Pentamidine Isethionate Injection shortage
Pentamidine Isethionate Injection is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Sep 22, 2026.
XGen Pharmaceuticals is permanently stopping production of its pentamidine isethionate injection 300 mg/3 mL. Other makers — including the brand Pentam 300 — still list this medicine as available.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Pentamidine Isethionate Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Mar 23, 2026Currently in shortage1 of 1 product affected.
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Mar 23, 2026First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: XGen Pharmaceuticals DJB, Inc. 📞 866-390-4411 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Pentamidine Isethionate, Injection, 300 mg/3 mL (NDC 39822-3050-2) | — | — | A business decision was made to discontinue manufacture of the drug. | — |
These rows are manufacturer reports to the FDA for Pentamidine Isethionate Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Pentamidine Isethionate Injection? options further down this page.
Why is Pentamidine Isethionate Injection in shortage?
XGen Pharmaceuticals DJB, Inc. has made a business decision to permanently stop making their version of Pentamidine Isethionate Injection 300 mg/3 mL (the specific vial size reported here). They didn't share a detailed public explanation beyond it being a business decision on their part — so unfortunately there's no more specific "why" available in this report.
It's worth knowing that this report covers only XGen Pharmaceuticals DJB, Inc. and their 300 mg/3 mL presentation specifically. Other manufacturers of this medication may have their own separate listings on the FDA shortage page.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Pentamidine Isethionate Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Pentamidine Isethionate Injection?
Pentamidine Isethionate Injection is currently on the FDA shortage list, and I want to walk you through what that means for you.
The one strength on this report, 300 mg/3 mL, has no available source from the manufacturer that filed this report. There are no other strengths to separate out here — this record covers a single strength.
The reason given is straightforward: the manufacturer, XGen Pharmaceuticals, made a business decision to stop making this product. Because the status is listed as "to be discontinued," this particular supply problem may be permanent rather than temporary. That makes a conversation with your prescriber or pharmacist the right next step. Importantly, this report reflects only that one manufacturer — the same medicine may still be available from other makers.
Here is what I suggest:
- Do not stop, skip, or change your treatment on your own.
- Ask your pharmacy to check wholesalers and other suppliers, since the same medicine (pentamidine isethionate injection) is still listed from other makers, including PAI Pharma, Seton Pharmaceuticals, Avet Pharmaceuticals, and Fresenius Kabi (Pentam 300). Your pharmacy may be able to source one of these, though it may not be in local stock.
- If your exact product cannot be found, ask your prescriber or pharmacist about a clinician-chosen option.
A manufacturer contact number is listed on this page for reference; pharmacies usually handle those calls. This is general, national information and may not match your local pharmacy's actual stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Pentamidine Isethionate Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Pentamidine Isethionate Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Pentamidine Isethionate | PENTAMIDINE DIISETHIONATE 300 mg/300mg | Injection, Powder, Lyophilized, For Solution · Intramuscular, Intravenous | PAI Holdings, LLC dba PAI Pharma | 00121-1101-02 |
| Pentamidine Isethionate | PENTAMIDINE ISETHIONATE 300 mg/300mg | Injection, Powder, Lyophilized, For Solution · Intramuscular, Intravenous | Seton Pharmaceuticals | 13925-0515-10 |
| Pentamidine Isethionate | PENTAMIDINE ISETHIONATE 300 mg/300mg | Injection, Powder, Lyophilized, For Solution · Intramuscular, Intravenous | Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. | 23155-0748-41 |
| Pentam 300 | PENTAMIDINE ISETHIONATE 300 mg/3mL | Injection, Powder, Lyophilized, For Solution · Intramuscular, Intravenous | Fresenius Kabi USA, LLC | 63323-0113-10 |
Alternative dosage forms of Pentamidine Isethionate
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 5 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Pentamidine Isethionate 300 mg/300mg | PAI | 10 vials | — | AP | FDA listed |
| Pentamidine Isethionate 300 mg/300mg | Seton | 10 vials | — | AP | FDA listed |
| pentamidine isethionate 300 mg/300mg | Heritage | 10 vials | — | AP | FDA listed |
| Pentamidine Isethionate 300 mg/3mL | XGen | 10 vials | — | — | FDA listed |
| Pentam 300 300 mg/3mL | Fresenius | 10 vials | — | AP | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Pentamidine Isethionate Injection — that fall in the same broad treatment class (antiprotozoal drugs,miscellaneous) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other anti-infective shortages
Pentamidine Isethionate Injection shortage FAQs
Is Pentamidine Isethionate Injection in shortage?
Which products are affected?
When will Pentamidine Isethionate Injection be available again?
Can I still get Pentamidine Isethionate somewhere?
What should I do if I take Pentamidine Isethionate Injection?
Still have a question about the Pentamidine Isethionate Injection shortage?
Ask a pharmacist about this shortage →View Pentamidine Isethionate Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.