anti diarrheal plus anti gas loperamide hydrochloride, simethicone 2 mg; 125 mg Tablet, 42-count — NDC 41250-0375-55 package photo

anti diarrheal plus anti gas loperamide hydrochloride, simethicone 2 mg; 125 mg Tablet, 42-count

by Meijer Distribution Inc · 1 BOTTLE in 1 CARTON (41250-375-55) / 42 TABLET in 1 BOTTLE
NDC 41250-0375-55
🏷️ FDA NDC (as labeled) 41250-375-55 billing pads the product segment with a zero
This package
Contains42-count Pack sizes4 compare ↓
OTC Generic Discontinued Non-controlled ⚠ Discontinued by firm
🗂️ Data synced Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
⚠️
Excluded from the active FDA NDC Directory. The labeler reported this product as discontinued, so it is excluded from the active NDC Directory. A label may still appear on DailyMed, but the NDC is no longer in the current FDA NDC Directory. Search the FDA NDC Directory ↗

🆔 Identity & classification

FDA NDC (as labeled) 41250-375-55
Product NDC 41250-375
11-digit billing NDC 41250037555
RxCUI 978001
UNII 77TI35393C, 92RU3N3Y1O
Application # ANDA209837
SPL Set ID e2c9a752-618a-4e34-89a5-671aab4013ac
Physiologic effect Skin Barrier Activity
DEA schedule Non-controlled
Marketing category ANDA
Marketing status Discontinued
FDA listing status Discontinued by firm
Marketing start 2018-10-16
Route ORAL
Dosage form TABLET
Substance LOPERAMIDE HYDROCHLORIDE; DIMETHICONE
Why two NDCs? The FDA registers this code as 41250-375-55 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 41250-0375-55. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Opioid Agonist class.

Pharmacologic class Opioid Agonist
Drug family (ATC) Antipropulsives
How it works Opioid Agonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerMeijer Distribution Inc
Application holderPERRIGO R AND D CO
FDA applicationANDA209837 (ANDA)
Labeler code41250
First marketedOct 2018
Product typeHuman Otc Drug
Portfolio244 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

📖 What it is MedlinePlus · NLM

Nonprescription (over-the-counter) loperamide is used to control acute diarrhea (loose stools that come on suddenly and usually lasts less than 2 weeks), including travelers' diarrhea. Prescription loperamide is also used to control acute diarrhea and also ongoing diarrhea associated with inflammatory bowel disease (IBD; condition in which the lining of all or part of the intestine is swollen, irritated, or has sores). Prescription loperamide is also used to reduce the amount of fluid in people with ileostomies (surgery to create an opening for waste to leave the body through the abdomen). Lop...

Read the full MedlinePlus article ↗
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 23OV73Q5G9
    Acesulfame potassium is an artificial sweetener that tastes about 200 times sweeter than sugar. It's added to medicines to improve taste without adding calories or affecting blood sugar.
  • UNII L11K75P92J
    A mineral salt made from calcium and phosphate. It acts as a filler and binder in tablets to add bulk and help hold the medicine together in solid form.
  • UNII M28OL1HH48
    Croscarmellose sodium is a plant-based substance derived from cellulose. It acts as a disintegrant, helping tablets and capsules break down quickly in the digestive system so the medicine can be absorbed.
  • UNII 7CVR7L4A2D
    A starch-derived carbohydrate produced by breaking down corn, potato, or tapioca starch. It functions as a filler and binder to give the medicine bulk and texture, and sometimes as a mild sweetener or texture enhancer in powders and tablets.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII ETJ7Z6XBU4
    Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
  • UNII 4ELV7Z65AP
    Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesacesulfame potassium, croscarmellose sodium, dibasic calcium phosphate, maltodextrin, microcrystalline cellulose, natural and artificial flavor, propylene glycol, stearic acid

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMedingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 18 tablets 24 tablets 30 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
good sense anti diarrheal anti gas 2 mg/1; 125 mg 00113-0087-53 L. 12 tablets $0.287 Availability likely
good neighbor pharmacy anti diarrheal anti gas 2 mg/1; 125 mg 46122-0620-62 Amerisource 24 tablets $0.287 Availability likely
foster and thrive anti diarrheal anti gas 2 mg/1; 125 mg 70677-1105-01 Strategic 12 tablets $0.287 Availability likely
Good Sense Anti Diarrheal Anti Gas 2 mg/1; 125 mg 00113-1087-89 L. 18 tablets FDA listed
anti diarrheal and anti gas 2 mg/1; 125 mg 00363-1830-53 Walgreen 12 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 00363-9606-75 WALGREEN 12 tablets FDA listed
up and up anti diarrheal anti gas 2 mg/1; 125 mg 11673-0646-62 Target 24 tablets FDA listed
signature care anti diarrheal anti gas 2 mg/1; 125 mg 21130-0183-62 Safeway 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 21130-0222-24 Better 24 tablets FDA listed
Anti Diarrheal Anti Gas 2 mg/1; 125 mg 30142-0581-53 Kroger 12 tablets FDA listed
anti diarrheal anti gas 2 mg/1; 125 mg 37808-0714-53 H 12 tablets FDA listed
equaline anti diarrheal plus anti gas 2 mg/1; 125 mg 41163-0553-89 United 18 tablets FDA listed
anti diarrheal plus anti gas 2 mg/1; 125 mgthis 41250-0375-55 Meijer 42 tablets Discontinued
CareOne Diarrhea and Gas Control 2 mg/1; 125 mg 41520-0772-53 American 12 tablets FDA listed
anti diarrheal anti gas 2 mg/1; 125 mg 42507-0699-53 HyVee 12 tablets FDA listed
IMODIUM Multi-Symptom Relief 2 mg/1; 125 mg 50580-0338-12 Kenvue 12 tablets FDA listed
Loperamide HCl and Simethicone 2 mg/1; 125 mg 51660-0069-06 Ohm 6 tablets FDA listed
Loperamide Hydrochloride, Simethicone 2 mg/1; 125 mg 53041-0263-50 Guardian 6 tablets FDA listed
Anti-Diarrheal/Anti-Gas 2 mg/1; 125 mg 53943-0263-33 Discount 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 55319-0052-75 Family 12 tablets FDA listed
dg health anti diarrheal anti gas 2 mg/1; 125 mg 55910-0383-53 Dolgencorp, 12 tablets FDA listed
antidiarrheal multi symptom relief 125 mg/1; 2 mg 56062-0511-62 Publix 24 tablets Discontinued
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 58602-0815-74 Aurohealth 6 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 58602-0868-76 Aurohealth 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 58602-0869-76 Aurohealth 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 62207-0739-69 Granules 12 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 69230-0325-04 Camber 4 tablets FDA listed
Anti-Diarrheal/Anti-Gas 2 mg/1; 125 mg 69256-0265-31 Harris 12 tablets FDA listed
Loperamide hydrochloride and Simethicone 2 mg/1; 125 mg 69452-0210-04 Bionpharma 6 tablets FDA listed
Loperamide hydrochloride and Simethicone 2 mg/1; 125 mg 69452-0531-12 Bionpharma 24 tablets FDA listed
anti diarrheal and anti gas 2 mg/1; 125 mg 69842-0644-53 CVS 12 tablets FDA listed
Basic Care Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 72288-0001-62 Amazon.com 24 tablets FDA listed
Anti-Diarrheal/Anti-Gas Caplets 2 mg/1; 125 mg 73581-0178-24 YYBA 24 tablets FDA listed
Anti-Diarrheal/Anti-Gas Multi-Symptom Relief 2 mg/1; 125 mg 79903-0116-33 Wal-Mart 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 79903-0223-12 WALMART 12 tablets FDA listed
Equate Anti Diarrheal Anti Gas Multi-Symptom Relief 2 mg/1; 125 mg 79903-0302-12 WALMART 12 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 80136-0384-24 NORTHEAST 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 2 mg/1; 125 mg 81522-0325-24 FSA 24 tablets FDA listed
Loperamide Hydrochloride and Simethicone 125 mg/1; 2 mg 84441-0713-10 IMO-GEN 100 tablets FDA listed
anti diarrheal anti gas 2 mg/1; 125 mg 11822-1003-01 Rite 42 tablets Discontinued
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2018
On the market since
Oct 2018
📍
2026
Currently FDA-listed
8 years listed
🔓
·
Generic on the market
this product is a generic
This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
41250-0375-55 You're viewing this 1 BOTTLE in 1 CARTON (41250-375-55) / 42 TABLET in 1 BOTTLE 2018-10-16 Discontinued by firm
41250-0375-62 24 BLISTER PACK in 1 CARTON (41250-375-62) / 1 TABLET in 1 BLISTER PACK 2020-02-03 Active
41250-0375-65 1 BOTTLE in 1 CARTON (41250-375-65) / 30 TABLET in 1 BOTTLE 2018-10-16 Discontinued by firm
41250-0375-89 18 BLISTER PACK in 1 CARTON (41250-375-89) / 1 TABLET in 1 BLISTER PACK 2018-10-16 Active

Pack size FAQ

What quantity is in NDC 41250-0375-55?
NDC 41250-0375-55 is a 42-count package — 1 bottle in 1 carton / 42 tablet in 1 bottle.
What is the difference between NDC 41250-0375-55 and NDC 41250-0375-89?
Both are anti diarrheal plus anti gas loperamide hydrochloride, simethicone 2 mg; 125 mg Tablet — the drug itself is identical. NDC 41250-0375-55 is the 42-count package, while NDC 41250-0375-89 is the 18 tablets package.
What NDC number is used to bill for this package of anti diarrheal plus anti gas loperamide hydrochloride, simethicone 2 mg; 125 mg Tablet?
Bill NDC 41250-0375-55 — the 11-digit billing format is 41250037555. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product No longer marketed (per FDA listing data)
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
What does the discontinued status mean for this NDC?
The labeler reported a marketing end date (or the listing was delisted), so this specific package is no longer actively marketed. Remaining stock may still be dispensed for a time, and the NDC stays valid for historical records and claims — but data feeds (pricing, labeling) typically stop updating for it. Other package sizes or other manufacturers' versions of the same medication may still be marketed — see the equivalents section where available.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 41250-375-55, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 41250-0375-55, written without dashes as 41250037555. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 41250-0375-55, the first segment (41250) is the labeler code FDA assigned to Meijer Distribution Inc; the middle segment (0375) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (55) identifies this exact package size and type. Together they name one specific package of one specific product.
Does this product come in other package sizes?
Yes — the FDA directory lists 3 other package presentations of this same product, including 18 tablets (41250-0375-89), 24 tablets (41250-0375-62), 30 tablets (41250-0375-65). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Meijer Distribution Inc is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage 15 words

Uses relieves symptoms of diarrhea plus bloating, pressure and cramps, commonly referred to as gas

⏱️ Dosage and Administration 163 words

Directions • drink plenty of clear fluids to help prevent dehydration caused by diarrhea • take only on an empty stomach (1 hour before or 2 hours after a meal) • take with a full (8 oz.) glass of water • find right dose on chart below. If possible, use weight to dose; otherwise, use age. adults and children 12 years and over 2 caplets after the first loose stool; 1 caplet after each subsequent loose stool; but no more than 4 caplets in 24 hours children 9-11 years (60-95 lbs) 1 caplet after the first loose stool; ½ caplet after each subsequent loose stool; but no more than 3 caplets in 24 hours children 6-8 years (48-59 lbs) 1 caplet after the first loose stool; ½ caplet after each subsequent loose stool; but no more than 2 caplets in 24 hours children 2-5 years (34 to 47 lbs) ask a doctor children under 2 years (up to 33 lbs) do not use

⚠️ Warnings 189 words

Warnings Allergy alert: Do not use if you have ever had a rash or other allergic reaction to loperamide HCl Heart alert: Taking more than directed can cause serious heart problems or death Do not use • if you have bloody or black stool • if you have difficulty swallowing Ask a doctor before use if you have • fever • mucus in the stool • a history of liver disease • a history of abnormal heart rhythm Ask a doctor or pharmacist before use if you are taking a prescription drug. Loperamide may interact with certain prescription drugs.

When using this product tiredness, drowsiness or dizziness may occur. Be careful when driving or operating machinery. Stop use and ask a doctor if • symptoms get worse • diarrhea lasts for more than 2 days • you get abdominal swelling or bulging.

These may be signs of a serious condition. • you have difficulty swallowing the caplet If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

(1-800-222-1222)

📦 Storage and Handling 40 words

Other information • each caplet contains: calcium 165 mg, sodium 3 mg • store between 20 ° -25 ° C (68 ° -77 ° F). Protect from light. • do not use if printed blister unit is broken or torn

🧪 Active Ingredient 12 words

Active ingredients (in each caplet) Loperamide HCl 2 mg Simethicone 125 mg

🧪 Inactive Ingredients 20 words

Inactive ingredients acesulfame potassium, croscarmellose sodium, dibasic calcium phosphate, maltodextrin, microcrystalline cellulose, natural and artificial flavor, propylene glycol, stearic acid

🎯 Purpose 3 words

Purposes Anti-diarrheal Anti-gas

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.