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CLEAR IMPROVEMENT ACNE CLEARING HYDRATING LTN SALICYLIC ACID 15 mg/mL Lotion, 15 mL — NDC 59427-0117-02 package photo

CLEAR IMPROVEMENT ACNE CLEARING HYDRATING LTN SALICYLIC ACID 15 mg/mL Lotion, 15 mL

by ORIGINS NATURAL RESOURCES INC. · 15 mL in 1 BOTTLE (59427-117-02)
NDC 59427-0117-02
🏷️ FDA NDC (as labeled) 59427-117-02 billing pads the product segment with a zero
This package
Contains15 mL Pack sizes3 compare ↓
Also comes in: 50 mL 59427-0117-01 5 ml 59427-0117-03
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 59427-117-02
Product NDC 59427-117
11-digit billing NDC 59427011702
RxCUI 422997
UNII O414PZ4LPZ
Application # M006
SPL Set ID 10a4bae1-bbbb-0bf3-e063-6294a90a4af6
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2024-02-05
Route TOPICAL
Dosage form LOTION
Substance SALICYLIC ACID
Why two NDCs? The FDA registers this code as 59427-117-02 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 59427-0117-02. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Salicylic acid and derivatives class.

Drug family (ATC) Salicylic acid and derivatives, Other antifungals for topical use, Antiinflammatory agents, non-steroids
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerORIGINS NATURAL RESOURCES INC.
FDA applicationM006 (OTC MONOGRAPH DRUG)
Labeler code59427
First marketedFeb 2024
Product typeHuman Otc Drug
Portfolio13 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

📖 What it is MedlinePlus · NLM

Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is also used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should not be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or b...

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • It's designed to treat acne. Salicylic acid helps by loosening and removing dead skin cells that clog pores — the buildup that leads to breakouts. The multi-step system on this lab...
  • What is this salicylic acid product actually supposed to do for my skin?
  • Some mild tingling, stinging, and peeling is actually expected — that's the salicylic acid doing its job by clearing away dead skin cells. But if the burning or peeling feels exces...
  • My skin feels like it's burning and peeling. Is that normal?
📖 Read our full Salicylic Acid Topical guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 50 mL 5 ml
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
ACNE solutions CLARIFYING 15 mg/mL 49527-0723-01 CLINIQUE 1 bottle — — FDA listed —
SkinCeuticals Blemish Plus Age Defense Acne Treatment 15 mg/mL 49967-0097-05 L'Oreal 1 bottle — — FDA listed —
Kiehls Since 1851 Dermatologist Solutions Breakout Control Acne Treatment Facial 15 mg/mL 49967-0875-02 L'Oreal 5 ml — — FDA listed —
Clear Improvement Acne Clearing Hydrating Ltn 15 mg/mLthis 59427-0117-02 ORIGINS 15 ml — — FDA listed —
Byoma Acne Control Moisturizer 15 mg/mL 84821-0006-01 Byoma 50 ml — — FDA listed —
Kiehls Since 1851 Blue Herbal Acne Cleanser Treatment with Frankincense and Ginger Root 15 mg/mL 49967-0086-01 L'Oreal 75 ml — — FDA listed —
Kiehls Since 1851 Blue Herbal Acne Cleanser Treatment 15 mg/mL 49967-0618-01 L'Oreal 75 ml — — FDA listed —
SkinCeuticals Blemish Plus Age Defense Acne Treatment 15 mg/mL 82046-0558-01 LOreal 1 bottle — — FDA listed —
Proactiv Blemish Control Body Cream 15 mg/mL 11410-0214-01 Alchemee, 1 tube — — FDA listed —
Thayers Natural Remedies Since 1847 Blemish Clearing Cleanser 15 mg/mL 49967-0070-01 LOreal 132 ml — — FDA listed —
Super Spot Remover Acne Treatment 15 mg/mL 59427-0005-01 ORIGINS 10 ml — — FDA listed —
SUNDAY RILEY U.F.O Acne Treatment Face Oil 15 mg/mL 73001-0460-05 Sunday 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2024
On the market since
Feb 2024
📍
2026
Currently FDA-listed
2 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📊 Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Salicylic Acid (matched by generic name) — the program that covers self-administered drugs. 2 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Salicylic Acid. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$11.2K
Claims incl. refills
43
Beneficiaries
35
Spend / beneficiary
$319.01
Spend / claim
$259.66
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for CLEAR IMPROVEMENT ACNE CLEARING HYDRATING LTN (this brand).

Top reported reactions

Vomiting216
Pruritus205
Weight Decreased188
Condition Aggravated184
Urticaria184
Weight Increased183
Hypertension181

Age at onset

Neonate7
Infant1
Child8
Adolescent5
Adult170
Elderly94

Reporter sex

1,853 reports
Male · 37%
Female · 63%
Unknown · 0%

Serious outcomes

Hospitalization623
Death611
Disabling124
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 252 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
59427-0117-01 1 BOTTLE in 1 CARTON (59427-117-01) / 50 mL in 1 BOTTLE 2024-02-05 Active
59427-0117-02 You're viewing this 15 mL in 1 BOTTLE (59427-117-02) 2024-02-05 Active
59427-0117-03 5 mL in 1 BOTTLE (59427-117-03) 2024-02-05 Active

Pack size FAQ

What quantity is in NDC 59427-0117-02?
NDC 59427-0117-02 contains 15 mL — 15 ml in 1 bottle.
What is the difference between NDC 59427-0117-02 and NDC 59427-0117-03?
Both are CLEAR IMPROVEMENT ACNE CLEARING HYDRATING LTN SALICYLIC ACID 15 mg/mL Lotion — the drug itself is identical. NDC 59427-0117-02 is the 15 mL package, while NDC 59427-0117-03 is the 5 ml package.
What NDC number is used to bill for this package of CLEAR IMPROVEMENT ACNE CLEARING HYDRATING LTN SALICYLIC ACID 15 mg/mL Lotion?
Bill NDC 59427-0117-02 — the 11-digit billing format is 59427011702. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 59427-117-02, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 59427-0117-02, written without dashes as 59427011702. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 59427-0117-02, the first segment (59427) is the labeler code FDA assigned to ORIGINS NATURAL RESOURCES INC.; the middle segment (0117) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (02) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by ORIGINS NATURAL RESOURCES INC.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 1 bottle (59427-0117-01), 5 ml (59427-0117-03). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
ORIGINS NATURAL RESOURCES INC. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 6 words ▾

Use for the treatmenet of acne

⏱️ Dosage and Administration 61 words ▾

Directions Cleanse skin throughly before applying Cover the entire affected area with one application daily Because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor. If bothersome dryness or peeling occurs, reduce application to once a day or every other day

⚠️ Warnings 60 words ▾

Warnings For External use only When using this product skin irritattion and dryness is more likely to occur if you use another topical acne medication at the same time. If this occurs, only use one topical acne medication at a time. Keep out of reach of children If swallowed, get medical help or contact a poison control center right away.

🧪 Active Ingredient 5 words ▾

Active Ingredient Salicylic Acid 1.5%

🧪 Inactive Ingredients 74 words ▾

Inactive Ingredients water\aqua\eau,glycerin,octyldodecanol,butylene glycol,dicaprylyl carbonate,hamamelis virginiana (witch hazel) water,cetearyl olivate,sodium polyacryloyldimethyl taurate,sorbitan olivate,charcoal powder,saccharomyces/zinc ferment,zinc pca,sodium hyaluronate,algae extract,laminaria saccharina extract,lactobacillus ferment,sodium pca,dipotassium glycyrrhizate,glycine soja (soybean) seed extract,glycine soja (soybean) oil,caffeine,sucrose,tocopherol,lauroyl lysine,xanthan gum,sodium phytate,sodium citrate,sodium hydroxide,lavandula angustifolia (lavender) oil*, citrus limon (lemon) peel oil*, mentha viridis (spearmint) leaf oil*, gaultheria procumbens (wintergreen) leaf oil*, cananga odorata flower oil*, eugenia caryophyllus (clove) bud oil*, rosmarinus officinalis (rosemary) leaf oil*,linalool,citral,limonene,eugenol,geraniol,silica,phenoxyethanol,potassium sorbate,sodium benzoate,benzoic acid <iln52347> * essential oil

🎯 Purpose 3 words ▾

Purpose Acne Treatment

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 59427-0116-01 · ORIGINS 59427-0118-01 · ORIGINS →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.