Can You Take Sudafed With Amoxicillin?

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Sudafed (pseudoephedrine) and amoxicillin.


Can you take amoxicillin with Sudafed (pseudoephedrine)? I am treating a sinus infection and want to make sure the combination is safe.

Asked by Donnie On Sep 09, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Sep 09, 2022
Last updated Jun 03, 2023

Key points

  • There is no known drug interaction between Sudafed and amoxicillin. They are considered safe to take together.


Sudafed (pseudoephedrine) is safe to take with amoxicillin and there is no interaction between the two medications.

Using both Sudafed and amoxicillin at the same time is fairly common as Sudafed can often help alleviate the symptoms of sinusitis (e.g. congestion & sinus pressure), a common infection treated by amoxicillin. 

Sudafed PE (phenylephrine), the non-pseudoephedrine version of Sudafed, is also safe to take with amoxicillin.

Below, we provide additional information regarding Sudafed and amoxicillin.

Sudafed (Pseudoephedrine)

Sudafed (pseudoephedrine) is a 'sympathomimetic' medication, chemically similar to ephedrine. Sudafed is an effective nasal and sinus decongestant. It can also help to relieve sinus pressure.

Oral decongestants, such as Sudafed, are generally recommended over topical decongestants such as Afrin as oral decongestants are not typically associated with rebound congestion. While Sudafed is generally well tolerated, there is some concern with its use in those with hypertension (i.e. high blood pressure).

Most studies indicate that the use of Sudafed in those with high blood pressure, at recommended doses, does not appear to cause significant increases in blood pressure. Nevertheless, if you do have issues with blood pressure, you should speak with your doctor before using Sudafed. Aside from increases in blood pressure, Sudafed may also cause:

  • Restlessness
  • Headache
  • Lightheadedness
  • Dizziness
  • Insomnia


Amoxicillin is an aminopenicillin antibiotic, structurally similar to penicillin. However, it has a broader spectrum of action (i.e. effective for more types of infection) than penicillin and is generally well tolerated when compared to other antibiotics.

Amoxicillin is indicated for the treatment of a variety of infections including:

  • Otitis media (ear infection)
  • Sinusitis
  • Upper respiratory infections
  • Urinary tract infections (UTIs)

Amoxicillin is generally taken for 10 to 14 days and can be given without regard to food in most cases. Outside the potential for allergic reaction, the most common side effects are:

  • Urine odor
  • Diarrhea
  • Headache
  • Nausea

Final Words

As discussed above, Sudafed (pseudoephedrine) is safe to take with amoxicillin and there is no interaction between the two.

About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at! You can also connect with Dr. Brian Staiger on LinkedIn.

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