Acyclovir Injection

Name: Acyclovir Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 535 cited references

Also sold as: Avaclyr Sitavig Zovirax Zovirax® Injection®

About Acyclovir Injection

Acyclovir injection is used to treat first-time or repeat outbreaks of herpes simplex (a herpes virus infection of the skin and mucus membranes) and to treat herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past) in people with weak immune systems. It is also used to treat first-t… Read the full Acyclovir Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bupropion Clomipramine Dichlorphenamide Emtricitabine Fexinidazole

1 Contraindicated 17 Major 5 Moderate 1 Minor

All (24) Contraindicated (1) Major (17) Moderate (5) Minor (1)

Contraindicated

Acyclovir Injection Fezolinetant Increased fezolinetant exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.