galderma Laboratories, L.P. · 1 BOTTLE, PUMP in 1 CARTON / 45 g in 1 BOTTLE, PUMP

This is a package of Differin Epiduo Adapalene and Benzoyl Peroxide 1 mg/g; 25 mg/g Gel from Galderma Laboratories, L.P., marketed since May 2026 and currently FDA-listed.

NDC 00299-4908-40
🏷️ FDA NDC (as labeled) 0299-4908-40 billing pads the labeler segment with a zero
This package
Contains45 g in 1 bottle, pump Pack sizes3 compare ↓
Product page 00299-4908-00 Also comes in: 15 g 0299-4908-10 2 g 0299-4908-00
OTC Brand On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 0299-4908-40
Product NDC 0299-4908
11-digit billing NDC 00299490840
RxCUI 829539, 2743622
UNII 1L4806J2QF, W9WZN9A0GM
Application # NDA220736
SPL Set ID ae3f8cd9-9046-4b69-b80f-3e9d4468ba7f
Established class (EPC) Retinoid
Chemical class Retinoids
DEA schedule Non-controlled
Marketing category NDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2026-05-22
Route TOPICAL
Dosage form GEL
Substance ADAPALENE; BENZOYL PEROXIDE
Quick answers
  • RxCUI (RxNorm): 829539
Why two NDCs? The FDA registers this code as 0299-4908-40 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00299-4908-40. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Peroxides class.

Drug family (ATC) Peroxides
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📖 What it is MedlinePlus · NLM

Adapalene is used to treat acne in adults and children 12 years of and older. Adapalene is in a class of medications called retinoid-like compounds. It works by stopping pimples from forming under the surface of the skin.

Read the full MedlinePlus article ↗

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 15 g 2 g
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
00299-4908-00 0299-4908-00 Main listing 2 g in 1 TUBE Sample 2026-05-22 — Active
00299-4908-10 0299-4908-10 1 BOTTLE, PUMP in 1 CARTON / 15 g in 1 BOTTLE, PUMP 2026-05-22 — Active
00299-4908-40 You're viewing this 1 BOTTLE, PUMP in 1 CARTON / 45 g in 1 BOTTLE, PUMP 2026-05-22 — Active

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 1 bottle, pump in 1 carton / 45 g in 1 bottle, pump.
What NDC number is used to bill for this package of Differin Epiduo Adapalene and Benzoyl Peroxide 1 mg/g; 25 mg/g Gel?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5% 1 mg/g; 25 mg/g 21922-0052-50 Encube 1 bottle $0.368 AB Availability likely —
adapalene and benzoyl peroxide .1 g/100g; 2.5 g/100g 45802-0846-01 Padagis 45 g $0.368 AB Availability likely —
ADAPALENE and BENZOYL PEROXIDE 1 mg/g; 25 mg/g 51672-1364-03 Sun 1 bottle $0.368 AB Availability likely —
adapalene and benzoyl peroxide 1 mg/g; 25 mg/g 68462-0301-47 Glenmark 1 bottle $0.368 AB Availability likely —
Differin Epiduo 1 mg/g; 25 mg/gthis 00299-4908-40 Galderma 1 bottle — — FDA listed —
adapalene and benzoyl peroxide .1 g/100g; 2.5 g/100g 63629-8607-01 Bryant 1 bottle — AB FDA listed —
adapalene and benzoyl peroxide .1 g/100g; 2.5 g/100g 72162-1430-02 Bryant 45 g — AB FDA listed —
Adapalene and Benzoyl Peroxide Gel, 0.1%/2.5% 1 mg/g; 25 mg/g 72162-2296-02 Bryant 1 bottle — AB FDA listed —
About this product: this is the brand-name version. FDA-approved generic versions are listed, and recent pricing/market data suggests they may be available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2026
On the market since
May 2026
📍
2026
Currently FDA-listed
listed with the FDA
🔓
·
Generic versions listed
see equivalents
✅Generic appears available

FDA-approved generic versions are listed, and recent pricing/market data suggests they may be available — see Therapeutic equivalents.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 5F4963KLHS
    A synthetic polymer created from acrylamide and sodium acryloyldimethyltaurate that thickens and stabilizes liquid or semi-solid formulations. It helps maintain consistent texture and prevents separation of ingredients in creams, gels, and lotions.
  • UNII F05Q2T2JA0
    Docusate sodium is a stool softener compound that helps medicines dissolve and move through the digestive tract. It acts as a surfactant, reducing surface tension in the intestines, and also serves as a wetting agent in tablet formulations.
  • UNII 7FLD91C86K
    Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 918X1OUF1E
    Isohexadecane is a synthetic hydrocarbon oil used as an emollient and solvent in topical medicines. It helps dissolve active ingredients and improves spreadability and absorption through the skin.
  • UNII 1S66E28KXA
    Poloxamer 124 is a synthetic polymer that acts as a surfactant and solubilizer in medicines. It helps dissolve and stabilize active ingredients, particularly in liquid formulations and gels.
  • UNII 6OZP39ZG8H
    Polysorbate 80 is a synthetic emulsifier derived from sorbitol and oleic acid. It helps mix oil and water-based ingredients together in medications and improves how the product disperses in the body.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII 06XEA2VD56
    Sorbitan oleate is an emulsifier derived from sorbitol and oleic acid. It helps mix oil and water-based ingredients together and keeps them from separating in the medicine.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

10 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesacrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water, and sorbitan oleate

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerGalderma Laboratories, L.P.
Application holderGALDERMA LABORATORIES LP
FDA applicationNDA220736 (NDA)
Labeler code00299
First marketedMay 2026
Product typeHuman Otc Drug
Portfolio50 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Very long sections are excerpted here and marked; the full text is on DailyMed (linked in the sources below). Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 💬 Information for Patients 📄 Do Not Use 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 6 words ▾

Use For the treatment of acne

⏱️ Dosage and Administration 118 words ▾

Directions Adults and children 12 years of age and older: use once daily clean the skin gently and pat dry before applying the product cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. applying more than directed will not provide faster or better results, but may worsen skin irritation. if going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of both products and ask a doctor.

Children under 12 years of age: do not use Other information store at 20°C to 25°C (68°F to 77°F) protect from freezing protect from light and keep away from heat

⚠️ Warnings 5 words ▾

Warnings For external use only

🧪 Active Ingredient 14 words ▾

Drug Facts Active ingredient Adapalene 0.1% (retinoid)* *read consumer information leaflet Benzoyl Peroxide 2.5%

🧪 Inactive Ingredients 22 words ▾

Inactive Ingredients acrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water, and sorbitan oleate

🎯 Purpose 5 words ▾

Purpose Acne treatment Acne treatment

💬 Information for Patients ~3 min read ▾

Patient Leaflet DIFFERIN® EPIDUO ACNE GEL ADAPALENE 0.1% and BENZOYL PEROXIDE 2.5% GEL ACNE TREATMENT Frequently Asked Questions What is Differin Epiduo Acne Gel and what is it used for? Differin Epiduo Acne Gel is a topical medication used for the treatment of acne in people age 12 years and older. What should I know before using Differin Epiduo Acne Gel?

If pregnant or breast-feeding, ask a doctor before use. Some other retinoid drugs have been shown to cause birth defects. There is no specific evidence that Differin Epiduo Acne Gel causes birth defects in humans when used topically as directed.

Do not use Differin Epiduo Acne Gel if you are allergic to adapalene or any of the ingredients in this product, if you have very sensitive skin or if are you sensitive to benzoyl peroxide. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

How often do I apply Differin Epiduo Acne Gel? Apply Differin Epiduo Acne Gel only one time a day and try to apply the product at the same time each day. How do I apply Differin Epiduo Acne Gel?

Gently clean the affected areas using a mild (non-irritating) cleanser and pat dry. Apply Differin Epiduo Acne Gel as a thin layer to the affected areas of the skin only one time a day . For example, if you get acne on the face, clean, dry and apply the product to the entire face.

Differin Epiduo Acne Gel is not a spot treatment and should not be used to treat a single pimple. Avoid contact with eyes, lips and mouth. If contact occurs, immediately flush the area with water.

Do not apply to damaged skin (cuts, abrasions, eczema, or sunburn). Wash hands after use. How long will it take for Differin Epiduo Acne Gel to work?

It may take up to 3 months of daily use for results to appear. Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation.

What do I do if I need to be in the sun? When possible, limit sun exposure, including light from tanning beds. When going outdoors, use a sunscreen as labeled.

Your skin may be more sensitive while using Differin Epiduo Acne Gel. If you use Differin Epiduo Acne Gel during the day, allow it to dry before applying sunscreen. DIFFERIN® EPIDUO ACNE GEL ADAPALENE 0.1% AND BENZOYL PEROXIDE 2.5% GEL ACNE TREATMENT Frequently Asked Questions (Continued) Can I use a moisturizer if my skin is dry?

Yes, use of a moisturizer may help decrease dryness and other signs of irritation. Avoid products that may dry or irritate your skin such as harsh soaps, astringents, cosmetics that have strong skin-drying effects and products containing high levels of alcohol. When is my skin most likely to become irritated?

And what do I do? Irritation (redness, itching, dryness, burning) is more likely to occur: In the first few weeks of use. if using abrasive skin cleansers, products with drying effects or more than one topical acne medication at a time. You may want to delay starting Differin Epiduo Acne Gel until any irritation from using the other product(s) has gone away. in extreme weather such as wind and cold.

Moisturizers may be used. Irritation usually lessens after 4 weeks of continued use. What do I do if my skin becomes severely irritated?

If irritation gets wors, stop use and ask a doctor before using Differin Epiduo Acne Gel again. Can I remove unwanted facial hair by waxing while using Differin Epiduo Acne Gel? Do not use wax to remove hair in areas where Differin Epiduo Gel has been applied because it may worsen skin irritation.

What ingredients are used in Differin Epiduo Acne Gel? Differin Epiduo Acne Gel contains: The active ingredients are adapalene 0.1% and benzoyl peroxide 2.5%. The other ingredients are: acrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water, and sorbitan oleate.

How should I store this Differin Epiduo Ac… [Excerpted — this section continues on DailyMed.]

📄 Do Not Use 37 words ▾

Do not use on damaged skin (cuts, abrasions, eczema, sunburn) if you are allergic to adapalene or any of the ingredients in this product. If you have very sensitive skin If you are sensitive to benzoyl peroxide

📄 Ask a Doctor or Pharmacist Before Use If 30 words ▾

Ask a doctor or pharmacist before use if you use any other acne medications have any other skin or medical conditions If pregnant or breast-feeding, ask a doctor before use.

📄 When Using This Product 157 words ▾

When using this product limit sun exposure, including light from tanning beds, and use sunscreen when going outdoors do not wax to remove hair in areas where the product has been applied avoid contact with hair and dyed fabrics, which may be bleached by this product during the early weeks of use, your acne may appear to worsen before it improves (this is normal) irritation (redness, itching, dryness, burning, peeling or possible swelling) is more likely to occur: in the first four weeks of use if using more than one topical acne medication at a time If irritation occurs, it may be reduced: by using the product less frequently by using moisturizer by using only one topical acne medication at a time it may take up to 3 months of once daily use to see results avoid product contact with eyes, lips, and mouth.

If contact occurs, immediately flush the area with water. wash hands after use

📄 Stop Use and Ask a Doctor If 73 words ▾

Stop use and ask doctor if you become pregnant, or are planning to become pregnant, while using the product you have symptoms of an allergic reaction (such as itching, rash, hives, swelling of the lips, eyelids, and shortness of breath) irritation gets worse you see no improvement after 3 months of once daily use Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 2 words ▾

Questions? 1-866-735-4137

📄 Package Label / Principal Display Panel 128 words ▾

PRINCIPAL DISPLAY PANEL - 45g Carton (Pump) CONTAINS 2 MEDICINES DIFFERIN® EPIDUO ACNE GEL ADAPALENE 0.1% and BENZOYL PEROXIDE 2.5% GEL ACNE TREATMENT DUAL ACTION ACNE 2 in 1 CLEARING GEL Combines two acne-clearing ingredients Previously available only by prescription Dermatologist developed and tested Once daily topical acne treatment* * Read consumer information leaflet before use NET WT

1.6OZ (45 g) Easy pump! First FDA-approved over-the-counter dual active ingredient acne treatment. Read carton and enclosed consumer information leaflet before using this product.

Keep this carton and consumer information leaflet. They contain important information. ACTUAL SIZE Water-based, oil-free gel Fragrance free GALDERMA Distributed by: Galderma Laboratories, L.P.

Fort Worth, TX 76177 USA All trademarks are the property of their respective owners. Made in Canada www.differin.com NDC: 0299-4908-40 PXXXXX-X

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Galderma Laboratories, L.P.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 1 bottle (00299-4908-10), 2 g (00299-4908-00). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Galderma Laboratories, L.P. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 00299-4611-00 · Galderma 00299-4910-00 · Galderma →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.