Apixaban and Feprazone: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Aug 8, 2026 · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Apixaban
Feprazone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Taking these two together can raise your chance of bleeding. Apixaban (Eliquis) is a blood thinner, and feprazone is an anti-inflammatory (NSAID) medicine. Each one can make bleeding more likely on its own. When you take them together, those effects add up, so you may bruise more easily or bleed more than usual.
Watch for warning signs like unusual bruising, blood in your urine or stool, black stools, nosebleeds that won't stop, or coughing up blood. Please don't stop either medicine on your own. Your doctor or pharmacist can help you use them safely and will keep an eye on you if you need both.
Additive bleeding risk (PD interaction). Apixaban is a direct factor Xa inhibitor; feprazone is an NSAID that impairs platelet function and can cause GI mucosal injury. Neither is a prodrug here; the interaction is pharmacodynamic, not metabolic.
- Direction: additive impairment of hemostasis, increased bleeding risk versus either alone.
- Evidence: theoretical; severity rated major.
- Key risk: spinal/epidural hematoma with neuraxial anesthesia or spinal puncture.
- Management: monitor for signs/symptoms of bleeding (CBC/hemoglobin, stool, bruising); consider gastroprotection or an alternative analgesic; dosing should be individualized by the care team.
What happens
An increased risk of bleeding
Interaction Deep Dive
Taking an anticoagulant together with an NSAID can raise the likelihood of serious bleeding compared with either agent used by itself1234, and in patients receiving neuraxial anesthesia or undergoing spinal puncture, this combination can heighten the chance of epidural or spinal hematomas, which may lead to prolonged or permanent paralysis5. When the two are given together, watch for indications of bleeding124.
Why it happens (mechanism)
Additive effect on hemostasis
How to manage this interaction
This combination can usually be managed with care and monitoring. Keep taking both exactly as prescribed unless your care team tells you otherwise.
- Your team may watch you more closely for signs of bleeding, and any dosing may need to be adjusted and individualized by them.
- Tell your pharmacist and prescriber that you take both, especially before any surgery, spinal injection, or spinal tap.
- Report right away: unusual bruising, black or bloody stools, pink or red urine, prolonged nosebleeds, or coughing up blood.
- Ask whether a different pain reliever might be a safer option for you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Apixaban and Feprazone together?
Combining apixaban (Eliquis) with the NSAID feprazone adds up their bleeding risk, so watch closely for bleeding and let your care team guide whether both are right for you. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Apixaban and Feprazone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Apixaban and Feprazone interaction managed?
This combination can usually be managed with care and monitoring. Keep taking both exactly as prescribed unless your care team tells you otherwise. Your team may watch you more closely for signs of bleeding, and any dosing may need to be adjusted and individualized by them. Tell your pharmacist and prescriber that you take both, especially before any surgery, spinal injection, or spinal tap. Repor… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Apixaban or Feprazone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (5)
- Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016. DailyMed
- Product Information: CELEBREX(R) oral capsules, celecoxib oral capsules. GD Searle LLC (per FDA), New York, NY, 2016. DailyMed
- Product Information: COUMADIN(R) oral tablets, intravenous injection powder for solution, warfarin sodium oral tablets, intravenous injection powder for solution. Bristol-Myers Squibb Company (per manufacturer), Princeton, NJ, 2015. DailyMed
- Product Information: COMBOGESIC(R) oral tablets, acetaminophen ibuprofen oral tablets. AFT Pharmaceuticals Inc (per FDA), Highland, MD, 2023. DailyMed
- Product Information: PRADAXA(R) oral capsules, dabigatran etexilate oral capsules. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2023. DailyMed
Keep reading about Apixaban
Keep reading about Feprazone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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