Piperacillin And Tazobactam Injection shortage
Piperacillin And Tazobactam Injection is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Sep 23, 2026.
Fresenius Kabi is permanently stopping its piperacillin-tazobactam injection 2.25 g vials. Other manufacturers — including B. Braun Medical, Sagent Pharmaceuticals, WG Critical Care, and Eugia — still list piperacillin-tazobactam in multiple strengths and forms.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Piperacillin And Tazobactam Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Jan 20, 2026Currently in shortage1 of 1 product affected.
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Jan 20, 2026First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Fresenius Kabi USA, LLC 📞 888-386-1300 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Piperacillin and Tazobactam, Injection, 2.25 g vial (NDC 65219-434-20) | — | — | Discontinuation of the manufacture of the drug | — |
These rows are manufacturer reports to the FDA for Piperacillin And Tazobactam Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Piperacillin And Tazobactam Injection? options further down this page.
Why is Piperacillin And Tazobactam Injection in shortage?
Fresenius Kabi USA has reported to the FDA that they are permanently stopping the manufacture of their 2.25 g vial of Piperacillin and Tazobactam Injection (NDC 65219-434-20). In other words, this specific product from this specific company is not going away temporarily — it's a permanent decision to stop making that particular vial size altogether.
No specific reason was shared publicly with the FDA for why they made this decision. It's worth knowing that this report only covers Fresenius Kabi's 2.25 g vial — it does not speak to what other manufacturers may or may not be doing with their own versions of this antibiotic.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Piperacillin And Tazobactam Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Piperacillin And Tazobactam Injection?
Piperacillin and tazobactam injection is currently on the FDA shortage list, and I want to walk you through what this means for the strength you may be using.
The affected strength is the 2.25 g vial, which right now has no available source. The manufacturer that filed this report, Fresenius Kabi USA, has listed this vial as being discontinued. Because this is a discontinuation rather than a temporary delay, the supply problem for this specific product may be permanent.
It's important to know that this report reflects only the one manufacturer that filed it. The same medicine — piperacillin and tazobactam — is still listed by several other makers, including B. Braun Medical, Sagent, WG Critical Care, Eugia US, and Apotex, in various strengths and forms. These are the same active ingredients from a different maker, though they may not be sitting in local stock.
Here is what I suggest, in order:
- Do not stop, skip, or change your treatment on your own.
- Ask your pharmacy to check wholesalers and other manufacturers, since this same medicine is still made by other companies.
- Because your exact vial is being discontinued, talk with your prescriber or pharmacist about a suitable option, such as another strength or a clinician-chosen alternative.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls. This is general, national information and may not match your local pharmacy's actual stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Piperacillin And Tazobactam Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Piperacillin And Tazobactam Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Piperacillin And Tazobactam And Sodium Chloride | TAZOBACTAM SODIUM 250 mg/50mL; PIPERACILLIN SODIUM 2 g/50mL | Injection, Solution · Intravenous | B. Braun Medical Inc. | 00264-3446-11 |
| Piperacillin And Tazobactam And Sodium Chloride | TAZOBACTAM SODIUM 375 mg/50mL; PIPERACILLIN SODIUM 3 g/50mL | Injection, Solution · Intravenous | B. Braun Medical Inc. | 00264-3448-11 |
| Piperacillin And Tazobactam And Sodium Chloride | TAZOBACTAM SODIUM 500 mg/100mL; PIPERACILLIN SODIUM 4 g/100mL | Injection, Solution · Intravenous | B. Braun Medical Inc. | 00264-3450-22 |
| Piperacillin, Tazobactam | PIPERACILLIN SODIUM 36 g/152mL; TAZOBACTAM SODIUM 4.5 g/152mL | Injection, Powder, Lyophilized, For Solution · Intravenous | Sagent Pharmaceuticals | 25021-0181-99 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 2 g/1; TAZOBACTAM SODIUM .25 g/1 | Injection, Powder, For Solution · Intravenous | WG Critical Care, LLC | 44567-0801-10 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 3 g/1; TAZOBACTAM SODIUM .375 g/1 | Injection, Powder, For Solution · Intravenous | WG Critical Care, LLC | 44567-0802-10 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 4 g/1; TAZOBACTAM SODIUM .5 g/1 | Injection, Powder, For Solution · Intravenous | WG Critical Care, LLC | 44567-0803-10 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 36 g/1; TAZOBACTAM SODIUM 4.5 g/1 | Injection, Powder, For Solution · Intravenous | WG Critical Care, LLC | 44567-0804-01 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 2 g/1; TAZOBACTAM SODIUM .25 g/1 | Injection, Powder, Lyophilized, For Solution · Intravenous | Eugia US LLC | 55150-0119-09 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 3 g/1; TAZOBACTAM SODIUM .375 g/1 | Injection, Powder, Lyophilized, For Solution · Intravenous | Eugia US LLC | 55150-0120-09 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 4 g/1; TAZOBACTAM SODIUM .5 g/1 | Injection, Powder, Lyophilized, For Solution · Intravenous | Eugia US LLC | 55150-0121-09 |
| Piperacillin And Tazobactam | PIPERACILLIN SODIUM 2 g/10mL; TAZOBACTAM SODIUM .25 g/10mL | Injection, Powder, For Solution · Intravenous | Apotex Corp. | 60505-6156-04 |
Therapeutic equivalents & pricing 17 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Zosyn in Galaxy Containers 250 mg/50mL; 2 g/50mL | Wyeth | 50 ml | — | — | Discontinued |
| Piperacillin and Tazobactam and Sodium Chloride 250 mg/50mL; 2 g/50mL | B. | 50 ml | — | — | FDA listed |
| Zosyn 2 g/50mL; .25 g/50mL | Baxter | 50 ml | — | — | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Hospira, | 10 vials | — | AP | Discontinued |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Sandoz | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Sandoz | 10 vials | — | AP | Discontinued |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Shandong | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/1; .25 g | WG | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/1; .25 g | Eugia | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Apotex | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Fresenius | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Fresenius | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Fresenius | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | BluePoint | 10 vials | — | AP | FDA listed |
| Piperacillin And Tazobactam 2 g/10mL; .25 g/10mL | Provepharm | 10 vials | — | AP | FDA listed |
| piperacillin and tazobactam 2 g/10mL; .25 g/10mL | ONESOURCE | 10 vials | — | AP | FDA listed |
| Piperacillin and Tazobactam 2 g/10mL; .25 g/10mL | Avenacy, | 10 vials | — | AP | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Piperacillin And Tazobactam Injection — that fall in the same broad treatment class (penicillin antibiotics) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other anti-infective shortages
Piperacillin And Tazobactam Injection shortage FAQs
Is Piperacillin And Tazobactam Injection in shortage?
Which products are affected?
When will Piperacillin And Tazobactam Injection be available again?
Can I still get Piperacillin And Tazobactam somewhere?
What should I do if I take Piperacillin And Tazobactam Injection?
Still have a question about the Piperacillin And Tazobactam Injection shortage?
Ask a pharmacist about this shortage →View Piperacillin And Tazobactam Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.