Acyclovir Injection

24 interactions 535 cited references
Also sold as: Avaclyr Sitavig Zovirax Zovirax® Injection®
About Acyclovir Injection

Acyclovir injection is used to treat first-time or repeat outbreaks of herpes simplex (a herpes virus infection of the skin and mucus membranes) and to treat herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past) in people with weak immune systems. It is also used to treat first-t… Read the full Acyclovir Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fezolinetant Bupropion Clomipramine Dichlorphenamide Emtricitabine Fexinidazole
1 Contraindicated 17 Major 5 Moderate 1 Minor
All (24) Contraindicated (1) Major (17) Moderate (5) Minor (1)

Major

Acyclovir Injection Bupropion Aplenzin Increased risk of seizures Details Acyclovir Injection Clomipramine Anafranil Increased clomiPRAMINE exposure and an increased risk of seizures Details Acyclovir Injection Dichlorphenamide Increased OAT1 substrate exposure Details Acyclovir Injection Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Acyclovir Injection Fexinidazole Increased exposure of OAT1/OAT3 substrate Details Acyclovir Injection Foscarnet Foscavir Nephrotoxicity Details Acyclovir Injection Hydroxychloroquine Plaquenil An increased risk of seizures Details Acyclovir Injection Leflunomide Arava Increased exposure of OAT3 substrate Details Acyclovir Injection Mycophenolate Mofetil Increased acyclovir exposure and an increased risk of acyclovir-related adverse reactions Details Acyclovir Injection Nitisinone Increased OAT1 or OAT3 substrate exposure and an increased risk of OAT1 or OAT3 substrate-related adverse effects Details Acyclovir Injection Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Acyclovir Injection Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Acyclovir Injection Teriflunomide Aubagio Increased exposure of OAT3 substrate Details Acyclovir Injection Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Acyclovir Injection Tramadol ConZip An increased risk of seizure Details Acyclovir Injection Vadadustat Vafseo Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Acyclovir Injection Warfarin Coumadin Increased warfarin exposure and an increased INR Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.