Taking Buspar (Buspirone) Once A Day Versus Multiple Times Per Day
In our latest question and answer, the pharmacist discusses dosing recommendations for the anti-anxiety medication Buspar (buspirone).

Question
I am taking 10mg of Buspar in the AM, as well as 20mg of Busbar and 10mg of Paxil in the PM. Can I take all these meds in the AM instead of splitting them up?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated May 08, 2025
Key points
- Buspar (buspirone) is typically dosed 2 to 3 times daily.
- Taking a larger dose of Buspar at once won't make the drug last longer. Each doses generally lasts 4 to 8 hours.
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You should not combine your morning and evening doses of Buspar (buspirone). Buspar is indicated to be dosed two to three times a day and taking the entire dose at once in the morning will likely result in effects of the drug not lasting all day. It could also increase the risk of dose-dependent side effects, such as:
- Dizziness
- Drowsiness
- Nervousness
- Lightheadedness
- Excitability
- Anger/hostility
- Confusion
- Numbness
- Headache
- Incoordination
Buspar Dosing
Per the prescribing information for Buspar, it is indicated to be dosed as follows:
- Starting dose of 7.5 mg by mouth twice daily, then increase as needed by 5 mg/day every 2 to 3 days. The usual maintenance dose is 15 to 30 mg/day administered in 2 to 3 divided doses
Effects of Buspar generally last 4-8 hours, but this can vary by individual. Increasing your dose in the morning will most likely not make it last longer, which is why the drug is recommended to take in divided doses throughout the day. Even if you take a larger dose at once, that won't make the drug last any longer.
Final Words
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Dr. Brian Staiger, PharmD
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