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Allergy Relief Childrens diphenhydramine HCl 12.5 mg Tablet, Chewable — NDC 46122-0425-89 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Allergy Relief Childrens diphenhydramine HCl 12.5 mg Tablet, Chewable — NDC 46122-425-89 (Billing 46122-0425-89)

by Amerisource Bergen · 4 BLISTER PACK in 1 CARTON / 5 TABLET, CHEWABLE in 1 BLISTER PACK

This is a package of Allergy Relief Childrens diphenhydramine HCl 12.5 mg Tablet, Chewable from Amerisource Bergen, marketed since Apr 2011 and currently FDA-listed, this package's marketing is listed to end Apr 2027; retail pharmacies pay about $0.1130 per unit (NADAC). It is this product's only package size.

NDC 46122-0425-89
🏷️ FDA NDC (as labeled) 46122-425-89 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 46122-425-89 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
46122 labeler · 425 product · 89 package
Package marketed since
Apr 25, 2011
Package marketing ended
Apr 30, 2027
Sample package
No — commercial package
Barcode (UPC)
0087701429644
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 46122-425-89
Product NDC 46122-425
11-digit billing NDC 46122042589
NCPDP billing unit EA — each (per item)
RxCUI 1049900
UNII TC2D6JAD40
UPC 0087701429644
Application # M012
SPL Set ID 934c7b91-3cba-47f0-8efa-77216f3f15c4
Established class (EPC) Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2011-04-25
Marketing end 2027-04-30
Route ORAL
Dosage form TABLET, CHEWABLE
Substance DIPHENHYDRAMINE HYDROCHLORIDE

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 41200030100510
GPI class GNP Allergy Relief
GCN Seq No 023635
GCN 46060
HICL code 004480
Ingredient (HICL) Diphenhydramine Hcl
HIC1 code Z
Therapeutic class — broad (HIC1) Body As A Whole
HIC2 code Z2
Therapeutic class — intermediate (HIC2) Antihistamines, Antiserotonins, Immunosuppressants
HIC3 code Z2P
Therapeutic class — specific (HIC3) Antihistamines - 1St Generation
AHFS code 04:04.00.00
AHFS class First Generation Antihistamines
FDB label name CHLD ALLRGY RLF 12.5MG CHEW TB
FDB brand name Children's Allergy Relief
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 023635
  • GCN: 46060
  • GPI-14 (Medi-Span): 41200030100510
  • HICL (First Databank): 004480
  • AHFS class code: 04:04.00.00
  • RxCUI (RxNorm): 1049900
Why two NDCs? The FDA registers this code as 46122-425-89 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 46122-0425-89. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name CHLD ALLRGY RLF 12.5MG CHEW TB Ingredient Diphenhydramine Hcl
📗 Our plain-language guide HelloPharmacist
  • Oral products temporarily relieve hay fever and other upper respiratory allergy symptoms like runny nose, sneezing and itchy, watery eyes. They also ease runny nose and sneezing fr...
  • Oral forms are generally taken every 4 to 6 hours, with no more than 6 doses in 24 hours. The amount depends on age and the product, so check the package chart or ask me or your do...
  • It can. Drowsiness is common, so be careful driving or using machinery. Alcohol, sedatives and tranquilizers make it worse, so avoid them.
  • Oral products are not for children under 2 years, and some are not for children under 6. Children can become excitable, and overdose can be very dangerous. Always follow the age di...
📖 Read our full Diphenhydramine guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.113 $2.26 / 20 tablets
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Nov 2021 Jan 2022 Nov 2022 Nov 2025 $0.113 $0.101
▲ Up 7% over the last 6 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
46122-0425-89 You're viewing this Main listing 4 BLISTER PACK in 1 CARTON / 5 TABLET, CHEWABLE in 1 BLISTER PACK 2011-04-25 Apr 30, 2027 Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Allergy Relief Childrens 12.5 mgthis 46122-0425-89 Amerisource 5 tablets $0.113 — Availability likely —
GOOD NEIGHBOR PHARMACY Childrens Allergy Relief 12.5 mg 46122-0798-51 AMERISOURCE 10 tablets $0.113 — Availability likely —
WALGREENS Dye Free Chidrens Allergy Chews 12.5 mg 00363-1201-20 WALGREENS 10 tablets — — FDA listed —
WALGREENS Dye Free Chidrens Allergy Chews 12.5 mg 00363-2012-20 WALGREENS 10 tablets — — FDA listed —
Childrens Allergy Relief 12.5 mg 00363-4808-09 Walgreen 5 tablets — — FDA listed —
Childrens Allergy Relief 12.5 mg 00363-4810-09 Walgreen 5 tablets — — FDA listed —
up and up childrens allergy melts 12.5 mg 11673-0012-18 Target 6 tablets — — FDA listed —
Childrens Allergy Relief 12.5 mg 11822-0599-04 Rite 6 tablets — — FDA listed —
Childrens Allergy Relief 12.5 mg 36800-0585-44 Topco 6 tablets — — FDA listed —
allergy relief Childrens 12.5 mg 41163-0585-44 United 6 tablets — — FDA listed —
Childrens Chewable Allergy Relief 12.5 mg 41226-0669-02 KROGER 10 tablets — — FDA listed —
Allergy Relief Childrens 12.5 mg 41250-0599-44 Meijer 6 tablets — — Discontinued —
Childrens Allergy Relief 12.5 mg 49035-0599-09 Wal-Mart 5 tablets — — FDA listed —
Childrens Benadryl Chewables 12.5 mg 50580-0232-01 Kenvue 10 tablets — — FDA listed —
CVS PHARMACY DYE FREE Childrens Allergy Chews 12.5 mg 51316-0153-18 CVS 6 tablets — — FDA listed —
CVS PHARMACY Childrens Allergy Chews 12.5 mg 51316-0154-18 CVS 6 tablets — — FDA listed —
DISCOUNT DRUG MART Childrens Allergy Chewable 12.5 mg 53943-0033-20 DISCOUNT 10 tablets — — FDA listed —
Childrens Allergy Relief 12.5 mg 59779-0585-07 CVS 6 tablets — — FDA listed —
Childrens Allergy Relief Dye Free 12.5 mg 59779-0869-44 CVS 6 tablets — — FDA listed —
Allergy Relief 12.5 mg 67091-0425-20 WinCo 5 tablets — — FDA listed —
Allergy Relief Childrens 12.5 mg 68016-0051-18 Chain 6 tablets — — Discontinued —
Drx Choice childrens allergy chews 12.5 mg 68163-0012-48 RARITAN 12 tablets — — FDA listed —
Dimetapp Cough and Allergy 12.5 mg 69536-0370-24 Foundation 6 tablets — — FDA listed —
Allergies MY CHILD NEEDS HELP WITH 12.5 mg 73418-0747-09 Unconditional 5 tablets — — FDA listed —
TOPCARE Childrens Allergy Chews 12.5 mg 76162-0201-20 Topco 10 tablets — — FDA listed —
MEIJER Childrens Allergy Relief Chews 12.5 mg 79481-0122-00 MEIJER 10 tablets — — FDA listed —
Childrens Allergy Relief 12.5 mg 79903-0189-20 WALMART 5 tablets — — FDA listed —
Walmart Dye Free Chidrens Allergy Chews 12.5 mg 79903-0967-20 WALMART 10 tablets — — FDA listed —
Walmart Dye Free Chidrens Allergy Chews Bubblegum 12.5 mg 79903-0968-20 WALMART 10 tablets — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2011
On the market since
Apr 2011
📍
2026
Currently FDA-listed
15 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII ZK64F7XSTX
    A red synthetic colorant made by combining D&C Red No. 27 dye with aluminum salts. It's used to give tablets, capsules, or other medicines their red or pink color.
  • UNII GE75M6YV5W
    A synthetic red colorant made by combining D&C Red No. 30 dye with aluminum oxide. It's used to give tablets, capsules, or other medications their red color and appearance.
  • UNII LX22YL083G
    A simple sugar derived from corn or other sources. It acts as a filler to give the medicine bulk and volume, and as a sweetener to improve taste in oral medications.
  • UNII 7Z8S9VYZ4B
    Ethylcellulose is a plant-derived thickener and film-former made by chemically modifying cellulose. It's used as a binder to hold tablet ingredients together, a coating to control how quickly medicine is released, or a thickener in liquid formulations.
  • UNII 9XZ8H6N6OH
    A plant-based cellulose derivative used as a binder to hold tablet ingredients together, a thickener in liquids, and a coating agent to control how fast the medicine dissolves.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII 3OWL53L36A
    A natural sugar alcohol derived from seaweed or synthesized in the lab. It's used as a filler to add bulk, a sweetener in sugar-free formulas, and a disintegrant to help tablets break apart in the stomach.
  • UNII 4ELV7Z65AP
    Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
  • UNII 96K6UQ3ZD4
    Sucralose is a synthetic sweetener made from sugar. It's added to medicines to improve taste without adding calories, helping make bitter or unpleasant-tasting drugs easier to take.
  • UNII C151H8M554
    A natural sugar derived from sugar cane or sugar beets. It's used as a sweetener, filler, and binder to improve taste, add bulk, and help hold tablet or capsule ingredients together.

10 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesD&C red #27 aluminum lake, D&C red #30 aluminum lake, dextrates hydrated, ethylcellulose, flavor, hydroxypropyl cellulose, magnesium stearate, mannitol, stearic acid, sucralose, sucrose

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAmerisource Bergen
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code46122
First marketedApr 2011
Product typeHuman Otc Drug
Portfolio206 products on file

More NDCs from Amerisource Bergen labeler code 46122

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 26 words ▾

Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose itchy, watery eyes sneezing itching of the nose or throat

⏱️ Dosage and Administration 98 words ▾

Directions find right dose on chart below chew or crush tablets completely before swallowing; do not swallow tablets whole take every 4 to 6 hours, or as directed by a doctor do not take more than 6 times in 24 hours Age (yr) Dose (chewable tablets) children under 2 years do not use children 2 to 5 years do not use unless directed by a doctor children 6 to 11 years 1 to 2 chewable tablets (12.5 mg to 25 mg) adults and children 12 years and over 2 to 4 chewable tablets (25 mg to 50 mg)

⚠️ Warnings 127 words ▾

Warnings Do not use with any other product containing diphenhydramine, even one used on skin to make a child sleepy Ask a doctor before use if you have glaucoma a breathing problem such as emphysema or chronic bronchitis difficulty in urination due to enlargement of the prostate gland Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers. When using this product marked drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery avoid alcoholic beverages excitability may occur, especially in children If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 39 words ▾

Other information TAMPER EVIDENT: DO NOT USE IF OUTER PACKAGE IS OPENED OR BLISTER IS TORN OR BROKEN store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) avoid high humidity see end flap for expiration date and lot number

🧪 Active Ingredient 10 words ▾

Active ingredient (in each chewable tablet) Diphenhydramine HCl 12.5 mg

🧪 Inactive Ingredients 25 words ▾

Inactive ingredients D&C red #27 aluminum lake, D&C red #30 aluminum lake, dextrates hydrated, ethylcellulose, flavor, hydroxypropyl cellulose, magnesium stearate, mannitol, stearic acid, sucralose, sucrose

🎯 Purpose 2 words ▾

Purpose Antihistamine

📄 Do Not Use 19 words ▾

Do not use with any other product containing diphenhydramine, even one used on skin to make a child sleepy

📄 Ask a Doctor Before Use If 28 words ▾

Ask a doctor before use if you have glaucoma a breathing problem such as emphysema or chronic bronchitis difficulty in urination due to enlargement of the prostate gland

📄 Ask a Doctor or Pharmacist Before Use If 14 words ▾

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.

📄 When Using This Product 34 words ▾

When using this product marked drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery avoid alcoholic beverages excitability may occur, especially in children

🤰 If Pregnant or Breast-Feeding 10 words ▾

If pregnant or breast-feeding, ask a health professional before use.

📄 Keep Out of Reach of Children 21 words ▾

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 4 words ▾

Questions or comments? 1-800-426-9391

📄 Package Label / Principal Display Panel 135 words ▾

Principal display panel Good Neighbor Pharmacy ® Compare to Children's Benadryl ® Chewables active ingredient* NDC 46122-425-89 For Ages 6-11 CHILDREN'S Allergy Relief diphenhydramine HCl 12.5 mg / chewable tablets Antihistamine Relief of: •Sneezing • Runny Nose •Itchy Throat • Itchy, Watery Eyes Cherry Flavor Chew or crush tablets completely before swallowing. Do not swallow tablets whole. 20 Chewable Tablets ι 12.5 mg Each Actual Size Distributed By AmerisourceBergen 1 West First Avenue Conshohocken, PA19428 Questions or Concerns? www.mygnp.com *This product is not manufactured or distributed by Johnson & Johnson Corporation, owner of the registered trademark Children's Benadryl ® Chewables.

50844 REV1218B59909 GOOD NEIGHBOR PHARMACY BRAND PRODUCTS SATISFACTION GUARANTEED TAMPER EVIDENT: DO NOT USE IF PACKAGE IS OPENED OR IF BLISTER UNIT IS TORN, BROKEN OR SHOWS ANY SIGNS OF TAMPERING GNP 44-599 GNP 44-599

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Diphenhydramine HCl (matched by generic name) — the program that covers self-administered drugs. 8 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Diphenhydramine HCl. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$374.3K
Claims incl. refills
20.3K
Beneficiaries
11.2K
Spend / beneficiary
$33.36
Spend / claim
$18.44
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.
← 46122-0424-62 · Amerisource 46122-0428-62 · Amerisource →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.