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Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG... — RxCUI 1369842

Name: Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13… (RxCUI 1369842)
Creator: Brian Staiger, PharmD

RxNorm drug concept · Semantic clinical drug

RxCUI 1369842 Semantic clinical drug · SCD ● Current RxNorm concept 86 FDA products 98 package NDCs Snapshot Jul 14, 2026

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1369842

Official nameAcetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution

Concept typeSemantic clinical drug (SCD)

RxNorm statusCurrent RxNorm concept

Also known asacetaminophen 325 MG / dextromethorphan HBr 10 MG / guaifenesin 200 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution; acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG / phenylephrine HCl 5 MG in 15 mL Oral Solution; acetaminophen 650 MG / dextromethorphan HBr 20 MG / guaifenesin 400 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution; APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / Guaifenesin 13.3 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution

FDA products mapped86

Package NDCs mapped98

Reported Medicaid activity (SDUD)15 prescriptions · 1 state & territory Medicaid programs · latest period Q4 2025

RxNorm release07/06/2026

Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist

It depends on the product. The injection raises low blood pressure during anesthesia and, for some products, septic shock. Eye drops dilate the pupil, nasal products relieve conges...
Be careful. Over-the-counter phenylephrine should not be used with a prescription MAOI or within 2 weeks of stopping one. If you aren't sure whether your medicine is an MAOI, ask m...
With the injection, the most common are nausea, vomiting and headache. Call for help right away if you have chest pain, a very slow heartbeat, or pain or skin changes around the IV...
Stop and talk to a doctor if you get nervousness, dizziness or sleeplessness. Also stop if symptoms last more than 7 days or come with a fever. Don't use more than the label recomm...

📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 21.7 MG/ML / dextromethorphan hydr... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.

This page's concept Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution RxCUI 1369842 Semantic clinical drug · SCD

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

Ingredients 7

The active substance itself — no strength, form, or brand attached yet.
- Acetaminophen 161 IN
- Dextromethorphan 3289 IN
- Guaifenesin 5032 IN
- Phenylephrine 8163 IN
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine 689776 MIN
- Dextromethorphan hydrobromide 102490 PIN
- Phenylephrine hydrochloride 8164 PIN
Dose forms 9

The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Solution 647321 SCDF
- Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Solution 2648619 SCDFP
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Liquid Product 1155904 SCDG
- Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Product 1155905 SCDG
- Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Liquid Product 2660160 SCDGP
- Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Product 2662312 SCDGP
- Oral Solution 316968 DF
- Oral Liquid Product 1151137 DFG
- +1 more in this family
Clinical & branded drugs 4

Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
- Acetaminophen 21.7 MG/ML 332581 SCDC
- Dextromethorphan hydrobromide 0.667 MG/ML 1014004 SCDC
- Guaifenesin 13.3 MG/ML 331390 SCDC
- Phenylephrine hydrochloride 0.333 MG/ML 1039296 SCDC
Packs 1

Fixed collections of drugs packaged and sold together, like dose packs.
- {1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution) / 1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution) } Pack 2637731 GPCK

Showing up to 8 concepts per family — 20 of 21 stored related concepts drawn.

These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

{1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution) / 1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution) } Pack GPCK · 2637731
Acetaminophen 21.7 MG/ML SCDC · 332581
Dextromethorphan hydrobromide 0.667 MG/ML SCDC · 1014004
Guaifenesin 13.3 MG/ML SCDC · 331390
Phenylephrine hydrochloride 0.333 MG/ML SCDC · 1039296
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Solution SCDF · 647321
Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Solution SCDFP · 2648619
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Liquid Product SCDG · 1155904
Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Product SCDG · 1155905
Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Liquid Product SCDGP · 2660160

📦 FDA Products & Package NDCs

86 products · 98 package NDCs

98 package NDCs map to RxCUI 1369842 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.

Package NDC	Package	Brand / generic name	Labeler	Marketing start
00067-8132-08	1 SYRUP in 1 BOTTLE (0067-8132-08)	Theraflu ExpressMax Severe Cold and Flu Syrup	Haleon US Holdings LLC	2017-07-07
00113-0603-34	237 mL in 1 BOTTLE (0113-0603-34)	Good Sense Severe Daytime Cold and Flu	L. Perrigo Company	2013-11-19
00113-0603-40	354 mL in 1 BOTTLE (0113-0603-40)	Good Sense Severe Daytime Cold and Flu	L. Perrigo Company	2013-11-19
00113-2299-40	354 mL in 1 BOTTLE (0113-2299-40)	good sense day time cold and flu	L. Perrigo Company	2023-07-05
00113-5970-02	1 KIT in 1 CARTON (0113-5970-02) * 354 mL in 1 BOTTLE (011...	GOODSENSE COMBO PACK DAYTIME AND NIGHTTIME	L. Perrigo Company	2026-02-20
00363-0577-02	1 KIT in 1 CARTON (0363-0577-02) * 355 mL in 1 BOTTLE (036...	daytime nighttime severe cold and flu	Walgreen Company	2015-07-23
00363-0603-34	237 mL in 1 BOTTLE (0363-0603-34)	Severe Cold and Flu	Walgreen Company	2019-04-04
00363-0603-40	355 mL in 1 BOTTLE (0363-0603-40)	Severe Cold and Flu	Walgreen Company	2013-11-21
00363-1597-02	1 KIT in 1 CARTON (0363-1597-02) * 355 mL in 1 BOTTLE (036...	Severe Cold and Flu	Walgreen Company	2014-09-08
00363-4150-08	237 mL in 1 BOTTLE, PLASTIC (0363-4150-08)	Severe Cold and Flu Relief Daytime	Walgreens	2020-07-30
00363-5001-40	355 mL in 1 BOTTLE (0363-5001-40)	daytime severe cold and flu	Walgreen Company	2023-07-08
00363-6105-24	1 KIT in 1 PACKAGE (0363-6105-24) * 354 mL in 1 BOTTLE (03...	Walgreen Day Time NightTime Cold and Flu Relief	WALGREENS CO.	2021-02-10
00363-7270-12	354 mL in 1 BOTTLE, PLASTIC (0363-7270-12)	Daytime Cold and Flu Relief	WALGREENS CO.	2021-02-02
11673-0328-02	1 KIT in 1 CARTON (11673-328-02) * 354 mL in 1 BOTTLE * 3...	Daytime and Nighttime Severe Honey Cold and Flu	TARGET CORPORATION	2024-05-01
11673-0739-02	1 KIT in 1 BOTTLE (11673-739-02) * 355 mL in 1 BOTTLE * 3...	Daytime Severe and Nighttime Severe cold and flu	TARGET CORPORATION	2024-05-01
11673-0791-02	1 KIT in 1 CARTON (11673-791-02) * 354 mL in 1 BOTTLE * 3...	Daytime and Nighttime Severe Honey Cold and Flu	TARGET CORPORATION	2024-05-01
11673-0824-02	1 KIT in 1 BOTTLE (11673-824-02) * 355 mL in 1 BOTTLE * 3...	Daytime Severe and Nighttime Severe cold and flu	TARGET CORPORATION	2024-05-01
11822-0328-01	1 KIT in 1 CARTON (11822-0328-1) * 355 mL in 1 BOTTLE (118...	daytime nighttime severe cold and flu relief	Rite Aid Corporation	2015-07-24
11822-0710-01	355 mL in 1 BOTTLE (11822-0710-1)	Daytime Severe Cold and Flu Relief	Rite Aid Corporation	2014-06-18
11822-3120-00	1 BOTTLE in 1 CARTON (11822-3120-0) / 355 mL in 1 BOTTLE	severe cold and flu relief	Rite Aid Corporation	2023-06-30
21130-0091-40	355 mL in 1 BOTTLE (21130-091-40)	Signature Care Non drowsy Daytime Severe Cold and Flu Relief	Safeway	2016-01-29
21130-0436-40	355 mL in 1 BOTTLE (21130-436-40)	COLD AND FLU RELIEF	Safeway	2026-05-04
30142-0603-40	354 mL in 1 BOTTLE (30142-603-40)	daytime severe cold and flu	Kroger Company	2014-10-10
30142-0722-12	354 mL in 1 BOTTLE, PLASTIC (30142-722-12)	Daytime Cold and Flu Relief	The Kroger Co.	2020-01-28
36800-0597-02	1 KIT in 1 CARTON (36800-597-02) * 355 mL in 1 BOTTLE (368...	Topcare Day Time Nite Time Cold and Flu	Topco Associates LLC	2014-06-28
36800-0603-40	355 mL in 1 BOTTLE (36800-603-40)	Topcare Day Time Cold and Flu	Topco Associates LLC	2014-06-13
37000-0045-24	1 KIT in 1 PACKAGE (37000-045-24) * 354 mL in 1 BOTTLE, PL...	Vicks DayQuil and Vicks NyQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2014-07-31
37000-0810-01	30 mL in 1 BOTTLE, PLASTIC (37000-810-01)	Vicks DayQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2021-07-13
37000-0810-04	4 BOTTLE, PLASTIC in 1 PACKAGE (37000-810-04) / 30 mL in 1...	Vicks DayQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2021-07-13
37000-0810-08	236 mL in 1 BOTTLE, PLASTIC (37000-810-08)	Vicks DayQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2013-07-22
37000-0810-12	354 mL in 1 BOTTLE, PLASTIC (37000-810-12)	Vicks DayQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2013-07-22
37000-0810-24	2 BOTTLE, PLASTIC in 1 CELLO PACK (37000-810-24) / 236 mL i...	Vicks DayQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2024-12-03
37000-0814-24	1 KIT in 1 PACKAGE (37000-814-24) * 354 mL in 1 BOTTLE, PL...	Vicks DayQuil and Vicks NyQuil Severe Cold and Flu	The Procter & Gamble Manufacturing Company	2013-07-22
37808-0603-40	355 mL in 1 BOTTLE (37808-603-40)	daytime severe cold and flu	H E B	2016-04-11
41163-0603-40	1 BOTTLE in 1 CARTON (41163-603-40) / 355 mL in 1 BOTTLE	equaline daytime severe cold and flu relief	United Natural Foods, Inc. dba UNFI	2014-07-28
41226-0766-01	354 mL in 1 BOTTLE (41226-766-01)	Severe Cold and Flu Daytime Honey	Kroger	2024-04-30
41226-0774-01	354 mL in 1 BOTTLE (41226-774-01)	Daytime Severe Cold and Flu	Kroger	2024-04-30
41226-0776-02	2 BOTTLE in 1 CARTON (41226-776-02) / 1 KIT in 1 BOTTLE *...	Severe Cold and Flu Daytime and Nighttime	Kroger	2026-04-01
41226-0780-01	354 mL in 1 BOTTLE (41226-780-01)	Severe Cold and Flu Daytime	KROGER COMPANY	2024-04-30
41250-0597-02	1 KIT in 1 KIT (41250-597-02) * 355 mL in 1 BOTTLE (41250-...	NiteTime DayTime Cold and Flu	Meijer Distribution Inc	2013-12-30
41250-0603-40	355 mL in 1 BOTTLE (41250-603-40)	Daytime Cold and Flu	Meijer Distribution Inc	2013-12-11
41250-0919-02	1 KIT in 1 CARTON (41250-919-02) * 355 mL in 1 BOTTLE (412...	DAYTIME COLD AND FLU NITETIME COLD AND FLU	Meijer Distribution Inc	2019-03-29
41520-0713-40	355 mL in 1 BOTTLE (41520-713-40)	Careone daytime severe cold and flu	American Sales Company	2016-05-24
42507-0511-40	355 mL in 1 BOTTLE (42507-511-40)	severe cold and flu	HyVee Inc	2026-01-28
42507-0597-02	1 KIT in 1 CARTON (42507-597-02) * 355 mL in 1 BOTTLE * 3...	Severe Cold and Flu Nighttime Daytime	HyVee Inc	2014-05-19
42507-0603-40	355 mL in 1 BOTTLE (42507-603-40)	Severe Cold and Flu	HyVee Inc	2014-01-12
49035-0476-40	355 mL in 1 BOTTLE (49035-476-40)	equate daytime cold and flu	Wal-Mart Stores Inc	2019-09-24
49035-0714-02	1 KIT in 1 CARTON (49035-714-02) * 355 mL in 1 BOTTLE (490...	Equate Daytime Nighttime Cold and Flu	Wal-Mart Stores Inc	2020-03-18
49580-0415-08	237 mL in 1 BOTTLE, PLASTIC (49580-0415-8)	Severe Cold and Flu Relief Daytime	P & L Development, LLC	2021-03-26
50580-0231-01	1 KIT in 1 PACKAGE (50580-231-01) * 240 mL in 1 BOTTLE, PL...	TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack	Kenvue Brands LLC	2018-08-20

Observed labelers: The Procter & Gamble Manufacturing Company (13) · Amazon.com Services LLC (7) · Kenvue Brands LLC (6) · Procter & Gamble Manufacturing Company (5) · Target Corporation (5) · Walgreen Company (5) · +28 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7

openFDA export observedJul 14, 2026

RxNorm release07/06/2026

Methodology2026-07-full-catalog-v1

A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.

This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.