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Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG... — RxCUI 1546881

RxNorm drug concept · Semantic clinical drug
RxCUI 1546881 Semantic clinical drug · SCD ● Current RxNorm concept 26 FDA products 27 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1546881
Official nameAcetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Tablet
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / Dextromethorphan Hydrobromide 10 MG / doxylamine succinate 6.25 MG / Phenylephrine Hydrochloride 5 MG Oral Tablet; acetaminophen 325 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine HCl 5 MG Oral Tablet
FDA products mapped26
Package NDCs mapped27
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • It depends on the product. The injection raises low blood pressure during anesthesia and, for some products, septic shock. Eye drops dilate the pupil, nasal products relieve conges...
  • Be careful. Over-the-counter phenylephrine should not be used with a prescription MAOI or within 2 weeks of stopping one. If you aren't sure whether your medicine is an MAOI, ask m...
  • With the injection, the most common are nausea, vomiting and headache. Call for help right away if you have chest pain, a very slow heartbeat, or pain or skin changes around the IV...
  • Stop and talk to a doctor if you get nervousness, dizziness or sleeplessness. Also stop if symptoms last more than 7 days or come with a fever. Don't use more than the label recomm...
📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 325 MG / dextromethorphan hydrobro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Tablet RxCUI 1546881

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 8

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Dextromethorphan 3289
    • Doxylamine 3642
    • Phenylephrine 8163
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine 1008701
    • Dextromethorphan hydrobromide 102490
    • Doxylamine succinate 23665
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Tablet 1546875
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Tablet 2648526
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product 1155896
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Pill 1297772
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Product 2660518
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Pill 2661266
    • Oral Tablet 317541
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Dextromethorphan hydrobromide 10 MG 1014455
    • Doxylamine succinate 6.25 MG 1052646
    • Phenylephrine hydrochloride 5 MG 1020198
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 21 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

26 products · 27 package NDCs
27 package NDCs map to RxCUI 1546881 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-6406-08 1 KIT in 1 PACKAGE, COMBINATION (0363-6406-08) * 8 TABLET,... Cold and Flu Daytime, Nighttime, Maximum Strength Walgreen Company 2015-08-01
00363-6406-22 1 KIT in 1 PACKAGE, COMBINATION (0363-6406-22) * 8 TABLET,... Cold and Flu Daytime, Nighttime, Maximum Strength Walgreen Company 2015-08-01
11822-0677-08 2 BLISTER PACK in 1 CARTON (11822-0677-8) / 12 TABLET, FILM... Severe Nighttime Cold and Flu Relief Rite Aid Corporation 2019-12-10
29485-5053-06 6 BLISTER PACK in 1 CARTON (29485-5053-6) / 6 TABLET, FILM... Cold and Flu Nighttime Severe Lil' Drug Store Products, Inc. 2021-10-27
36800-0307-62 12 BLISTER PACK in 1 CARTON (36800-307-62) / 2 TABLET, FILM... topcare nite time cold and flu Topco Associates LLC 2019-09-10
37000-0523-02 2 TABLET, COATED in 1 POUCH (37000-523-02) NyQuil Severe plus Vicks VapoCool Cold and Flu The Procter & Gamble Manufacturing Company 2018-08-01
41250-0840-22 1 KIT in 1 CARTON (41250-840-22) * 8 TABLET, FILM COATED i... DayTime/NiteTime Severe Cold and Flu Maximum Strength Meijer Distribution Inc 2015-08-01
41250-0877-08 2 BLISTER PACK in 1 CARTON (41250-877-08) / 12 TABLET, FILM... Nite time Severe Cold and Flu Maximum Strength Meijer Distribution Inc 2015-08-01
49035-0708-62 12 BLISTER PACK in 1 CARTON (49035-708-62) / 2 TABLET, FILM... equate vapor ice cold and flu Wal-Mart Stores Inc 2020-07-14
49035-0796-02 1 KIT in 1 CARTON (49035-796-02) * 8 BLISTER PACK in 1 KIT... Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu Wal-Mart Stores Inc 2020-07-14
50844-0677-21 2 BLISTER PACK in 1 CARTON (50844-677-21) / 8 TABLET, FILM... Cold and Flu Nighttime Severe L.N.K. International, Inc. 2022-02-07
51316-0647-22 1 KIT in 1 CARTON (51316-647-22) * 8 TABLET, FILM COATED i... Daytime, Nighttime Severe Cold and Flu Relief CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED 2022-11-03
55301-0620-08 1 KIT in 1 CARTON (55301-620-08) * 8 TABLET, FILM COATED i... Severe Cold and Flu Relief Daytime/Nighttime ARMY AND AIR FORCE EXCHANGE SERVICE 2018-08-31
55910-0643-90 1 KIT in 1 CARTON (55910-643-90) * 2 TABLET, FILM COATED i... dg health day time severe cold and flu relief night time severe cold and flu relief Dolgencorp, LLC 2021-05-26
63981-0795-81 14 BLISTER PACK in 1 CARTON (63981-795-81) / 1 KIT in 1 BLI... Severe Cold and Flu Plus Congestion COSTCO WHOLESALE CORPORATION 2023-06-30
66715-6405-02 2 POUCH in 1 CARTON (66715-6405-2) / 2 TABLET, COATED in 1... NyQuil Severe Plus VapoCOOL Cold and Flu, TRAVEL BASIX Lil' Drug Store Products, Inc. 2022-11-29
66715-6505-03 1 BLISTER PACK in 1 CARTON (66715-6505-3) / 6 TABLET, FILM... Nighttime Severe, Cold and Flu, 24-7 Life by 7-Eleven Lil' Drug Store Products, Inc. 2022-02-06
66715-6516-08 2 BLISTER PACK in 1 CARTON (66715-6516-8) / 8 TABLET, FILM... Cold and Flu Nighttime Severe, 24-7 Life Lil' Drug Store products, Inc. 2022-04-19
66715-6581-02 2 POUCH in 1 CARTON (66715-6581-2) / 2 TABLET, COATED in 1... NyQuil Severe Plus VapoCOOL Cold and Flu, CVP HEALTH Lil' Drug Store Products, Inc. 2022-08-01
66715-9905-02 2 POUCH in 1 CARTON (66715-9905-2) / 2 TABLET, COATED in 1... NyQuil Severe Plus VapoCOOL Cold and Flu Lil' Drug Store Products, Inc. 2019-05-01
69423-0986-24 1 BLISTER PACK in 1 CARTON (69423-986-24) / 24 TABLET, COAT... Vicks NyQuil VapoCOOL Severe COLD and FLU plus CONGESTION The Procter & Gamble Manufacturing Company 2021-03-22
69423-0988-24 1 KIT in 1 PACKAGE (69423-988-24) * 1 TABLET in 1 BLISTER... Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION The Procter & Gamble Manufacturing Company 2021-03-22
69423-0988-48 1 KIT in 1 PACKAGE (69423-988-48) * 1 TABLET in 1 BLISTER... Vicks DayQuil and Nyquil VapoCOOL Severe COLD and FLU plus CONGESTION The Procter & Gamble Manufacturing Company 2021-03-22
72288-0002-90 1 KIT in 1 CARTON (72288-002-90) * 2 TABLET, FILM COATED i... basic care daytime severe cold and flu nighttime severe cold and flu Amazon.com Services LLC 2021-02-04
72288-0502-72 1 KIT in 1 CARTON (72288-502-72) * 2 TABLET, FILM COATED i... basic care daytime severe cold and flu nighttime cold and flu Amazon.com Services LLC 2021-08-05
72288-0721-62 12 BLISTER PACK in 1 CARTON (72288-721-62) / 2 TABLET, FILM... basic care nighttime severe cold and flu Amazon.com Services LLC 2020-12-10
79481-5200-00 1 KIT in 1 CARTON (79481-5200-0) * 2 TABLET, FILM COATED i... daytime cold and flu nighttime cold and flu Meijer, Inc. 2021-08-21
Observed labelers: Lil' Drug Store Products, Inc. (6) · The Procter & Gamble Manufacturing Company (4) · Amazon.com Services LLC (3) · Meijer Distribution Inc (2) · Wal-Mart Stores Inc (2) · Walgreen Company (2) · +8 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.