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THE SKIN HOUSE Wrinkle SystemCream adenosine .04 g/100g Cream, 50 g — NDC 73590-0033-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

THE SKIN HOUSE Wrinkle SystemCream adenosine .04 g/100g Cream, 50 g — NDC 73590-0033-1 (Billing 73590-0033-01)

by NOKSIBCHO cosmetic Co., Ltd. · 50 g in 1 BOTTLE

This is a package of 50 g of THE SKIN HOUSE Wrinkle SystemCream adenosine .04 g/100g Cream from NOKSIBCHO cosmetic Co., Ltd., marketed since Mar 2020 and currently FDA-listed. It is this product's only package size.

NDC 73590-0033-01
🏷️ FDA NDC (as labeled) 73590-0033-1 billing pads the package segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 73590-0033-1 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
73590 labeler · 0033 product · 1 package
Package marketed since
Mar 8, 2020
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC)
8809080821190
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 73590-0033-1
Product NDC 73590-0033
11-digit billing NDC 73590003301
UNII K72T3FS567
UPC 8809080821190
SPL Set ID a21fa53d-f7ae-071c-e053-2995a90adbb7
Established class (EPC) Adenosine Receptor Agonist
Mechanism of action Adenosine Receptor Agonists
DEA schedule Non-controlled
Marketing category UNAPPROVED DRUG OTHER
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2020-03-08
Route TOPICAL
Dosage form CREAM
Substance ADENOSINE
Why two NDCs? The FDA registers this code as 73590-0033-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 73590-0033-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

🧪 What is this product?

The Skin House Wrinkle SystemCream is a topical cream containing adenosine as its active ingredient. Adenosine is commonly included in skin care products for its role as an adenosine receptor agonist, which is typically used in cosmetic formulations aimed at skin appearance. This product is marketed as an unapproved drug and has not received FDA approval.

Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
73590-0033-01 You're viewing this Main listing 50 g in 1 BOTTLE 2020-03-08 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
by Selected Recovering Almighty .04 g/100g 73509-0090-01 Garam 300 g — — Discontinued —
THE SKIN HOUSE Wrinkle SystemCream .04 g/100gthis 73590-0033-01 NOKSIBCHO 50 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2020
On the market since
Mar 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

1 inactive ingredient listed in the exact product block matched to this NDC.

The official label also statesWater Butylene glycol Glycerin Squalane Cyclomethicone Mineral Oil Dimethicone 1,2-Hexanediol Sodium Hyaluronate Cetyl Ethylhexanoate Macadamia Integrifolia Seed Oil Caprylic/Capric Triglyceride Cetearyl Alcohol Stearic Acid Dimethicone/Vinyl Dimethicone Crosspolymer PEG-100 Stearate Betaine Methyl Gluceth-20 PEG-10 Dimethicone Polysorbate 60 Sorbitan Isostearate Beeswax Glyceryl Stearate Carbomer Sorbitan Stearate Sodium Polyacrylate C13-14 Isoparaffin Laureth-7 Hydrolyzed Collagen Hydrogenated Lecithin Linoleic acid Water Ceramide NP TEA-cocoyl Glutamate Camellia Japonica seed oil Aloe Barbadensis Leaf Extract Arginine Myrciaria Dubia Fruit Extract Euterpe Oleracea Fruit Extract Panthenol Allantoin Disodium EDTA Panax ginseng callus culture extract Bambusa vulgaris Callus Culture extract Aloe vera Callus Culture extract Leontopodium alpinum extract Thymus Vulgaris (Thyme) Extract Buddleja Davidii Extract Snail Secretion Filtrate Phenoxyethanol Ethylhexylglycerin CI 19140 CI 15985 Parfume

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerNOKSIBCHO cosmetic Co., Ltd.
Labeler code73590
First marketedMar 2020
Product typeHuman Otc Drug
Portfolio44 products on file

More NDCs from NOKSIBCHO cosmetic Co., Ltd. labeler code 73590

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 6 words ▾

apply proper amount to the skin

⚠️ Warnings 60 words ▾

For external use only When using this product ■ if the following symptoms occurs after use, stop use and consult with a skin specialist red specks, swelling, itching ■ don’t use on the part where there is injury, eczema, or dermatitis Keep out of reach of children ■ if swallowed, get medical help or contact a person control center immediately

🧪 Active Ingredient 1 words ▾

adenosine

🧪 Inactive Ingredients 116 words ▾

Water Butylene glycol Glycerin Squalane Cyclomethicone Mineral Oil Dimethicone 1,2-Hexanediol Sodium Hyaluronate Cetyl Ethylhexanoate Macadamia Integrifolia Seed Oil Caprylic/Capric Triglyceride Cetearyl Alcohol Stearic Acid Dimethicone/Vinyl Dimethicone Crosspolymer PEG-100 Stearate Betaine Methyl Gluceth-20 PEG-10 Dimethicone Polysorbate 60 Sorbitan Isostearate Beeswax Glyceryl Stearate Carbomer Sorbitan Stearate Sodium Polyacrylate C13-14 Isoparaffin Laureth-7 Hydrolyzed Collagen Hydrogenated Lecithin Linoleic acid Water Ceramide NP TEA-cocoyl Glutamate Camellia Japonica seed oil Aloe Barbadensis Leaf Extract Arginine Myrciaria Dubia Fruit Extract Euterpe Oleracea Fruit Extract Panthenol Allantoin Disodium EDTA Panax ginseng callus culture extract Bambusa vulgaris Callus Culture extract Aloe vera Callus Culture extract Leontopodium alpinum extract Thymus Vulgaris (Thyme) Extract Buddleja Davidii Extract Snail Secretion Filtrate Phenoxyethanol Ethylhexylglycerin CI 19140 CI 15985 Parfume

🎯 Purpose 2 words ▾

wrinkle care

📄 Keep Out of Reach of Children 7 words ▾

keep out of reach of the children

📄 Package Label / Principal Display Panel 1 words ▾

label

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product Marketed without an FDA application

Listed without an FDA application

This product's marketing category indicates it is marketed without an approved FDA application (no NDA, ANDA, or BLA on file). Having an NDC does not by itself establish FDA approval — the NDC Directory is a listing system, not an approval decision. Approval-linked data such as Orange Book therapeutic-equivalence ratings therefore does not apply.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Drug Other". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by NOKSIBCHO cosmetic Co., Ltd.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
NOKSIBCHO cosmetic Co., Ltd. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 73590-0032-01 · NOKSIBCHO 73590-0034-01 · NOKSIBCHO →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.