J9245
J9245 – Injection, melphalan hydrochloride, not otherwise specified, 50 mg · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 18 NDCs crosswalked per 50 MG $104.898/unit ASP+6%
📋 J9245 summary
J9245 is a HCPCS Level II J-code used to bill melphalan hydrochloride, not otherwise specified, 50 mg, billed per 50 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J9245: Alkeran*, Melphalan Hydrochloride, Melphalan
Code J9245
Billing unit 50 MG Payment limit $104.898/unit NDC-Crosswalk 18
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ9245
DescriptorInjection, melphalan hydrochloride, not otherwise specified, 50 mg
Billing unit50 MG
Payment limit / unit$104.898
Est. ASP / unit$98.960 est.
Mapped NDCs18
Data periodQ3 2026
Last updated2026-08-20
💊 About Melphalan DRUG GUIDE
Melphalan is used to treat multiple myeloma, a cancer of plasma cells in the bone marrow.
Different products are approved for different roles in that treatment.Evomela (intravenous injection) is used as a high-dose conditioning treatment — meaning it prepares the body before a stem cell transplant.
Ivra (intravenous injection) is used for palliative treatment of multiple myeloma in patients for whom oral therapy is not appropriate.
Oral melphalan (Alkeran tablet) is also used for palliative treatment of multiple myeloma.
Clinical overview from our editorial drug guide for Melphalan. For billing reference, see the sections above.
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$104.898
Est. ASP / unit
$98.960 est.
Est. after 2% sequester
$102.800
HCPCS dosage
50 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, melphalan hydrochloride, not otherwise specified, 50 mg
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1D
ASC payment groupYY
Action codeN — No maintenance this year
Effective date2020-07-01
Date added1995-01-01
Source: CMS HCPCS Level II code file (imported via admin).
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J9245 = 50 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J9245 WITH EST. MEDICARE PAY
18 NDCs map to J9245. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($104.898/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 23155-0355-41 | Melphalan hydrochloride KIT | Heritage | 1 KIT in 1 CARTON (23155-355-41) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 25021-0258-61 | Melphalan Hydrochloride KIT | Sagent | 1 KIT in 1 CARTON (25021-258-61) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 43598-0392-48 | Melphalan Hydrochloride KIT | Dr.Reddy's | 1 KIT in 1 CARTON (43598-392-48) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 45963-0686-02 | Melphalan | Actavis | — | — | 1 | $104.90 | — | — | CMS + PDAC |
| 63323-0760-20 | Melphalan KIT | Fresenius | 1 KIT in 1 CARTON (63323-760-20) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 67457-0195-01 | Melphalan Hydrochloride KIT | Mylan | 1 KIT in 1 CARTON (67457-195-01) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS ASP |
| 67457-0215-01 | Melphalan | Mylan | — | — | 1 | $104.90 | — | — | CMS ASP |
| 70700-0278-97 | Melphalan | Xiromed, | — | — | 1 | $104.90 | — | — | CMS ASP |
| 70860-0214-61 | Melphalan | Athenex | — | — | 1 | $104.90 | — | — | CMS + PDAC |
| 71288-0132-90 | Melphalan hydrochloride KIT | Meitheal | 1 KIT in 1 CARTON (71288-132-90) * 15 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 72266-0128-01 | Melphalan hydrochloride KIT | Fosun | 1 KIT in 1 CARTON (72266-128-01) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS ASP |
| 75907-0112-11 | Melphalan Hydrochloride KIT | Dr.Reddy's | 1 KIT in 1 CARTON (75907-112-11) * 10 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 83634-0202-61 | Melphalan Hydrochloride KIT | Avenacy | 1 KIT in 1 CARTON (83634-202-61) * 15 mL... | — | 1 | $104.90 | — | ● Active | CMS + PDAC |
| 54288-0109-02 | Melphalan hydrochloride KIT | BPI | 1 KIT in 1 CARTON (54288-109-02) * 10 mL... | — | 1 | $104.90 | — | ● Active | PDAC |
| 45963-0687-49 | MELPHALAN HYDROCHLORIDE (INNER VIAL NDC,PF) 50 MG | Unknown | — | — | 1 | $104.90 | — | — | PDAC |
| 71288-0112-90 | MELPHALAN HYDROCHLORIDE (W/10ML DILUENT,PF) 50 MG | Unknown | — | — | 1 | $104.90 | — | — | PDAC |
| 25021-0221-60 | MELPHALAN HYDROCHLORIDE (W/10ML DILUENT,PF) 50 MG | Unknown | — | — | 1 | $104.90 | — | — | PDAC |
| 42023-0149-01 | MELPHALAN HYDROCHLORIDE (W/ 10ML DILUENT) 50 MG | Unknown | — | — | 1 | $104.90 | — | — | PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$35.1K
Claims
70
Beneficiaries
65
Spend / beneficiary
$540.44
Spend / claim
$501.84
Trend by period
Where J9245 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #624 of 824
#619
ZINPLAVA J0565
$36.7K
#620
ESANO ACA, PER SQ CM... Q4275
$36.1K
#621
DERMACYTE AMN MEM AL... Q4248
$35.9K
#622
ONDANSETRON HCL(J240... J2405
$35.4K
#623
ZIEXTENZO Q5120
$35.2K
#624
ALKERAN* J9245
$35.1K
#625
GANCICLOVIR SODIUM J1570
$34.8K
#626
BYOOVIZ Q5124
$34.5K
#627
DEPO-ESTRADIOL J1000
$33.6K
#628
SURGRAFT FT PER SQ C... Q4268
$33.2K
#629
TOPOTECAN HCL J9351
$32.4K
Total claims — #664 of 824
#659
BIZENGRI J9382
73
#660
PRIMATRIX** Q4110
73
#661
HEMOFIL M* J7190
72
#662
EPIEFFECT, PER SQ CM... Q4278
72
#663
CONRAY Q9961
71
#664
ALKERAN* J9245
70
#665
NAFCILLIN SODIUM J2290
69
#666
ENGERIX-B PEDIATRIC-... 90744
68
#667
LUMIZYME J0221
68
#668
BUSULFAN* J0594
68
#669
ARANESP(J0882) J0882
68
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $35.1K | 65 | 70 | $540.44 | $501.84 |
| 2025 (Q1-Q4) | $221.7K | 280 | 343 | $791.90 | $646.45 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$31.1K
Medicare paid
$26.7K
Submitted services
253
Submitted charges
$1.32M
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
🗺️ Where J9245 is utilized
⏳
The geographic utilization map is building for this code — it aggregates millions of CMS Part B claim lines, then caches the result. Refresh in a moment; if it doesn’t appear, this code may have no reportable Part B utilization.
📊 What bills under J9245
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
18 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J9245 billing FAQ
What is HCPCS code J9245?
J9245 is a HCPCS Level II J-code used to bill Injection, melphalan hydrochloride, not otherwise specified, 50 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J9245?
One unit of J9245 represents 50 MG. Report the number of units equal to the dose administered divided by 50 MG.
How many units of J9245 should I bill?
Divide the dose administered by the code's unit size (50 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J9245?
The Medicare Part B payment limit is $104.898 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $102.800 per unit. Payment limits are revised quarterly.
Which NDCs bill under J9245?
18 NDCs currently map to J9245 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J9245 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.