Acyclovir Injection

Name: Acyclovir Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 535 cited references

Also sold as: Avaclyr Sitavig Zovirax Zovirax® Injection®

About Acyclovir Injection

Acyclovir injection is used to treat first-time or repeat outbreaks of herpes simplex (a herpes virus infection of the skin and mucus membranes) and to treat herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past) in people with weak immune systems. It is also used to treat first-t… Read the full Acyclovir Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bupropion Clomipramine Dichlorphenamide Emtricitabine Fexinidazole

1 Contraindicated 17 Major 5 Moderate 1 Minor

All (24) Contraindicated (1) Major (17) Moderate (5) Minor (1)

Moderate

Acyclovir Injection Fosphenytoin Cerebyx Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Injection Meperidine Demerol Increased meperidine and its metabolite normeperidine exposure Details Acyclovir Injection Phenytoin Dilantin Decreased phenytoin plasma concentrations and potential increased seizure activity Details Acyclovir Injection Probenecid Increased OAT3 substrate exposure Details Acyclovir Injection Valproic Acid Depakene® Decreased valproic acid plasma concentrations and potential increased seizure activity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.