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{1 (acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution) / 1... — RxCUI 2681010

RxNorm drug concept · Generic pack
RxCUI 2681010 Generic pack · GPCK ● Current RxNorm concept 4 FDA products 5 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI2681010
Official name{1 (acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution) / 1 (acetaminophen 33.3 MG/ML Oral Solution) } Pack
Concept typeGeneric pack (GPCK)
RxNorm statusCurrent RxNorm concept
Also known as1 nighttime (acetaminophen 1000 MG / diphenhydramine HCl 50 MG per 30 mL Oral Solution) / 1 daytime (acetaminophen 1000 MG per 30 mL Oral Solution) Pack; 1 nighttime (acetaminophen 1000 MG / diphenhydrAMINE HCl 50 MG in 30 mL Oral Solution) / 1 daytime (acetaminophen 1000 MG in 30 mL Oral Solution) Pack
FDA products mapped4
Package NDCs mapped5
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How {1 (acetaminophen 33.3 MG/ML / diphenhydramine h... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept {1 (acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution) / 1 (acetaminophen 33.3 MG/ML Oral Solution) } Pack RxCUI 2681010

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Acetaminophen / diphenhydramine 214181
    • Diphenhydramine hydrochloride 1362
  2. Brand names 4

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Comtrex Sore Throat Relief 707319
    • Mapap 218205
    • Redutemp 219598
    • Tylenol PM 220581
  3. Dose forms 25

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine Oral Solution 371897
    • Acetaminophen Oral Solution 370506
    • Acetaminophen / diphenhydramine hydrochloride Oral Solution 2648062
    • Acetaminophen / diphenhydramine Oral Liquid Product 1151203
    • Acetaminophen / diphenhydramine Oral Product 1151204
    • Acetaminophen Oral Liquid Product 1152841
    • Acetaminophen Oral Product 1152842
    • Acetaminophen / diphenhydramine hydrochloride Oral Liquid Product 2660960
    • +17 more in this family
  4. Clinical & branded drugs 12

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 24 of 45 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution SCD · 1092373
  • Acetaminophen 33.3 MG/ML Oral Solution SCD · 307684
  • Acetaminophen 33.3 MG/ML SCDC · 328877
  • Diphenhydramine hydrochloride 1.67 MG/ML SCDC · 1092372
  • Acetaminophen / diphenhydramine Oral Solution SCDF · 371897
  • Acetaminophen Oral Solution SCDF · 370506
  • Acetaminophen / diphenhydramine hydrochloride Oral Solution SCDFP · 2648062
  • Acetaminophen / diphenhydramine Oral Liquid Product SCDG · 1151203
  • Acetaminophen / diphenhydramine Oral Product SCDG · 1151204
  • Acetaminophen Oral Liquid Product SCDG · 1152841

Brand-Name Concepts

  • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Tylenol PM] SBD · 1092375
  • Acetaminophen 33.3 MG/ML Oral Solution [Comtrex Sore Throat Relief] SBD · 707322
  • Acetaminophen 33.3 MG/ML Oral Solution [Mapap] SBD · 209417
  • Acetaminophen 33.3 MG/ML Oral Solution [Redutemp] SBD · 209425
  • Acetaminophen 33.3 MG/ML [Comtrex Sore Throat Relief] SBDC · 707320
  • Acetaminophen 33.3 MG/ML [Mapap] SBDC · 570028
  • Acetaminophen 33.3 MG/ML [Redutemp] SBDC · 570036
  • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML [Tylenol PM] SBDC · 1092374
  • Acetaminophen / diphenhydramine Oral Solution [Tylenol PM] SBDF · 604823
  • Acetaminophen Oral Solution [Comtrex Sore Throat Relief] SBDF · 707321

📦 FDA Products & Package NDCs

4 products · 5 package NDCs
5 package NDCs map to RxCUI 2681010 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-8757-02 1 KIT in 1 PACKAGE (0363-8757-02) * 354 mL in 1 BOTTLE (03... Acetaminophen Liquid / Acetaminophen Diphenhydramine HCl Liquid WALGREENS 2025-12-15
41226-0672-02 1 KIT in 1 PACKAGE (41226-672-02) * 354 mL in 1 BOTTLE (41... Acetaminophen Liquid / Acetaminophen Diphenhydramine HCl Liquid Kroger 2026-06-01
69423-0849-24 1 KIT in 1 PACKAGE (69423-849-24) * 354 mL in 1 BOTTLE *... Vicks PainQuil and Vicks PainQuil PM PAIN RELIEVER The Procter & Gamble Manufacturing Company 2024-05-07
69423-0849-36 1 KIT in 1 PACKAGE (69423-849-36) * 354 mL in 1 BOTTLE *... Vicks PainQuil and Vicks PainQuil PM PAIN RELIEVER The Procter & Gamble Manufacturing Company 2025-03-17
84126-0351-24 1 KIT in 1 PACKAGE (84126-351-24) * 354 mL in 1 BOTTLE (84... Vicks PainQuil and Vicks PainQuil PM PAIN RELIEVER The Procter & Gamble Manufacturing Company 2025-05-06
Observed labelers: The Procter & Gamble Manufacturing Company (3) · Kroger (1) · WALGREENS (1) — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.