Abemaciclib

Name: Abemaciclib Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

128 interactions 114 explained in plain English 328 cited references

Also sold as: Verzenio Verzenio®

About Abemaciclib

Abemaciclib is used in combination with an aromatase inhibitor such as anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) to treat a certain type of hormone receptor-positive, early breast cancer. Abemaciclib is also used along with fulvestrant (Faslodex) to treat a certain type of hormone receptor-po… Read the full Abemaciclib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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12 Contraindicated 75 Major 41 Moderate

All (128) Contraindicated (12) Major (75) Moderate (41)

Moderate

Abemaciclib Telaprevir Explained Increased abemaciclib plasma concentration Details Abemaciclib Telithromycin Explained Increased abemaciclib plasma concentration Details Abemaciclib Verapamil Calan Explained Increased abemaciclib plasma concentration Details Abemaciclib Voriconazole Vfend Explained Increased abemaciclib plasma concentration Details Abemaciclib Xanomeline Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Abemaciclib Cyclosporine Injection Atopica Increased abemaciclib plasma concentration Details Abemaciclib Cyclosporine Ophthalmic Cequa Increased abemaciclib plasma concentration Details Abemaciclib Letermovir Injection Prevymis Increased abemaciclib plasma concentration Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.