Dihydrocodeine
54 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Linezolid Injection
Clopidogrel
Amitriptyline
Furosemide Injection
Palonosetron Injection
Cyclosporine Ophthalmic
Contraindicated
Dihydrocodeine Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity DetailsMajor
Dihydrocodeine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Dihydrocodeine Amitriptyline Elavil Explained Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Dihydrocodeine Sertraline Explained Increased dihydrocodeine exposure, reduced exposure of active metabolite, and increased risk of serotonin syndrome Details Dihydrocodeine Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Dihydrocodeine Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Dihydrocodeine Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Dihydrocodeine Abiraterone Abirtega Increased dihydrocodeine exposure and reduced exposure of active metabolite Details Dihydrocodeine Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Dihydrocodeine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Dihydrocodeine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Dihydrocodeine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Dihydrocodeine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Dihydrocodeine Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Cyclosporine Injection Atopica Increased dihydrocodeine exposure and an increased risk of respiratory depression Details Dihydrocodeine Cyclosporine Ophthalmic Cequa Increased dihydrocodeine exposure and an increased risk of respiratory depression Details Dihydrocodeine Dexamethasone Injection Decadron Reduced dihydrocodeine exposure Details Dihydrocodeine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced dihydrocodeine exposure Details Dihydrocodeine Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Dihydrocodeine Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Dihydrocodeine Diphenhydramine Injection Banophen Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Dihydrocodeine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Dihydrocodeine Dolasetron Anzemet Increased risk of serotonin syndrome Details Dihydrocodeine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Dihydrocodeine Esketamine Nasal Spray Spravato Increased risk of sedation Details Dihydrocodeine Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Dihydrocodeine Flecainide Tambocor® Increased dihydrocodeine exposure and reduced exposure of active metabolite Details Dihydrocodeine Furosemide Injection Disal Reduced efficacy of diuretics Details Dihydrocodeine Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Dihydrocodeine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Dihydrocodeine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Dihydrocodeine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Dihydrocodeine Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Dihydrocodeine Ketoconazole Topical Extina® Foam Increased dihydrocodeine exposure and an increased risk of respiratory depression Details Dihydrocodeine Lacosamide Injection Motpoly An increased risk of CNS depression DetailsNo interactions on this 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