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Acetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG / phenylephrine hydrochloride... — RxCUI 1233575

RxNorm drug concept · Semantic clinical drug
RxCUI 1233575 Semantic clinical drug · SCD ● Current RxNorm concept 15 FDA products 16 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1233575
Official nameAcetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG / phenylephrine hydrochloride 5 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 325 MG / diphenhydramine HCl 12.5 MG / phenylephrine HCl 5 MG Oral Tablet; APAP 325 MG / Diphenhydramine Hydrochloride 12.5 MG / Phenylephrine Hydrochloride 5 MG Oral Tablet
FDA products mapped15
Package NDCs mapped16
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 325 MG / diphenhydramine hydrochlo... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / diphenhydramine hydrochloride 12.5 MG / phenylephrine hydrochloride 5 MG Oral Tablet RxCUI 1233575

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 6

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Phenylephrine 8163
    • Acetaminophen / diphenhydramine / phenylephrine 689785
    • Diphenhydramine hydrochloride 1362
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine / phenylephrine Oral Tablet 602581
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Tablet 2647775
    • Acetaminophen / diphenhydramine / phenylephrine Oral Product 1151196
    • Acetaminophen / diphenhydramine / phenylephrine Pill 1151197
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product 2659765
    • Acetaminophen / diphenhydramine hydrochloride / phenylephrine hydrochloride Pill 2661678
    • Oral Tablet 317541
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 3

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Diphenhydramine hydrochloride 12.5 MG 882503
    • Phenylephrine hydrochloride 5 MG 1020198
  4. Packs 3

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 20 of 21 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

15 products · 16 package NDCs
16 package NDCs map to RxCUI 1233575 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00067-8137-10 1 BLISTER PACK in 1 CARTON (0067-8137-10) / 10 TABLET, FILM... Theraflu ExpressMax Nighttime Severe Cold and Cough Haleon US Holdings LLC 2017-06-08
00067-8137-20 2 BLISTER PACK in 1 CARTON (0067-8137-20) / 10 TABLET, FILM... Theraflu ExpressMax Nighttime Severe Cold and Cough Haleon US Holdings LLC 2016-07-05
00363-6156-09 1 KIT in 1 CARTON (0363-6156-09) * 12 TABLET, FILM COATED... Sinus Pressure and Pain Daytime Nighttime Maximum Strength Walgreen Company 2018-06-02
00363-6156-10 1 KIT in 1 CARTON (0363-6156-10) * 12 TABLET, FILM COATED... Sinus Pressure and Pain Daytime Nighttime Maximum Strength Walgreen Company 2018-06-02
11673-0282-09 1 KIT in 1 CARTON (11673-282-09) * 12 TABLET, FILM COATED... Daytime Nighttime Sinus Relief Target Corporation 2024-04-15
11673-0530-02 2 BLISTER PACK in 1 CARTON (11673-530-02) / 1 KIT in 1 BLIS... Daytime Nighttime Sinus Relief Target Corporation 2025-04-06
11822-5694-09 1 KIT in 1 CARTON (11822-5694-9) * 12 TABLET, FILM COATED... Sinus Relief Daytime, Nighttime Rite Aid Corporation 2017-06-16
30142-0616-09 1 KIT in 1 CARTON (30142-616-09) * 12 TABLET, FILM COATED... Sinus Relief Daytime Nighttime Kroger Company 2021-06-01
49035-0356-09 1 KIT in 1 CARTON (49035-356-09) * 10 TABLET, FILM COATED... Day and Night Sinus Wal-Mart Stores Inc 2020-10-23
53145-0009-30 1 BLISTER PACK in 1 BOX (53145-009-30) / 30 TABLET in 1 BLI... Defensol D Blister Pack Menper Distributors, Inc. 2024-01-01
55301-0464-08 2 BLISTER PACK in 1 CARTON (55301-464-08) / 12 TABLET, FILM... Allergy and Sinus Headache ARMY AND AIR FORCE EXCHANGE SERVICE 2005-06-15
69842-0882-09 1 KIT in 1 CARTON (69842-882-09) * 10 TABLET, FILM COATED... Sinus Relief Daytime, Nighttime, Maximum Strength CVS PHARMACY 2017-07-01
79903-0236-20 1 KIT in 1 CARTON (79903-236-20) * 12 TABLET, FILM COATED... Cold and Flu Daytime Nighttime WALMART INC. 2023-12-08
83059-0045-01 1 BOTTLE in 1 PACKAGE (83059-0045-1) / 15 TABLET, FILM COAT... Allergy plus Sinus Headache Shield Pharmaceuticals Corp 2024-09-02
83059-0106-01 1 BLISTER PACK in 1 CARTON (83059-0106-1) / 12 TABLET, FILM... Allergy plus Sinus Headache Shield Pharmaceuticals Corp 2025-11-07
83586-0004-00 32000 TABLET, FILM COATED in 1 BOTTLE (83586-004-00) Acetaminophen, Diphenhydramine Hydrochloride, and Phenylephrine Hydrochloride HHH Pharmaceuticals 2026-06-27
Observed labelers: Haleon US Holdings LLC (2) · Shield Pharmaceuticals Corp (2) · Target Corporation (2) · Walgreen Company (2) · ARMY AND AIR FORCE EXCHANGE SERVICE (1) · CVS PHARMACY (1) · +6 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.