Can You Take Zyrtec And Singulair Together?

Answer

Yes, Zyrtec (cetirizine) and Singulair (montelukast) can safely be taken together. There is no drug interaction between them.

Both drugs work via different mechanisms and do not interfere with one another. In fact, several studies show that combining an antihistamine, like Zyrtec, and a leukotriene receptor antagonist (LTRA), like Singulair, can be more effective in treating allergy symptoms than either drug alone (although data is mixed in this regard).

What Do Studies Show?

As mentioned, you may get the most relief of your allergy symptoms if you combine drugs like Zyrtec and Singular.

One study, which evaluated the combination of antihistamines and leukotriene antagonists, concluded the following:

The current evidence suggests that LTRAs [leukotriene receptor antagonists such as Singulair) + H1 [histamine-1 blockers, like Zyrtec] can increase the therapeutic efficacy against daytime and composite nasal symptoms, including rhinorrhea, sneezing, and itching...

Other studies have found somewhat conflicting results, but there is no interaction between the drugs, and they, at the very least, won't alter how the other works.

Zyrtec And Singular Work In Different Ways

Zyrtec and Singulair work via different pathways to help treat allergy symptoms.

Zyrtec is a second-generation antihistamine, which blocks the H1 (histamine-1) receptor, preventing histamine from binding to it (which prevents the histamine-induced inflammatory response).

Singulair blocks the leukotriene D4 (LTD4) receptor. This, in turn, blocks the action of several different substances in the body that cause allergy symptoms.

Although Zyrtec and Singulair prevent the release of similar substances (e.g., mast cells, eosinophils), they do so differently.

Final Words

I hope you found this helpful!

I also hope you find your new therapy of Zyrtec and Singulair effective. I know how challenging it can be to find effective therapies to treat allergies.

Thanks for reaching out!