Acetaminophen

Name: Acetaminophen Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

33 interactions 489 cited references

Also sold as: Acephen Actamin® Anacin AF Bactimicina Cetafen Comtrex Sore Throat Relief CounterAct Pain Feverall Feverall® Little Fevers Mapap Nortemp Panadol Panadol® Pharbetol Redutemp Ringl Tactinal Tempra Quicklets Tempra Quicklets® Tycolene Tylenol Tylenol Gelcap Extra Strength Tylenol®

About Acetaminophen

Acetaminophen is a pain reliever and fever reducer used to treat mild to moderate pain and reduce fever. Read the full Acetaminophen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Carbamazepine Exenatide Flucloxacillin Imatinib Isoniazid

11 Major 15 Moderate 7 Minor

All (33) Major (11) Moderate (15) Minor (7)

Minor

Acetaminophen Chloramphenicol Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Cholestyramine Prevalite Decreased acetaminophen effectiveness Details Acetaminophen Fenoldopam Increased fenoldopam concentration Details Acetaminophen Lamotrigine Lamictal Decreased lamotrigine effectiveness Details Acetaminophen Metyrapone Metopirone An increased risk of acetaminophen toxicity Details Acetaminophen Chloramphenicol Injection Chloromycetin® Injection Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Cholestyramine Resin Locholest® Decreased acetaminophen effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.