Acyclovir Ophthalmic

24 interactions 535 cited references
Also sold as: Avaclyr Avaclyr® Sitavig Zovirax
About Acyclovir Ophthalmic

Ophthalmic acyclovir is used to treat an infection of the eye caused by herpes simplex virus. Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the eye. Read the full Acyclovir Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Acyclovir Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Acyclovir Ophthalmic Clomipramine Anafranil Increased clomiPRAMINE exposure and an increased risk of seizures Details Acyclovir Ophthalmic Dichlorphenamide Increased OAT1 substrate exposure Details Acyclovir Ophthalmic Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Acyclovir Ophthalmic Fexinidazole Increased exposure of OAT1/OAT3 substrate Details Acyclovir Ophthalmic Foscarnet Foscavir Nephrotoxicity Details Acyclovir Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures Details Acyclovir Ophthalmic Leflunomide Arava Increased exposure of OAT3 substrate Details Acyclovir Ophthalmic Mycophenolate Mofetil Increased acyclovir exposure and an increased risk of acyclovir-related adverse reactions Details Acyclovir Ophthalmic Nitisinone Increased OAT1 or OAT3 substrate exposure and an increased risk of OAT1 or OAT3 substrate-related adverse effects Details Acyclovir Ophthalmic Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Acyclovir Ophthalmic Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Acyclovir Ophthalmic Teriflunomide Aubagio Increased exposure of OAT3 substrate Details Acyclovir Ophthalmic Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Acyclovir Ophthalmic Tramadol ConZip An increased risk of seizure Details Acyclovir Ophthalmic Vadadustat Vafseo Increased OAT3 substrate exposure and an increased risk of OAT3 substrate-related adverse effect Details Acyclovir Ophthalmic Warfarin Coumadin Increased warfarin exposure and an increased INR Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.