Insulin Lispro Protamine And Insulin Lispro Injection shortage
Insulin Lispro Protamine And Insulin Lispro Injection is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Sep 25, 2026.
Eli Lilly is stopping production of insulin lispro protamine and insulin lispro injection, and this change is permanent. Humalog Mix75/25 (insulin lispro) 100 units/mL injection is still listed by Eli Lilly as an available product.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Insulin Lispro Protamine And Insulin Lispro Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Sep 1, 2026Currently in shortage1 of 1 product affected.
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Sep 1, 2026First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Eli Lilly and Co. 📞 800-545-5979 1 NDC click to expand
| Status | NDC / product | Size | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Humalog Mix 75/25, Injection, 100 [iU]/1 mL (NDC 0002-8233-05) | — | — | A business decision was made to discontinue manufacture of the drug. Distribution projected to end June 2027. If patients or prescribers have any questions, the Lilly Answers Center (1-800-545-5979) is available Monday through Friday from 9am to 8pm for assistance. | — |
These rows are manufacturer reports to the FDA for Insulin Lispro Protamine And Insulin Lispro Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Insulin Lispro Protamine And Insulin Lispro Injection? options further down this page.
Why is Insulin Lispro Protamine And Insulin Lispro Injection in shortage?
Eli Lilly has made a business decision to permanently stop making Humalog Mix 75/25 (insulin lispro protamine and insulin lispro) 100 units/mL. This isn't due to a manufacturing problem or safety issue — it's simply a business choice the company made. According to the FDA report, Lilly expects distribution of this product to continue through June 2027, so it won't disappear right away.
It's worth knowing that this report covers only Eli Lilly's version of this specific product. Other manufacturers of insulin products are listed separately and are not part of this particular report.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Insulin Lispro Protamine And Insulin Lispro Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Insulin Lispro Protamine And Insulin Lispro Injection?
Insulin Lispro Protamine and Insulin Lispro Injection (the mixed insulin sold as Humalog Mix 75/25) is currently on the FDA shortage list, and the report notes it is being discontinued.
This shortage record covers one strength, 100 iU/1 mL, which has no available source reported right now. Because there is only this single strength, there is no separate version still in supply on this record. The reason given is a business decision by the manufacturer to stop making the product, with distribution projected to end June 2027. Since this is a discontinuation rather than a temporary supply gap, the change may be permanent, which makes a conversation with your prescriber especially important.
Please take these steps in order:
- Do not stop, skip, or change your insulin doses on your own — insulin needs stay steady.
- Ask your pharmacy to check wholesalers and other manufacturers; our records still list Humalog Mix 75/25 (insulin lispro, 100 iU/mL) from Eli Lilly, though it may not be in local stock.
- Because this product is being discontinued, ask your prescriber or pharmacist soon about a clinician-chosen alternative.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls. This is national, manufacturer-reported information and may not match your pharmacy's actual stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Where else can I get Insulin Lispro Protamine And Insulin Lispro Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Insulin Lispro Protamine And Insulin Lispro Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Humalog Mix75/25 | INSULIN LISPRO 100 [iU]/mL | Injection, Suspension · Subcutaneous | Eli Lilly and Company | 00002-7511-01 |
Therapeutic equivalents & pricing 7 productsclick to expand
Orange Book–rated equivalents of the affected sizes, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Humalog Mix75/25 100 [iU]/mL | Eli | 1 vial | $8.153 | — | Availability likely |
| Humalog Tempo Pen 100 [iU]/mL | Eli | 5 syringes | $10.127 | — | Availability likely |
| Humalog Mix50/50 KwikPen 100 [iU]/mL | Eli | 5 syringes | $10.141 | — | Availability likely |
| Humalog Junior KwikPen 100 [iU]/mL | Eli | 5 syringes | $10.158 | — | Availability likely |
| Humalog Mix75/25 KwikPen 100 [iU]/mL | Eli | 5 syringes | $10.167 | — | Availability likely |
| Insulin Lispro Junior KwikPen 100 [iU]/mL | Eli | 5 syringes | $10.199 | — | Availability likely |
| Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 KwikPen 100 [iU]/mL | Eli | 5 syringes | $10.207 | — | Availability likely |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Insulin Lispro Protamine And Insulin Lispro Injection — that fall in the same broad treatment class (insulins) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other endocrinology/metabolism shortages
Insulin Lispro Protamine And Insulin Lispro Injection shortage FAQs
Is Insulin Lispro Protamine And Insulin Lispro Injection in shortage?
Which products are affected?
When will Insulin Lispro Protamine And Insulin Lispro Injection be available again?
Can I still get Insulin Lispro Protamine And Insulin Lispro somewhere?
What should I do if I take Insulin Lispro Protamine And Insulin Lispro Injection?
Still have a question about the Insulin Lispro Protamine And Insulin Lispro Injection shortage?
Ask a pharmacist about this shortage →View Insulin Lispro Protamine And Insulin Lis... on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.