Drug & supplement interaction

Palm Oil + Apixaban

Apixaban brand name: Eliquis.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Palm Oil has a moderate interaction with Apixaban. Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Palm Oil and Apixaban

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Apixaban

Apixaban falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Palm Oil interacts with.

Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
The palm olein constituent in palm oil seems to increase platelet aggregation.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Eliquis (apixaban): this medicine is a blood thinner that helps keep dangerous clots from forming. The concern with palm oil is that one of its components, called palm olein, may make your platelets a little stickier and more likely to clump. In theory, that could nudge against what your apixaban is trying to do and slightly weaken your clot protection.

I want to be honest about how soft this evidence is. It's largely theoretical, and the everyday amount of palm oil you'd get cooking or in foods is very unlikely to throw off your apixaban. Concentrated palm oil supplements are the bigger question mark. Before starting any, check with your pharmacist or doctor, and don't change your apixaban on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Sanchez-Muniz FJ, Oubina P, Rodenas S, et al. Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein. Eur J Nutr 2003:42:299-306. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Palm Oil Also Interacts With Other Medications

Palm Oil has 121 moderate known drug interactions in our database — the Apixaban one above is one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Apixaban)
Taking anything else?

Check Another of Your Medications Against Palm Oil

Covers the 2,830 medications we’ve checked against Palm Oil. Pick one to open its full report.

From our Q&A

Questions About Palm Oil or Apixaban

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Palm Oil or Apixaban, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Apixaban

This page covers Palm Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Apixaban page lists 285 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Grapefruit (major), Piracetam (major) and St. John's Wort (major).

By severity: 5 major · 240 moderate · 40 minor.

From our pharmacist’s overview on the Apixaban page

“St. John's wort can weaken apixaban (Eliquis), speeding how the body clears this blood thinner and leaving you less protected from the strokes and clots it is prescribed to prevent.”

Reviewed by 2 · Jul 18, 2026

Open the Apixaban interaction page

One more smart check

Taking Palm Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 55 real supplement products containing Palm Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Palm Oil. Your product may carry other ingredients that interact with Apixaban too, on top of Palm Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Palm Oil and Apixaban Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Palm Oil
Top half

#419 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Apixaban
Most looked up

#1 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Palm Oil

What is Palm Oil?

  • Cooking and food preparation
  • Source of vitamin A (red palm oil)
  • Vitamin E (tocotrienols)
  • Skin and hair care
  • General nutrition

Palm oil is a widely used edible oil pressed from the fruit of the oil palm tree, and red palm oil is a notable source of vitamin A and vitamin E compounds called tocotrienols. As a food it is generally considered safe, but it is high in saturated fat, so it should be used in moderation as part of a balanced diet. Talk with your pharmacist or doctor before using concentrated palm-oil supplements, especially if you have heart or cholesterol concerns.

Read the full Palm Oil monograph & all interactions
Medication

About Apixaban

What Is Apixaban Used For?

Brand name: Eliquis

Apixaban is used to reduce the risk of stroke and dangerous clots traveling through the body in adults with nonvalvular atrial fibrillation (an irregular heart rhythm not caused by a heart valve problem). It is also used to prevent deep vein thrombosis (DVT — a blood clot in the leg) in adults after hip or knee replacement surgery, and to treat DVT and pulmonary embolism (PE — a blood clot in the lungs) in adults, including reducing the risk of those clots coming back.

Eliquis (the brand-name tablet and kit) is additionally approved to treat venous thromboembolism (VTE — blood clots in the veins) and reduce the risk of recurrent VTE in pediatric patients from birth and older, after at least 5 days of initial anticoagulant treatment. The generic apixaban tablet carries the adult indications only.

See full Apixaban drug information
Keep checking

Other Drugs & Palm Oil

Browse every other medication we’ve checked against Palm Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Palm Oil page.

No interaction 2,708 drugs checked — show the list

We also checked Palm Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Palm Oil list.

See the full Palm Oil interactions page
See every supplement checked against Apixaban, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Palm Oil monograph › Uses, safety, and every drug interaction in one place Apixaban supplement interactions › Every supplement checked against Apixaban, ranked by severity Apixaban drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Palm Oil and Apixaban Together: Common Questions

Can you take Palm Oil with Apixaban?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Palm Oil and Apixaban interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Apixaban and Palm Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.