Apixaban
289 interactions 221 explained in plain English 535 cited references
Also sold as:
Eliquis
Eliquis®
About Apixaban
Apixaban is a blood clot preventative medication that blocks clot formation and treats conditions like atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Read the full Apixaban drug information page →
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 12, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Defibrotide
Defibrotide Injection
Ensitrelvir
Abametapir
Oxaliplatin Injection
Ticlopidine
Contraindicated
Apixaban Defibrotide Explained Increased risk of bleeding Details Apixaban Ensitrelvir Explained Increased CYP3A/P-gp substrate exposure and an increased risk of adverse reactions Details Apixaban Defibrotide Injection Defitelio Increased risk of bleeding DetailsMajor
Apixaban Abametapir Explained Increased exposure of CYP3A4 substrate Details Apixaban Sertraline Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Abciximab Explained An increased risk of bleeding Details Apixaban Abiraterone Acetate Abirtega Explained Increased apixaban exposure Details Apixaban Abiraterone Acetate, Micronized Abirtega Explained Increased apixaban exposure Details Apixaban Aceclofenac Explained An increased risk of bleeding Details Apixaban Acemetacin Explained An increased risk of bleeding Details Apixaban Acenocoumarol Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Adagrasib Krazati Explained Increased apixaban exposure and an increased risk of bleeding Details Apixaban Alipogene Tiparvovec Explained An increased risk of bleeding Details Apixaban Alteplase, Recombinant Activase Explained An increased risk of bleeding Details Apixaban Amtolmetin Guacil Explained An increased risk of bleeding Details Apixaban Anagrelide Agrylin Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Anistreplase Explained An increased risk of bleeding Details Apixaban Apalutamide Erleada Explained Reduced apixaban exposure, reduced efficacy of apixaban and an increased risk of stroke and other thromboembolic events Details Apixaban Ardeparin Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Argatroban Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Aspirin Acuprin® Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Atazanavir Reyataz Explained Increased apixaban exposure and an increased risk of bleeding Details Apixaban Avacopan Tavneos Explained Increased CYP3A4 substrate exposure Details Apixaban Bemiparin Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Berotralstat Orladeyo Explained Increased P-gp substrate exposure Details Apixaban Betrixaban Bevyxxa® Explained Increased risk of bleeding Details Apixaban Bivalirudin Angiomax Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Boceprevir Explained Increased apixaban exposure and an increased risk of bleeding Details Apixaban Bromfenac Bromsite Explained An increased risk of bleeding Details Apixaban Bufexamac Explained An increased risk of bleeding Details Apixaban Cangrelor Kengreal Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Caplacizumab-Yhdp Explained An increased risk of bleeding Details Apixaban Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Apixaban Carbamazepine Carbatrol Explained Reduced apixaban exposure, reduced efficacy of apixaban and an increased risk of stroke and other thromboembolic events Details Apixaban Celecoxib Celebrex Explained An increased risk of bleeding Details Apixaban Ceritinib Zykadia Explained Increased CYP3A substrate exposure Details Apixaban Certoparin Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Choline Salicylate Explained An increased risk of bleeding Details Apixaban Cilostazol Pletal® Explained Increased risk of bleeding and can cause serious, potentially fatal bleeding Details Apixaban Citalopram Celexa Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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