Sodium Oxybate Solution shortage
Sodium Oxybate Solution is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Oct 2, 2026.
Amneal Pharmaceuticals is stopping its sodium oxybate solution, and the change may be permanent. The same medicine is still listed by other makers, including Xyrem (sodium oxybate) solution from Jazz Pharmaceuticals.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Sodium Oxybate Solution. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Dec 29, 2025Currently in shortage1 of 1 product affected.
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Dec 29, 2025First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Amneal Pharmaceuticals 📞 800-525-7270 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Sodium Oxybate, Solution, .5 g/1 mL (NDC 69238-2391-1) | — | — | Discontinuation of the manufacture of the drug | — |
These rows are manufacturer reports to the FDA for Sodium Oxybate Solution — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Sodium Oxybate Solution? options further down this page.
Why is Sodium Oxybate Solution in shortage?
Amneal Pharmaceuticals has reported to the FDA that they are permanently stopping the manufacture of their sodium oxybate oral solution, 0.5 g/1 mL (the liquid concentration). No specific reason for this decision was shared publicly — the FDA report simply notes it as a discontinuation of manufacturing.
It's worth knowing that this report only covers Amneal's specific product. It does not mean sodium oxybate solution is going away from every manufacturer — other companies that make this medication are listed separately and are not part of this particular report.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Sodium Oxybate Solution, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Sodium Oxybate Solution?
Sodium oxybate oral solution is currently on the FDA shortage list, and I want to walk you through what that means for you.
The strength involved is the 0.5 g/mL solution. Right now, this strength has no available source from the manufacturer that filed this report (Amneal Pharmaceuticals). Because no other strength of this product is on the record, there isn't a separate strength still in supply to point you toward here.
The reason listed is that the maker is discontinuing manufacture of this product. That means this particular supply problem may be permanent rather than temporary. Importantly, this report reflects only one manufacturer — other companies may still make the same medicine, so this does not mean sodium oxybate is gone everywhere.
Here is what I suggest, in order:
- Do not stop, skip, or change your dose on your own.
- Because Amneal's product is being discontinued, ask your prescriber or pharmacist about next steps soon, rather than waiting.
- The same medicine (sodium oxybate solution, 0.5 g/mL) may be available from other makers — Hikma, Camber, or as Xyrem from Jazz. Your pharmacy can try to source one, though it may not be on the local shelf.
- Manufacturer contact numbers are listed on this page for reference; pharmacies usually make these calls.
This is general, national information and may not match your pharmacy's actual stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
- This is a controlled substance. Transfers between pharmacies and switching strengths have extra federal/state rules — ask the pharmacy before you assume a transfer is possible.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Sodium Oxybate Solution?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Sodium Oxybate Solution is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Sodium Oxybate | SODIUM OXYBATE .5 g/mL | Solution · Oral | Hikma Pharmaceuticals USA Inc. | 00054-9628-57 |
| Sodium Oxybate | SODIUM OXYBATE .5 g/mL | Solution · Oral | Camber Pharmaceuticals, Inc. | 31722-0891-18 |
| Sodium Oxybate | SODIUM OXYBATE 500 mg/mL | Solution · Oral | Amneal Pharmaceuticals LLC | 65162-0065-87 |
| Xyrem | SODIUM OXYBATE .5 g/mL | Solution · Oral | Jazz Pharmaceuticals, Inc. | 68727-0100-01 |
Alternative dosage forms of Sodium Oxybate
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 6 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| sodium oxybate .5 g/mL | Hikma | 180 ml | — | AA | FDA listed |
| sodium oxybate .5 g/mL | Camber | 1 bottle | — | AA | FDA listed |
| Sodium Oxybate 500 mg/mL | Amneal | 1 bottle | — | AA | FDA listed |
| Xyrem .5 g/mL | Jazz | 180 ml | — | AA | FDA listed |
| sodium oxybate .5 g/mL | XLCare | 1 bottle | — | AA | FDA listed |
| sodium oxybate 0.5 g/mL | Amneal | 180 ml | — | AA | Discontinued |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Sodium Oxybate Solution — that fall in the same broad treatment class (anti-narcolepsy,anti-cataplexy,sedative-type agent) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other psychiatry shortages
Sodium Oxybate Solution shortage FAQs
Is Sodium Oxybate Solution in shortage?
Which products are affected?
When will Sodium Oxybate Solution be available again?
Can I still get Sodium Oxybate somewhere?
What should I do if I take Sodium Oxybate Solution?
Still have a question about the Sodium Oxybate Solution shortage?
Ask a pharmacist about this shortage →View Sodium Oxybate Solution on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.