Can You Take Tylenol With A Zpak (Azithromycin)?
In our latest question and answer, the pharmacist discusses whether or not amoxicillin it is safe to combine Tylenol with a Zpak

Question
I have just been prescribed something called a Zpak for bronchitis. Can I take Tylenol with it?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 20, 2025
Key points
- There is no drug interaction between Tylenol and a Zpak. They are safe to take together.
Answer
Hi there and thanks for reaching out!
Yes, Tylenol (acetaminophen) can be combined with a Zpak (azithromycin). There is no interaction between them and they are safe to take together.
It's not uncommon at all that a pain reliever like Tylenol is combined with antibiotics, especially when you are treating something like bronchitis, which generally causes a sore throat. There is no need to separate dosing of either from each other. They can even be taken at the same time.
Other pain relievers are safe to take with azithromycin as well, including ibuprofen. However, ibuprofen does have more interactions with other drugs and has more precautions, so more often than not, Tylenol is the over-the-counter pain reliever of choice.
Thanks again for your question and feel free to reach out again in the future.
About Acetaminophen
Acetaminophen is used to relieve mild to moderate pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. It may also be used to relieve the pain of osteoarthritis (arthritis caused by the breakdown of the lining of the joints).
Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
About Azithromycin
Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. It also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)].
Azithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria.
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Dr. Brian Staiger, PharmD
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