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Stomach Relief - Maximum Strength BISMUTH SUBSALICYLATE 1050 mg/30mL Liquid, 237 mL — NDC 76281-538-26 (Billing 76281-0538-26)

by AptaPharma Inc. · 237 mL in 1 BOTTLE

This is a package of 237 mL of Stomach Relief - Maximum Strength BISMUTH SUBSALICYLATE 1050 mg/30mL Liquid from AptaPharma Inc., marketed since Oct 2018 and currently FDA-listed. It is this product's only package size.

NDC 76281-0538-26
🏷️ FDA NDC (as labeled) 76281-538-26 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 76281-538-26
Product NDC 76281-538
11-digit billing NDC 76281053826
RxCUI 308763
UNII 62TEY51RR1
UPC 0376281538267
Application # M008
SPL Set ID 15cd9163-16d6-4332-9e26-77c05e0a26a7
Established class (EPC) Bismuth
Chemical class Bismuth
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2018-10-01
Route ORAL
Dosage form LIQUID
Substance BISMUTH SUBSALICYLATE
Quick answers
  • RxCUI (RxNorm): 308763
Why two NDCs? The FDA registers this code as 76281-538-26 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 76281-0538-26. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Bismuth class.

Pharmacologic class Bismuth
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📗 Our plain-language guide HelloPharmacist
  • It relieves diarrhea, including traveler's diarrhea. It also helps with upset stomach after overindulging in food and drink, such as heartburn, indigestion, nausea, gas, belching a...
  • Use it only until the diarrhea stops, and no more than 2 days. If you're not better by then, or you get worse sooner, stop and see a doctor. Drink plenty of clear fluids while you...
  • That's a known, temporary and harmless effect of this medicine. But black stool can also signal bleeding, so do not use it if you already have bloody or black stool.
  • Children under 12 should be checked by a doctor first. Children and teens who have or are recovering from chicken pox or flu-like symptoms should not use it because of Reye's syndr...
📖 Read our full Bismuth Subsalicylate guide →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
76281-0538-26 You're viewing this Main listing 237 mL in 1 BOTTLE 2018-10-01 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Stomach Relief Ultra 525 mg/15mL 70000-0045-01 Cardinal 355 ml $0.010 — Availability likely —
Ultra Stomach Relief 525 mg/15mL 62011-0436-01 Strategic 237 ml $0.010 — Discontinued —
Stomach Relief Ultra 525 mg/15mL 00536-1287-36 Rugby 237 ml $0.011 — Availability likely —
Good Neighbor Ultra Strength Stomach Relief 525 mg/15mL 46122-0747-06 AMERISOURCE 236 ml $0.012 — Availability likely —
Quality Choice Stomach Relief 528 525 mg/15mL 83324-0021-08 Chain 236 ml $0.012 — Availability likely —
Walgreen Ultra Strength Pink Bismuth 525 mg/15mL 00363-7070-04 WALGREENS 118 ml — — FDA listed —
Walgreen Stomach Relief Ultra Strength 525 mg/15mL 00363-7071-12 WALGREENS 354 ml — — FDA listed —
Soothe Ultra Strength 525 mg/15mL 00363-7370-04 Walgreens 118 ml — — FDA listed —
Ultra Strenght Pink Bismuth 525 mg/15mL 11673-0907-08 TARGET 236 ml — — FDA listed —
RITE AID Ultra Strnght Pink Bismuth 525 mg/15mL 11822-7070-02 RITE 354 ml — — FDA listed —
SIGNATURE CARE Ultra Strength Stomach 525 mg/15mL 21130-0193-12 SAFEWAY 354 ml — — FDA listed —
Ultra Stomach Relief 525 mg/15mL 21130-0662-08 Safeway, 237 ml — — FDA listed —
TopCare Stomach Relief Ultra Strength 525 mg/15mL 36800-0341-08 TOPCO 236 ml — — FDA listed —
Pepto-Bismol Ultra 525 mg/15mL 37000-0440-04 The 118 ml — — FDA listed —
Pepto-Bismol Ultra Cherry 525 mg/15mL 37000-0441-04 The 118 ml — — FDA listed —
HEB Stomach Relief Max Strength 1050 mg/30mL 37808-0770-08 HEB 236 ml — — FDA listed —
Equaline Maximum Strength Stomach Relief 1050 mg/30mL 41163-0937-04 UNITED 237 ml — — FDA listed —
Meijer Stomach Relief Regular Strength 525 mg/15mL 41250-0211-12 MEIJER 354 ml — — FDA listed —
PUBLIX Stomach Relief Ultra Strength 525 mg/15mL 41415-0707-12 PUBLIX 354 ml — — FDA listed —
Stomach Relief Ultra 525 mg/15mL 49035-0293-12 EQUATE 355 ml — — FDA listed —
Stomach Relief Ultra Strength 525 mg/15mL 49580-0842-08 P 237 ml — — FDA listed —
Goodsense maximum strength Stomach Relief 528 1050 mg/30mL 50804-0154-04 Good 236 ml — — FDA listed —
CVS Stomach Relief Ultra Strength 525 mg/15mL 51316-0707-12 CVS 354 ml — — FDA listed —
Maximum Strength Stomach Relief 1050 mg/30mL 53041-0528-04 Guardian 236 ml — — FDA listed —
Ultra Strength Stomach Relief 525 mg/15mL 53041-0529-04 Guardian 236 ml — — FDA listed —
Stomach Relief Maximum Strength 1050 mg/30mL 53942-0558-26 Demoulas 237 ml — — FDA listed —
Maximum Strength Pink Bismuth 1050 mg/30mL 53943-0528-05 Discount 354 ml — — FDA listed —
Stomach Relief Ultra 525 mg/15mL 55319-0948-08 Family 237 ml — — FDA listed —
Kaopectate Max Peppermint Flavor Anti Diarrheal 525 mg/15mL 55505-0200-36 Kramer 236 ml — — FDA listed —
Kaopectate 525 mg/15mL 55505-0229-64 KRAMER 325 ml — — FDA listed —
Ultra Bismuth 525 mg/15mL 55910-0637-04 Dolgencorp, 118 ml — — FDA listed —
Stomach Relief Ultra 525 mg/15mL 55910-0837-08 Dolgencorp, 237 ml — — FDA listed —
QC Stomach Relief Regular Strength 525 mg/15mL 63868-0304-08 QUALITY 236 ml — — FDA listed —
Stomach Relief Ultra Strength 525 mg/15mL 63868-0813-08 QUALITY 237 ml — — Discontinued —
Stomach Relief Ultra 525 mg/15mL 63941-0737-04 Best 118 ml — — FDA listed —
WinCo FOODS Ultra Strength Stomach Relief 525 mg/15mL 67091-0363-24 WINCO 236 ml — — FDA listed —
DRx Choice Stomach Relief Regular Strength 525 mg/15mL 68163-0707-12 RARITAN 354 ml — — FDA listed —
Stomach Relief, Ultra Strength 1050 mg/30mL 68998-0558-28 Marc 354 ml — — FDA listed —
Max Strength Stomach Relief 1050 mg/30mL 69256-0528-04 Harris 236 ml — — FDA listed —
Pepto Bismol Ultra 525 mg/15mL 69423-0966-12 The 354 ml — — FDA listed —
Stomach Relief Maximum Strength 525 mg/15mL 69842-0229-12 CVS 355 ml — — FDA listed —
Ultra Strength Stomach Relief 525 mg/15mL 72476-0528-04 Retail 236 ml — — FDA listed —
Stomach Relief Ultra Strength 525 mg/15mL 72476-0737-08 Care 237 ml — — FDA listed —
Topcare Ultra Strength Stomach Relief 525 mg/15mL 76162-0022-04 Topco 236 ml — — FDA listed —
Stomach Relief - Maximum Strength 1050 mg/30mLthis 76281-0538-26 AptaPharma 237 ml — — FDA listed —
Stomach Relief, Maximum Strength 1050 mg/30mL 76281-0558-25 AptaPharma 177 ml — — FDA listed —
Quality Choice Ultra Strength Stomach Relief 525 mg/15mL 83324-0337-08 QUALITY 236 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2018
On the market since
Oct 2018
📍
2026
Currently FDA-listed
8 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAptaPharma Inc.
FDA applicationM008 (OTC MONOGRAPH DRUG)
Labeler code76281
First marketedOct 2018
Product typeHuman Otc Drug
Portfolio29 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Other Information 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 29 words ▾

Uses relieves ■ travelers' diarrhea ■ diarrhea ■ upset stomach due to overindulgence of food and drink including: ■ heart burn ■ indigestion ■ nausea ■ gas ■ belching

⏱️ Dosage and Administration 79 words ▾

Directions ■ Shake well before use ■ use dose cup or tablespoon (TBSP) ■ adults and children 12 years and over: 1 dose (30 mL or 2 TBSP) every 1 hour as needed ■ do not exceed 4 doses (120 mL or 8 TBSP) in 24 hours ■ use until diarrhea stops but not more than 2 days ■ children under 12 years: ask a doctor ■ drink plenty of clear fluids to help prevent dehydration caused by diarrhea

⚠️ Warnings 55 words ▾

Warnings Reye's syndrome : Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye's syndrome, a rare but serious illness.

🧪 Active Ingredient 15 words ▾

Active ingredient (in each 30 mL dose cup or 2 tablespoons) Bismuth subsalicylate 1050 mg

🧪 Inactive Ingredients 22 words ▾

Inactive ingredients benzoic acid, D&C red #22, D&C red # 28, flavor, purified water, saccharin sodium, salicylic acid, sodium salicylate, xantham gum

🎯 Purpose 9 words ▾

Purposes Bismuth subsalicylate .............. Upset stomach reliever and antidiarrheal

📄 Do Not Use 18 words ▾

Do not use if you have ■ an ulcer ■ a bleeding problem ■ black or bloody stool

📄 Ask a Doctor Before Use If 14 words ▾

Ask a doctor before use if you have ■ fever ■ mucus in stool

📄 Ask a Doctor or Pharmacist Before Use If 26 words ▾

Ask a doctor or pharmacist before use if you are taking any drug for ■ anticoagulation (thinning of the blood) ■ diabetes ■ gout ■ arthritis

📄 When Using This Product 16 words ▾

When using this product a temporary, but harmless, darkening of the stool and/or tongue may occur

📄 Stop Use and Ask a Doctor If 34 words ▾

Slop use and ask a doctor if ■ diarrhea lasts more than 2 days ■ symptoms get worse or last more than 2 days ■ ringing in the ears or loss of hearing occurs

🤰 If Pregnant or Breast-Feeding 11 words ▾

If pregnant or breast feeding , ask health professional before use.

📄 Keep Out of Reach of Children 22 words ▾

Keep out of reach of children . In case of overdose, get medical help or contact a Poison Control Center right away.

📄 Other Information 30 words ▾

Other information ■ each 30 ml dose cup contains: sodium 13 mg, salicylate 455 mg ■ protect from freezing ■ avoid excessive heat (over 104°F or 40°C) ■ low sodium

📄 Questions or Comments 2 words ▾

Questions? 1-877-798-5944

📄 Package Label / Principal Display Panel 109 words ▾

Principal Display Panel AP SAFE NDC 76281-538-26 *COMPARE TO the active ingredient in PEPTO-BISMOL™ MAXIMUM STRENGTH Stomach Relief Bismuth Subsalicylate Antidiarrheal / Upset Stomach Reliever Maximum Strength 5 Symptom Relief of: ● Nausea ● Heartburn ●Indigestion ● Upset stomach ● Diarrhea 8 FL OZ (237 mL) TAMPER EVIDENT: Do not use if imprinted shrinkband is missing or broken *This product is not manufactured or distributed by Procter & Gamble, Inc., the distributor of Pepto-Bismol ™ . Manufactured by: AptaPharma Inc., Made in USA 1533 Union Ave.

AP-LR-12 REV01 Pennsauken, NJ 08110 3 76281 53826 7 PEEL HERE Stomach Relief - Maximun Strength by AptaPharma Inc. res 76281-538-26 Max 8OZ

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Stomach Relief - Maximum Strength (this brand).

Top reported reactions

Nausea93
Vomiting76
Diarrhoea70
Abdominal Pain60
Pain54
Constipation48
Abdominal Distension43

Age at onset

Adolescent2
Adult39
Elderly48

Reporter sex

605 reports
Male · 44%
Female · 56%

Serious outcomes

Hospitalization265
Death125
Life-threatening51
Disabling39
Reports over time (by year) — tap or hover for the count & year
2020 2022 2024 2026 54 23
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by AptaPharma Inc.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
AptaPharma Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 76281-0537-25 · AptaPharma 76281-0557-28 · AptaPharma →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.