Abemaciclib

128 interactions 114 explained in plain English 328 cited references

Also sold as: Verzenio Verzenio®

About Abemaciclib

Abemaciclib is used in combination with an aromatase inhibitor such as anastrozole (Arimidex), exemestane (Aromasin), or letrozole (Femara) to treat a certain type of hormone receptor-positive, early breast cancer. Abemaciclib is also used along with fulvestrant (Faslodex) to treat a certain type of hormone receptor-po… Read the full Abemaciclib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

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12 Contraindicated 75 Major 41 Moderate

All (128) Contraindicated (12) Major (75) Moderate (41)

Moderate

Abemaciclib Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Abemaciclib Aprepitant Aponvie Explained Increased abemaciclib plasma concentration Details Abemaciclib Artemether Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Abemaciclib Atazanavir Reyataz Explained Increased abemaciclib plasma concentration Details Abemaciclib Boceprevir Explained Increased abemaciclib plasma concentration Details Abemaciclib Ciprofloxacin Explained Increased abemaciclib plasma concentration Details Abemaciclib Clarithromycin Biaxin Explained Increased abemaciclib plasma concentration Details Abemaciclib Cobicistat Tybost Explained Increased abemaciclib plasma concentration Details Abemaciclib Conivaptan Vaprisol Explained Increased abemaciclib plasma concentration Details Abemaciclib Crizotinib Xalkori Explained Increased abemaciclib plasma concentration Details Abemaciclib Cyclosporine Atopica Explained Increased abemaciclib plasma concentration Details Abemaciclib Diltiazem Cardizem Explained Increased abemaciclib plasma concentration Details Abemaciclib Dronedarone Multaq Explained Increased abemaciclib plasma concentration Details Abemaciclib Erythromycin Erythrocin Stearate Explained Increased abemaciclib plasma concentration Details Abemaciclib Fluconazole Diflucan Explained Increased abemaciclib plasma concentration Details Abemaciclib Fluvoxamine Explained Increased abemaciclib plasma concentration Details Abemaciclib Fosnetupitant Explained Increased abemaciclib plasma concentration Details Abemaciclib Idelalisib Zydelig Explained Increased abemaciclib plasma concentration Details Abemaciclib Imatinib Gleevec Explained Increased abemaciclib plasma concentration Details Abemaciclib Indinavir Explained Increased abemaciclib plasma concentration Details Abemaciclib Itraconazole Sporanox Explained Increased abemaciclib plasma concentration Details Abemaciclib Kratom Explained Increased CYP3A substrate exposure Details Abemaciclib Letermovir Prevymis Explained Increased abemaciclib plasma concentration Details Abemaciclib Lopinavir Explained Increased abemaciclib plasma concentration Details Abemaciclib Mavacamten Camzyos Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Abemaciclib Nefazodone Explained Increased abemaciclib plasma concentration Details Abemaciclib Nelfinavir Viracept Explained Increased abemaciclib plasma concentration Details Abemaciclib Netupitant Explained Increased abemaciclib plasma concentration Details Abemaciclib Nilotinib Explained Increased abemaciclib plasma concentration Details Abemaciclib Posaconazole Noxafil Explained Increased abemaciclib plasma concentration Details Abemaciclib Rilzabrutinib Wayrilz Explained Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Abemaciclib Ritonavir Norvir Explained Increased abemaciclib plasma concentration Details Abemaciclib Saquinavir Explained Increased abemaciclib plasma concentration Details Abemaciclib Telaprevir Explained Increased abemaciclib plasma concentration Details Abemaciclib Telithromycin Explained Increased abemaciclib plasma concentration Details Abemaciclib Verapamil Calan Explained Increased abemaciclib plasma concentration Details Abemaciclib Voriconazole Vfend Explained Increased abemaciclib plasma concentration Details Abemaciclib Xanomeline Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details Abemaciclib Cyclosporine Injection Atopica Increased abemaciclib plasma concentration Details Abemaciclib Cyclosporine Ophthalmic Cequa Increased abemaciclib plasma concentration Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.