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Leader Ready to Use Saline Laxative Sodium Phosphate, Dibasic and Sodium Phosphate, Monobasic, Unspecified Form 7 g/118mL; 19 g/118mL Enema — NDC 70000-0108-1 (Billing 70000-0108-01)

by Cardinal Health · 1 BOTTLE in 1 CARTON / 133 mL in 1 BOTTLE

This is a package of Leader Ready to Use Saline Laxative Sodium Phosphate, Dibasic and Sodium Phosphate, Monobasic, Unspecified Form 7 g/118mL; 19 g/118mL Enema from Cardinal Health, marketed since Feb 2013 and currently FDA-listed, this package's marketing is listed to end Feb 2027; retail pharmacies pay about $0.0081 per mL (NADAC). It is the main listing for this product, which comes in 2 package sizes.

NDC 70000-0108-01
🏷️ FDA NDC (as labeled) 70000-0108-1 billing pads the package segment with a zero
This package
Contains133 mL in 1 bottle Cost per mL$0.0081 NADAC Per package$1.08 / 133 ml Pack sizes2 compare ↓
Also priced by: Medicaid pays $0.0284/unit — full pricing hub ↓
Main listing for product 70000-0108 · Also comes in: 2 bottles 70000-0108-2
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Oct 1, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 70000-0108-1
Product NDC 70000-0108
11-digit billing NDC 70000010801
NCPDP billing unit ML — per mL (volume)
RxCUI 283100
UNII GR686LBA74, 3980JIH2SW
Application # M007
SPL Set ID 1b4f9c28-0547-4922-aa15-990c6fd9dc9f
Mechanism of action Osmotic Activity
Physiologic effect Increased Large Intestinal Motility; Inhibition Large Intestine Fluid/Electrolyte Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2013-02-19
Marketing end 2027-02-28
Route RECTAL
Dosage form ENEMA
Substance SODIUM PHOSPHATE, DIBASIC, UNSPECIFIED FORM; SODIUM PHOSPHATE, MONOBASIC, UNSPECIFIED FORM

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 46109902125100
GPI class Enema Ready-To-Use
GCN Seq No 003029
GCN 66559
HICL code 001330
Ingredient (HICL) Sodium Phosphate,Mono-Dibasic
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q3
Therapeutic class — intermediate (HIC2) Anal-Rectal Preparations
HIC3 code Q3S
Therapeutic class — specific (HIC3) Laxatives, Local/Rectal
AHFS code 56:12.00.00
AHFS class Cathartics And Laxatives
FDB label name ENEMA READY TO USE
FDB brand name Enema
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 003029
  • GCN: 66559
  • GPI-14 (Medi-Span): 46109902125100
  • HICL (First Databank): 001330
  • AHFS class code: 56:12.00.00
  • RxCUI (RxNorm): 283100
Why two NDCs? The FDA registers this code as 70000-0108-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 70000-0108-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name ENEMA READY TO USE Ingredient Sodium Phosphate,Mono-Dibasic
🧪 What is this product?

This is an over-the-counter enema product containing sodium phosphate salts, marketed under FDA's established rules for laxative products. The two forms of sodium phosphate work together as osmotic laxatives, drawing water into the bowel to soften stool and promote bowel movement. It is administered rectally and is typically used to relieve occasional constipation or to prepare the bowel before medical procedures. This is an OTC monograph drug, meaning it follows a standard FDA category rule rather than an individual product application.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.008 $1.08 / 133 ml
Medicaid paysCMS SDUD · 12 mo $0.0284 $3.78 / 133 ml
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Dec 2021 Apr 2022 Sep 2022 Feb 2024 $0.008 $0.006
▲ Up 35% over the last 15 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startMarketing endStatus
70000-0108-01 You're viewing this Main listing 1 BOTTLE in 1 CARTON / 133 mL in 1 BOTTLE $0.0081 / mL $1.07 2013-02-19 Feb 28, 2027 Active
70000-0108-02 70000-0108-2 2 BOTTLE in 1 CARTON / 133 mL in 1 BOTTLE $0.0065 / mL $1.74 2013-02-19 Feb 28, 2027 Active

Per mL, this pack runs about 25% above the cheapest pack (NDC 70000-0108-02, $0.0065 vs $0.0081 NADAC).

In Medicaid, this is the most-dispensed pack of this product — about 78% of fills over the last four reported quarters. See all packs ↓

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 1 bottle in 1 carton / 133 ml in 1 bottle.
What NDC number is used to bill for this package of Leader Ready to Use Saline Laxative Sodium Phosphate, Dibasic and Sodium Phosphate, Monobasic, Unspecified Form 7 g/118mL; 19 g/118mL Enema?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Sunmark Saline Single Laxative 7 g/118mL; 19 g/118mL 49348-0186-14 Strategic 2 bottles $0.007 — FDA listed save 19%
Saline Laxative 7 g/133mL; 19 g/133mL 00904-6320-78 Major 133 ml $0.007 — Availability likely save 17%
Foster and Thrive Ready to Use Saline Laxative 7 g/118mL; 19 g/118mL 70677-1089-01 McKesson 1 bottle $0.007 — Availability likely save 17%
Quality Choice Laxative 7 g/118mL; 19 g/118mL 83324-0292-45 Chain 1 bottle $0.007 — Availability likely save 17%
Quality Choice Laxative 7 g/118mL; 19 g/118mL 83324-0293-90 Chain 2 bottles $0.007 — Availability likely save 17%
HealthMart Saline Single Laxative 7 g/118mL; 19 g/118mL 62011-0271-01 Strategic 1 bottle $0.008 — FDA listed —
Leader Ready to Use Saline Laxative 7 g/118mL; 19 g/118mLthis 70000-0108-01 Cardinal 1 bottle $0.008 — FDA listed —
Fleet 7 g/118mL; 19 g/118mL 00132-0201-40 C.B. 133 ml $0.010 — Availability likely +18%
Pedia-Lax 3.5 g/66mL; 9.5 g/66mL 00132-0202-20 C.B. 66 ml $0.020 — Availability likely +153%
Saline Laxative 7 g/118mL; 19 g/118mL 00363-0005-37 Walgreen 1 bottle — — FDA listed —
Equate Ready-to-Use Enema Laxative 7 g/118mL; 19 g/118mL 49035-0002-24 WalMart 6 bottles — — FDA listed —
Pure and Gentle Laxative 7 g/118mL; 19 g/118mL 53329-0014-11 Medline 1 bottle — — FDA listed —
Freds Saline Twin Pack Laxative 7 g/133mL; 19 g/133mL 55315-0301-01 FRED'S 2 bottles — — FDA listed —
Rexall Ready to use 4pk LAXATIVE 7 g/118mL; 19 g/118mL 55910-0999-06 Dolgencorp, 4 bottles — — FDA listed —
CVS Pharmacy 7 g/118mL; 19 g/118mL 59779-0959-11 CVS 1 bottle — — FDA listed —
NATUREPLEX Enema 19 g/133mL; 7 g/133mL 67234-0020-01 Natureplex, 1 bottle — — FDA listed —
Saline Enema 7 g/118mL; 19 g/118mL 67777-0402-02 Dynarex 1 bottle — — FDA listed —
Reflief Saline Laxative Pediatric Ready To Use 3.5 g/59mL; 9.5 g/59mL 69626-0085-07 Leosons 1 bottle — — FDA listed —
Quality Choice Single Saline Laxative 7 g/118mL; 19 g/118mL 71443-0001-06 Alcyon 6 bottles — — FDA listed —
Pro-Enema Single Saline Laxative 7 g/118mL; 19 g/118mL 71451-0001-01 Propharma 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2013
On the market since
Feb 2013
📍
2026
Currently FDA-listed
13 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerCardinal Health
FDA applicationM007 (OTC MONOGRAPH DRUG)
Labeler code70000
First marketedFeb 2013
Product typeHuman Otc Drug
Portfolio84 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 15 words ▾

Use relieves occasional constipation this product generally produces bowel movement in 1 to 5 minutes

⏱️ Dosage and Administration 67 words ▾

Directions (or as directed by a doctor) Single daily dosage (per 24 hours) Do not use if taking another sodium phosphate product. Do not use more unless directed by a doctor. See Warnings . Adults and children 12 years of age and older 1 bottle once daily Children 2 to under 12 years of age Use Pediatric Enema Children under 2 years of age DO NOT USE

⚠️ Warnings 219 words ▾

Warnings Dosage warning Using more than one enema in 24 hours can be harmful. For rectal use only. Do not use on children under 2 years of age Ask a doctor before use if you have already used a laxative for more than 3 days have kidney disease, have heart problems, or are dehydrated are 55 years of age or older are on a sodium-restricted diet have abdominal pain, nausea, or vomiting have a sudden change in bowel habits lasting more than 2 weeks Ask a doctor or pharmacist before use if you are taking any other drug.

Take this product two or more hours before or after other drugs. Laxatives may affect how other drugs work. When using this product do not use more than directed.

Serious side effects may occur from excess dosage do not use for more than 3 days, without asking a doctor Stop use and ask a doctor if you have rectal bleeding you have no bowel movement within 30 minutes of enema use you have symptoms of dehydration (thirstiness, dizziness, vomiting, urinating less often than normal) These symptoms may indicate a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away: 800-222-1222.

📦 Storage and Handling 43 words ▾

Other information each 118 ml contains sodium 4.3 g store at 15 to 30°C (59 to 86°F) additional liquids by mouth are recommended while using this product Tamper Evident: DO NOT USE IF TOP OR BOTTOM FLAP OF CARTON IS TORN OR MISSING.

🧪 Active Ingredient 22 words ▾

Active ingredients (in each 118mL delivered dose) Purpose Dibasic Sodium Phosphate 7 g Saline laxative Monobasic Sodium Phosphate 19 g Saline laxative

🧪 Inactive Ingredients 8 words ▾

Inactive ingredients benzalkonium chloride, disodium EDTA, purified water

🎯 Purpose 22 words ▾

Active ingredients (in each 118mL delivered dose) Purpose Dibasic Sodium Phosphate 7 g Saline laxative Monobasic Sodium Phosphate 19 g Saline laxative

📄 Do Not Use 10 words ▾

Do not use on children under 2 years of age

📄 Ask a Doctor Before Use If 56 words ▾

Ask a doctor before use if you have already used a laxative for more than 3 days have kidney disease, have heart problems, or are dehydrated are 55 years of age or older are on a sodium-restricted diet have abdominal pain, nausea, or vomiting have a sudden change in bowel habits lasting more than 2 weeks

📄 Ask a Doctor or Pharmacist Before Use If 33 words ▾

Ask a doctor or pharmacist before use if you are taking any other drug. Take this product two or more hours before or after other drugs. Laxatives may affect how other drugs work.

📄 When Using This Product 30 words ▾

When using this product do not use more than directed. Serious side effects may occur from excess dosage do not use for more than 3 days, without asking a doctor

📄 Stop Use and Ask a Doctor If 42 words ▾

Stop use and ask a doctor if you have rectal bleeding you have no bowel movement within 30 minutes of enema use you have symptoms of dehydration (thirstiness, dizziness, vomiting, urinating less often than normal) These symptoms may indicate a serious condition.

🤰 If Pregnant or Breast-Feeding 10 words ▾

If pregnant or breast-feeding, ask a health professional before use.

📄 Keep Out of Reach of Children 20 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away: 800-222-1222.

📄 Questions or Comments 4 words ▾

Questions or comments? 866-323-0107

📄 Package Label / Principal Display Panel 65 words ▾

PRINCIPAL DISPLAY PANEL - 133 mL Bottle Carton LEADER ™ NDC 70000-0108-1 Ready-To-Use Saline Enema Dibasic Sodium Phosphate, 7 g Monobasic Sodium Phosphate, 19 g Saline Laxative For Relief of Occasional Constipation Not Made with Natural Rubber Latex COMPARE TO FLEET ® SALINE ENEMA active ingredients* 1 BOTTLE 100% Money Back Guarantee

4.5 FL OZ (133 mL) PRINCIPAL DISPLAY PANEL - 133 mL Bottle Carton

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q4 2025 · 4 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
266
Units reimbursed last 4 qtrs
126.8K
Gross reimbursed last 4 qtrs
$3.6K
Avg / prescription
$13.53
Avg / unit
$0.0284
Latest quarter Q4 2025
0Rx
Medicaid pays / mL
$0.0284
gross reimbursed
vs
NADAC / mL
$0.0081
acquisition cost
=
Spread
+$0.0203
+251% vs cost
What Medicaid paid per mL (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
86% FFS 14% MCO
Fee-for-service · 230 Rx Managed care · 36 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: no data reported WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: no data reported MN Wisconsin: no data reported WI Michigan: 6,974 units · 69.5 per 100k residents MI New York: 98,824 units · 505 per 100k residents NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: no data reported NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: no data reported IN Ohio: no data reported OH Pennsylvania: 1,862 units · 14.4 per 100k residents PA New Jersey: no data reported NJ Massachusetts: no data reported MA California: 19,101 units · 49.0 per 100k residents CA Utah: no data reported UT Colorado: no data reported CO Nebraska: no data reported NE Missouri: no data reported MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: no data reported VA Maryland: no data reported MD Connecticut: no data reported CT Rhode Island: no data reported RI Arizona: no data reported AZ New Mexico: no data reported NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: no data reported DC Hawaii: no data reported HI Texas: no data reported TX Florida: no data reported FL
Units reimbursed · per 100k residents
14.4505
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 New York 505 /100k
2 Michigan 69.5 /100k
3 California 49.0 /100k
4 Pennsylvania 14.4 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
1 bottle this page70000-0108-01 266 Rx · $3,599
2 bottles70000-0108-02 73 Rx · $876
Drug total (last 4 qtrs): 339 Rx · 149,491 units · $4,475 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.
← 70000-0099-01 · CARDINAL 70000-0109-01 · Cardinal →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.