Is It Safe to Take a Beetroot Supplement With Eliquis?
Beetroot supplements are popular for blood pressure and exercise support, and this question looks at whether they can be safely combined with the anticoagulant Eliquis (apixaban).
Is it safe to take a beetroot supplement with Eliquis?
Jul 28, 2026- Beetroot doesn't have a documented interaction with Eliquis and is considered low-risk for most people, though the combination hasn't been formally studied. Beetroot is unlikely to affect how your body processes Eliquis since it doesn't meaningfully inhibit or induce the liver enzymes and transporters responsible for clearing the medication. While laboratory research suggests beetroot may have a mild effect on platelets, there are no published reports of bleeding problems when combining it with apixaban. Let your doctor or pharmacist know you're taking a beetroot supplement, especially if you also take blood pressure medication, and watch for any unusual bruising or bleeding.
Hello, and I'm glad you brought this question to us!
Beetroot doesn't have a well-documented interaction with Eliquis (apixaban), and for most people it's considered a low-risk supplement to add. That said, the combination hasn't been formally studied, and there are a couple of points worth understanding that I discuss below.
How Eliquis Interactions Usually Happen
Eliquis interactions tend to come from two directions. The first is anything that changes how the drug is processed in the body.
Eliquis is cleared by the liver enzyme CYP3A4 and moved around by a transporter protein called P-glycoprotein (P-gp), so substances that strongly block those pathways can raise apixaban levels and increase bleeding risk, while substances that rev them up (St. John's wort is the classic herbal example) can lower apixaban levels and leave you less protected against clots.
The second direction is anything with its own blood-thinning or antiplatelet activity, since stacking that on top of an anticoagulant adds to the chance of bleeding.
Where Beetroot Fits in With Eliquis
Beetroot is best known for being naturally rich in dietary nitrates, which the body converts to nitric oxide, and that's the main reason it's marketed for blood pressure support and athletic performance.
Beetroot isn't known to meaningfully inhibit or induce CYP3A4 or P-gp, so it isn't expected to change the amount of Eliquis in your body.
On the clotting side, there is some laboratory research suggesting nitrate-rich beetroot may have a mild effect on platelet activity, but this hasn't been well characterized in humans and there are no published reports of bleeding problems from combining beetroot with apixaban.
In other words, an interaction isn't expected, but the honest answer is that the pair simply hasn't been studied directly, which is why running it by your pharmacist or doctor is still the smart move.
Final Words
Overall, beetroot is not known to interact with Eliquis and is generally considered a safe addition for most people, though the combination hasn't been formally studied.
Let your doctor or pharmacist know you're planning to take it, especially if you also take blood pressure medication, and keep an eye out for any unusual bruising or bleeding. I hope this helps!
References & sources
Dr. Brian Staiger, PharmD
Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified
Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...
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