Acetaminophen

33 interactions 489 cited references
Also sold as: Acephen Actamin® Anacin AF Bactimicina Cetafen Comtrex Sore Throat Relief CounterAct Pain Feverall Feverall® Little Fevers Mapap Nortemp Panadol Panadol® Pharbetol Redutemp Ringl Tactinal Tempra Quicklets Tempra Quicklets® Tycolene Tylenol Tylenol Gelcap Extra Strength Tylenol®
About Acetaminophen

Acetaminophen is a pain reliever and fever reducer used to treat mild to moderate pain and reduce fever. Read the full Acetaminophen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Carbamazepine Exenatide Flucloxacillin Imatinib Isoniazid
11 Major 15 Moderate 7 Minor
All (33) Major (11) Moderate (15) Minor (7)

Major

Acetaminophen Articaine An increased risk of methemoglobinemia Details Acetaminophen Carbamazepine Carbatrol An increased risk of acetaminophen hepatotoxicity and reduced acetaminophen exposure Details Acetaminophen Exenatide Bydureon Reduced oral acetaminophen absorption and reduced efficacy of oral acetaminophen Details Acetaminophen Flucloxacillin An increased risk of high anion gap metabolic acidosis (HAGMA) Details Acetaminophen Imatinib Gleevec Increased acetaminophen levels Details Acetaminophen Isoniazid An increased risk of hepatotoxicity Details Acetaminophen Lidocaine Akten An increased risk of methemoglobinemia Details Acetaminophen Pixantrone Increased CYP1A2 substrate exposure Details Acetaminophen Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate An inadequate immunologic response to the vaccine Details Acetaminophen Probenecid Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details Acetaminophen Exenatide Injection Bydureon Reduced oral acetaminophen absorption and reduced efficacy of oral acetaminophen Details

Moderate

Acetaminophen Acenocoumarol Potentiation of anticoagulant effect Details Acetaminophen Busulfan Busulfex Reduced busulfan clearance Details Acetaminophen Diflunisal Dolobid An increased risk of acetaminophen toxicity (hepatotoxicity) Details Acetaminophen Ethinyl Estradiol Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Fosphenytoin Cerebyx Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen Lixisenatide Slowed absorption of acetaminophen Details Acetaminophen Norethindrone Aygestin Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Norgestimate Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Phenytoin Dilantin Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen Piperaquine Reduced exposure of CYP2E1 substrates Details Acetaminophen Sulfinpyrazone Increased hepatotoxicity in acetaminophen overdose Details Acetaminophen Warfarin Coumadin An increased risk of bleeding Details Acetaminophen Zidovudine Retrovir Neutropenia; acetaminophen toxicity (hepatotoxicity) Details Acetaminophen Busulfan Injection Busulfex Reduced busulfan clearance Details Acetaminophen Lixisenatide Injection Adlyxin® Slowed absorption of acetaminophen Details

Minor

Acetaminophen Chloramphenicol Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Cholestyramine Prevalite Decreased acetaminophen effectiveness Details Acetaminophen Fenoldopam Increased fenoldopam concentration Details Acetaminophen Lamotrigine Lamictal Decreased lamotrigine effectiveness Details Acetaminophen Metyrapone Metopirone An increased risk of acetaminophen toxicity Details Acetaminophen Chloramphenicol Injection Chloromycetin® Injection Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Cholestyramine Resin Locholest® Decreased acetaminophen effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.