Abiraterone and Dihydrocodeine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dihydrocodeine
No brand names on recordAbiraterone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased dihydrocodeine exposure and reduced exposure of active metabolite
Interaction Deep Dive
Concomitant use of dihydrocodeine and a CYP2D6 inhibitor may reduce plasma concentrations of morphine, the active metabolite of codeine, potentially leading to reduced opioid efficacy and in some patients, signs or symptoms of opioid withdrawal. If coadministration is necessary, monitor for withdrawal symptoms and consider increasing the dihydrocodeine dosage. When discontinuing a concurrent CYP2D6 inhibitor, consider reducing the dihydrocodeine dose and monitor for respiratory depression12.
Why it happens (mechanism)
Inhibition of CYP2D6-mediated dihydrocodeine metabolism
Common questions
Can I take Abiraterone and Dihydrocodeine together?
Increased dihydrocodeine exposure and reduced exposure of active metabolite Always confirm with your pharmacist or prescriber before making any change.
How serious is the Abiraterone and Dihydrocodeine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Abiraterone or Dihydrocodeine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: TREZIX(TM) oral capsules, acetaminophen caffeine dihydrocodeine bitartrate oral capsules. WraSer Pharmaceuticals (per DailyMed), Ridgeland, MS, 2016. DailyMed
- Product Information: SYNALGOS(R)-DC oral capsules, aspirin, caffeine, dihydrocodeine bitartrate oral capsules. Sun Pharmaceuticals Industries Inc (per FDA), Cranbury, NJ, 2023. DailyMed
Keep reading about Dihydrocodeine
Keep reading about Abiraterone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist