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Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution — RxCUI 1092373

RxNorm drug concept · Semantic clinical drug
RxCUI 1092373 Semantic clinical drug · SCD ● Current RxNorm concept 15 FDA products 19 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1092373
Official nameAcetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 33.3 MG/ML / Diphenhydramine Hydrochloride 1.67 MG/ML Oral Solution; acetaminophen 500 MG / diphenhydrAMINE HCl 25 MG in 15 mL Oral Solution; acetaminophen 1000 MG / diphenhydramine HCl 50 MG per 30 ML Oral Solution; acetaminophen 500 MG / diphenhydramine HCl 25 MG per 15 ML Oral Solution
FDA products mapped15
Package NDCs mapped19
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Acetaminophen 33.3 MG/ML / diphenhydramine hydro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution RxCUI 1092373

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Diphenhydramine 3498
    • Acetaminophen / diphenhydramine 214181
    • Diphenhydramine hydrochloride 1362
  2. Brand names 1

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Tylenol PM 220581
  3. Dose forms 13

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / diphenhydramine Oral Solution 371897
    • Acetaminophen / diphenhydramine hydrochloride Oral Solution 2648062
    • Acetaminophen / diphenhydramine Oral Liquid Product 1151203
    • Acetaminophen / diphenhydramine Oral Product 1151204
    • Acetaminophen / diphenhydramine hydrochloride Oral Liquid Product 2660960
    • Acetaminophen / diphenhydramine hydrochloride Oral Product 2662609
    • Acetaminophen / diphenhydramine Oral Solution [Tylenol PM] 604823
    • Acetaminophen / diphenhydramine hydrochloride Oral Solution [Tylenol PM] 2657845
    • +5 more in this family
  4. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 33.3 MG/ML 328877
    • Diphenhydramine hydrochloride 1.67 MG/ML 1092372
    • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Tylenol PM] 1092375
    • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML [Tylenol PM] 1092374
  5. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 18 of 23 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

Brand-Name Concepts

  • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Tylenol PM] SBD · 1092375
  • Acetaminophen 33.3 MG/ML / diphenhydramine hydrochloride 1.67 MG/ML [Tylenol PM] SBDC · 1092374
  • Acetaminophen / diphenhydramine Oral Solution [Tylenol PM] SBDF · 604823
  • Acetaminophen / diphenhydramine hydrochloride Oral Solution [Tylenol PM] SBDFP · 2657845
  • Tylenol PM Oral Liquid Product SBDG · 1187312
  • Tylenol PM Oral Product SBDG · 1187313
  • Tylenol PM BN · 220581

📦 FDA Products & Package NDCs

15 products · 19 package NDCs
19 package NDCs map to RxCUI 1092373 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-8757-02 1 KIT in 1 PACKAGE (0363-8757-02) * 354 mL in 1 BOTTLE (03... Acetaminophen Liquid / Acetaminophen Diphenhydramine HCl Liquid WALGREENS 2025-12-15
00363-9074-02 355 mL in 1 BOTTLE, PLASTIC (0363-9074-02) Sleep Aid Plus Pain Relief Walgreen Company 2022-08-27
11822-8791-01 354 mL in 1 BOTTLE (11822-8791-1) RiteAid Nighttime Sleep Aid RITE AID CORPORATION 2021-06-01
30142-0093-02 355 mL in 1 BOTTLE, PLASTIC (30142-093-02) Pain Reliever plus Sleep Aid NightTime Kroger Company 2024-04-22
37000-0598-12 354 mL in 1 BOTTLE (37000-598-12) Vicks ZzzQuil NIGHT PAIN NIGHTTIME SLEEP-AID PAIN RELIEVER The Procter & Gamble Manufacturing Company 2020-06-01
37000-0598-24 2 BOTTLE in 1 CARTON (37000-598-24) / 354 mL in 1 BOTTLE Vicks ZzzQuil NIGHT PAIN NIGHTTIME SLEEP-AID PAIN RELIEVER The Procter & Gamble Manufacturing Company 2020-06-01
41226-0672-02 1 KIT in 1 PACKAGE (41226-672-02) * 354 mL in 1 BOTTLE (41... Acetaminophen Liquid / Acetaminophen Diphenhydramine HCl Liquid Kroger 2026-06-01
69423-0834-12 354 mL in 1 BOTTLE (69423-834-12) Vicks PainQuil PM PAIN RELIEVER plus NIGHTTIME SLEEP-AID The Procter & Gamble Manufacturing Company 2024-05-07
69423-0849-24 1 KIT in 1 PACKAGE (69423-849-24) * 354 mL in 1 BOTTLE *... Vicks PainQuil and Vicks PainQuil PM PAIN RELIEVER The Procter & Gamble Manufacturing Company 2024-05-07
69423-0849-36 1 KIT in 1 PACKAGE (69423-849-36) * 354 mL in 1 BOTTLE *... Vicks PainQuil and Vicks PainQuil PM PAIN RELIEVER The Procter & Gamble Manufacturing Company 2025-03-17
69423-0985-02 2 BOTTLE in 1 CARTON (69423-985-02) / 354 mL in 1 BOTTLE Vicks ZzzQuil Night Pain The Procter & Gamble Manufacturing Company 2023-03-03
69423-0985-12 354 mL in 1 BOTTLE (69423-985-12) Vicks ZzzQuil Night Pain The Procter & Gamble Manufacturing Company 2023-03-03
69842-0448-12 354 mL in 1 BOTTLE (69842-448-12) CVS Nighttime Sleep Aid CVS PHARMACY 2021-02-12
79903-0099-02 355 mL in 1 BOTTLE, PLASTIC (79903-099-02) Nighttime Pain Reliever plus Sleep Aid WALMART INC. 2022-01-12
79903-0421-12 355 mL in 1 BOTTLE (79903-421-12) equate pain relief pm WALMART INC. 2026-04-29
84126-0350-12 354 mL in 1 BOTTLE (84126-350-12) Vicks PainQuil PM PAIN RELIEVER plus NIGHTTIME SLEEP-AID The Procter & Gamble Manufacturing Company 2025-05-06
84126-0351-24 1 KIT in 1 PACKAGE (84126-351-24) * 354 mL in 1 BOTTLE (84... Vicks PainQuil and Vicks PainQuil PM PAIN RELIEVER The Procter & Gamble Manufacturing Company 2025-05-06
84126-0372-12 354 mL in 1 BOTTLE (84126-372-12) Vicks ZzzQuil NIGHT PAIN NIGHTTIME SLEEP-AID PAIN RELIEVER The Procter & Gamble Manufacturing Company 2026-02-03
84126-0372-24 2 BOTTLE in 1 CARTON (84126-372-24) / 354 mL in 1 BOTTLE Vicks ZzzQuil NIGHT PAIN NIGHTTIME SLEEP-AID PAIN RELIEVER The Procter & Gamble Manufacturing Company 2026-02-03
Observed labelers: The Procter & Gamble Manufacturing Company (11) · WALMART INC. (2) · CVS PHARMACY (1) · Kroger (1) · Kroger Company (1) · RITE AID CORPORATION (1) · +2 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.